Oncoimmunology. 2014 Dec 13;3(9):e954968. doi: 10.4161/21624011.2014.954968. eCollection 2014 Oct.

New insights into androgenic immune regulation.

Oncoimmunology

Mohamed Simo Arredouani

PMID: 25941609 PMCID: PMC4292726 DOI: 10.4161/21624011.2014.954968

Abstract

Androgens negatively affect both central and peripheral immunity. Their potent immunosuppressive ability is thought to lead to gender dimorphism in autoimmune and infectious disease and hamper immunosurveillance of tumors. Therefore, we investigated the molecular underpinnings of androgens suppression of T-cell differentiation and found evidence that developing strategies to counteract these inhibitory effects may foster successful cancer immunotherapy in the future.

Keywords: PTPN1 phosphatase; androgens; immunosuppression; lymphocyte differentiation

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• Journal Article