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Vyas P, Gonsai RN, Meenakshi C, et al. Coronary atherosclerosis in noncardiac deaths: An autopsy study. J Midlife Health. 2015;6(1):5-9doi: 10.4103/0976-7800.153596.
Vyas, P., Gonsai, R. N., Meenakshi, C., & Nanavati, M. G. (2015). Coronary atherosclerosis in noncardiac deaths: An autopsy study. Journal of mid-life health, 6(1), 5-9. https://doi.org/10.4103/0976-7800.153596
Vyas, Priti, et al. "Coronary atherosclerosis in noncardiac deaths: An autopsy study." Journal of mid-life health vol. 6,1 (2015): 5-9. doi: https://doi.org/10.4103/0976-7800.153596
Vyas P, Gonsai RN, Meenakshi C, Nanavati MG. Coronary atherosclerosis in noncardiac deaths: An autopsy study. J Midlife Health. 2015 Jan-Mar;6(1):5-9. doi: 10.4103/0976-7800.153596. PMID: 25861201; PMCID: PMC4389385.
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J Midlife Health. 2015 Jan-Mar;6(1):5-9. doi: 10.4103/0976-7800.153596.

Coronary atherosclerosis in noncardiac deaths: An autopsy study.

Journal of mid-life health

Priti Vyas, Ratigar Narangar Gonsai, Charu Meenakshi, Meeta G Nanavati

Affiliations

  1. Department of Pathology, B. J. Medical College, Ahmedabad, Gujarat, India.

PMID: 25861201 PMCID: PMC4389385 DOI: 10.4103/0976-7800.153596

Abstract

INTRODUCTION: Atherosclerosis leading to ischemic heart disease (IHD) is the most common cause of cardiac deaths worldwide. To evaluate the prevalence of atherosclerosis, an autopsy-based study conducted on subjects who died of noncardiac causes can be a valuable tool. With this hypothesis, we conducted this study on the hearts of subjects who died of noncardiac causes.

MATERIALS AND METHODS: This study was conducted from August 2012 to February 2013 at Department of Pathology, BJ Medical College, Ahmedabad, Gujarat. The deceased patients who died of noncardiac causes and underwent autopsy at our hospital, their hearts were sent to our department for histopathological analysis. The hearts were fixed in 10% formalin, weighed, measured, and the three main coronary arteries were dissected out and carefully examined for any histological evidence of atherosclerotic plaques and associated pathological lesions and graded according to the classification given by American Heart Association.

RESULTS: A total of 250 autopsy cases were evaluated. Amongst them 113 were deaths due to noncardiac causes, of which 83 (73.45%) subjects had evidence of atherosclerosis. In the study, 68 (82%) were males and 15 (18%) were females. Left anterior descending artery (LADA; 69%) was the most commonly involved coronary artery. Triple vessel disease was found in 22% of subjects.

CONCLUSION: The study showed alarmingly high prevalence of atherosclerosis. The pathogenesis of coronary atherosclerosis begins at a younger age in Indian population. Though the incidence of atherosclerosis is more common in males compared to females; coronary atherosclerosis is an important risk factor for IHDs in both sexes and screening for the same should begin at an early age.

Keywords: Atherosclerosis; autopsy; coronary vessels; left anterior descending artery; triple vessel disease

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