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Huh DD. A human breathing lung-on-a-chip. Ann Am Thorac Soc. 2015;12:S42-4doi: 10.1513/AnnalsATS.201410-442MG.
Huh, D. D. (2015). A human breathing lung-on-a-chip. Annals of the American Thoracic Society, 12S42-4. https://doi.org/10.1513/AnnalsATS.201410-442MG
Huh, Dongeun Dan. "A human breathing lung-on-a-chip." Annals of the American Thoracic Society vol. 12 (2015): S42-4. doi: https://doi.org/10.1513/AnnalsATS.201410-442MG
Huh DD. A human breathing lung-on-a-chip. Ann Am Thorac Soc. 2015 Mar;12:S42-4. doi: 10.1513/AnnalsATS.201410-442MG. PMID: 25830834; PMCID: PMC5467107.
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Ann Am Thorac Soc. 2015 Mar;12:S42-4. doi: 10.1513/AnnalsATS.201410-442MG.

A human breathing lung-on-a-chip.

Annals of the American Thoracic Society

Dongeun Dan Huh

Affiliations

  1. Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.

PMID: 25830834 PMCID: PMC5467107 DOI: 10.1513/AnnalsATS.201410-442MG

Abstract

Here we describe a microphysiological system that replicates the functional unit of the living human lung. This human "breathing lung-on-a-chip" microdevice provides unique capabilities to reconstitute three-dimensional microarchitecture, dynamic mechanical activity, and integrated physiological function of the alveolar-capillary interface. We demonstrate the potential of this microengineered biomimetic model for screening environmental particulates and modeling complex human disease processes.

Keywords: lung; lung-on-a-chip; microfluidics; organ-on-a-chip

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