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Maruvada S, Liu Y, Soneson JE, et al. Comparison between experimental and computational methods for the acoustic and thermal characterization of therapeutic ultrasound fields. J Acoust Soc Am. 2015;137(4):1704-13doi: 10.1121/1.4916280.
Maruvada, S., Liu, Y., Soneson, J. E., Herman, B. A., & Harris, G. R. (2015). Comparison between experimental and computational methods for the acoustic and thermal characterization of therapeutic ultrasound fields. The Journal of the Acoustical Society of America, 137(4), 1704-13. https://doi.org/10.1121/1.4916280
Maruvada, Subha, et al. "Comparison between experimental and computational methods for the acoustic and thermal characterization of therapeutic ultrasound fields." The Journal of the Acoustical Society of America vol. 137,4 (2015): 1704-13. doi: https://doi.org/10.1121/1.4916280
Maruvada S, Liu Y, Soneson JE, Herman BA, Harris GR. Comparison between experimental and computational methods for the acoustic and thermal characterization of therapeutic ultrasound fields. J Acoust Soc Am. 2015 Apr;137(4):1704-13. doi: 10.1121/1.4916280. PMID: 25920823.
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J Acoust Soc Am. 2015 Apr;137(4):1704-13. doi: 10.1121/1.4916280.

Comparison between experimental and computational methods for the acoustic and thermal characterization of therapeutic ultrasound fields.

The Journal of the Acoustical Society of America

Subha Maruvada, Yunbo Liu, Joshua E Soneson, Bruce A Herman, Gerald R Harris

Affiliations

  1. Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993.

PMID: 25920823 DOI: 10.1121/1.4916280

Abstract

For high intensity therapeutic ultrasound (HITU) devices, pre-clinical testing can include measurement of power, pressure/intensity and temperature distribution, acoustic and thermal simulations, and assessment of targeting accuracy and treatment monitoring. Relevant International Electrotechnical Commission documents recently have been published. However, technical challenges remain because of the often focused, large amplitude pressure fields encountered. Measurement and modeling issues include using hydrophones and radiation force balances at HITU power levels, validation of simulation models, and tissue-mimicking material (TMM) development for temperature measurements. To better understand these issues, a comparison study was undertaken between simulations and measurements of the HITU acoustic field distribution in water and TMM and temperature rise in TMM. For the specific conditions of this study, the following results were obtained. In water, the simulated values for p+ and p- were 3% lower and 10% higher, respectively, than those measured by hydrophone. In TMM, the simulated values for p+ and p- were 2% and 10% higher than those measured by hydrophone, respectively. The simulated spatial-peak temporal-average intensity values in water and TMM were greater than those obtained by hydrophone by 3%. Simulated and measured end-of-sonication temperatures agreed to within their respective uncertainties (coefficients of variation of approximately 20% and 10%, respectively).

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