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Moniruzzaman M, Atikur Rahman M, Ferdous A. Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn. Evid Based Complement Alternat Med. 2015;2015:873954doi: 10.1155/2015/873954.
Moniruzzaman, M., Atikur Rahman, M., & Ferdous, A. (2015). Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn. Evidence-based complementary and alternative medicine : eCAM, 2015873954. https://doi.org/10.1155/2015/873954
Moniruzzaman, Md, et al. "Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 873954. doi: https://doi.org/10.1155/2015/873954
Moniruzzaman M, Atikur Rahman M, Ferdous A. Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn. Evid Based Complement Alternat Med. 2015;2015:873954. doi: 10.1155/2015/873954. Epub 2015 Mar 12. PMID: 25861372; PMCID: PMC4377517.
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Evid Based Complement Alternat Med. 2015;2015:873954. doi: 10.1155/2015/873954. Epub 2015 Mar 12.

Evaluation of Sedative and Hypnotic Activity of Ethanolic Extract of Scoparia dulcis Linn.

Evidence-based complementary and alternative medicine : eCAM

Md Moniruzzaman, Md Atikur Rahman, Afia Ferdous

Affiliations

  1. College of Pharmacy, Dongguk University, Goyang 410-820, Republic of Korea ; Department of Pharmacy, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka 1217, Bangladesh.
  2. Department of Pharmacy, Stamford University Bangladesh, 51 Siddeswari Road, Dhaka 1217, Bangladesh.

PMID: 25861372 PMCID: PMC4377517 DOI: 10.1155/2015/873954

Abstract

Scoparia dulcis Linn. (SD) is a perennial herb that has been well studied for its antioxidant, anti-inflammatory, antidiabetic, and hepatoprotective effects. However, scientific information on SD regarding the neuropharmacological effect is limited. This study evaluated the sedative and hypnotic effect of the ethanolic extract of whole plants of Scoparia dulcis (EESD). For this purpose, the whole plants of S. dulcis were extracted with ethanol following maceration process and tested for the presence of phytochemical constituents. The sedative and hypnotic activity were then investigated using hole cross, open field, hole-board, rota-rod, and thiopental sodium-induced sleeping time determination tests in mice at the doses of 50, 100, and 200 mg/kg of EESD. Diazepam at the dose of 1 mg/kg was used as a reference drug in all the experiments. We found that EESD produced a significant dose-dependent inhibition of locomotor activity of mice both in hole cross and open field tests (P < 0.05). Besides, it also decreased rota-rod performances and the number of head dips in hole-board test. Furthermore, EESD significantly decreased the induction time to sleep and prolonged the duration of sleeping, induced by thiopental sodium. Taken together, our study suggests that EESD may possess sedative principles with potent hypnotic properties.

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