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Naganawa K, Takayama E, Adachi M, et al. Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients. Open Dent J. 2015;9:120-4doi: 10.2174/1874210601509010120.
Naganawa, K., Takayama, E., Adachi, M., Mitsudo, K., Iida, M., Kamiya-Mizuno, M., Kawaki, H., Ichinose, M., Motohashi, M., Muramatsu, Y., Tohnai, I., Sumitomo, S., Shikimori, M., & Kondoh, N. (2015). Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients. The open dentistry journal, 9120-4. https://doi.org/10.2174/1874210601509010120
Naganawa, Kosuke, et al. "Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients." The open dentistry journal vol. 9 (2015): 120-4. doi: https://doi.org/10.2174/1874210601509010120
Naganawa K, Takayama E, Adachi M, Mitsudo K, Iida M, Kamiya-Mizuno M, Kawaki H, Ichinose M, Motohashi M, Muramatsu Y, Tohnai I, Sumitomo S, Shikimori M, Kondoh N. Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients. Open Dent J. 2015 Mar 31;9:120-4. doi: 10.2174/1874210601509010120. eCollection 2015. PMID: 25893021; PMCID: PMC4397950.
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Open Dent J. 2015 Mar 31;9:120-4. doi: 10.2174/1874210601509010120. eCollection 2015.

Producing Capabilities of Interferon-gamma and Interleukin-10 in Peripheral Blood from Oral Squamous Cell Carcinoma Patients.

The open dentistry journal

Kosuke Naganawa, Eiji Takayama, Makoto Adachi, Kenji Mitsudo, Masaki Iida, Masako Kamiya-Mizuno, Harumi Kawaki, Masao Ichinose, Masayuki Motohashi, Yasunori Muramatsu, Iwai Tohnai, Shin-Ichiro Sumitomo, Michio Shikimori, Nobuo Kondoh

Affiliations

  1. Department of Oral Biochemistry, School of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan ; Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan.
  2. Department of Oral Biochemistry, School of Dentistry, Asahi University, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan.
  3. Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan ; Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Yokohama, Kanagawa 236-0004, Japan.
  4. Department of Oral and Maxillofacial Surgery, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Yokohama, Kanagawa 236-0004, Japan.
  5. Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, Japan.
  6. Department of Oral and Maxillofacial Surgery, School of Dentistry, Asahi University, 1851 Hozumi 1851-1, Mizuho-shi, Gifu 501-0296, Japan.

PMID: 25893021 PMCID: PMC4397950 DOI: 10.2174/1874210601509010120

Abstract

In order to evaluate the Th1 and Th2 responses of Oral Squamous Cell Carcinoma (OSCC) patients, we investigated the cytokine producing capability of peripheral blood (PB), and compared it with clinicopathological appearances of OSCC patients. The production of a Th1-type cytokine, interferon (IFN)-γ, from lipopolysaccharide (LPS)-stimulated PB correlated positively with the frequency of lymph node metastasis. We also investigated the production of a Th2-type cytokine, IL-10, however, no significant correlation was observed with the clinicopathological appearances. Our results suggested that the IFN-γ producing capability was specifically regulated and dependent on the regional metastatic potencies of OSCCs.

Keywords: Cytokine-producing capability; Oral squamous cell carcinoma; interferon-gamma (IFN-γ); peripheral blood; tumor immunology

References

  1. Support Care Cancer. 2011 Sep;19(9):1303-11 - PubMed
  2. Front Immunol. 2013 Jan 28;4:11 - PubMed
  3. Eur J Oral Sci. 2014 Jun;122(3):202-9 - PubMed
  4. Philos Trans R Soc Lond B Biol Sci. 1982 Sep 24;299(1094):77-90 - PubMed
  5. Arch Otolaryngol Head Neck Surg. 1986 May;112(5):545-51 - PubMed
  6. J Allergy Clin Immunol. 1995 Oct;96(4):515-27 - PubMed
  7. J Immunol. 2001 Sep 1;167(5):2972-8 - PubMed
  8. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Feb;117(2):163-9 - PubMed
  9. Dis Colon Rectum. 2006 Apr;49(4):507-16 - PubMed
  10. J Oral Maxillofac Surg. 2009 May;67(5):1015-20 - PubMed
  11. Cancer Immunol Immunother. 1996 Jan;42(1):1-8 - PubMed
  12. Surgery. 1995 Apr;117(4):365-72 - PubMed
  13. J Immunol. 2000 Jul 1;165(1):139-47 - PubMed
  14. Cancer Immunol Immunother. 2006 Jun;55(6):734-43 - PubMed
  15. Annu Rev Immunol. 2004;22:329-60 - PubMed
  16. J Immunol. 1996 Sep 15;157(6):2712-8 - PubMed
  17. Oncol Rep. 2011 Jul;26(1):201-8 - PubMed

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