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Boding L, Hansen AK, Nielsen MM, et al. Midline 1 controls polarization and migration of murine cytotoxic T cells. Immun Inflamm Dis. 2015;2(4):262-71doi: 10.1002/iid3.44.
Boding, L., Hansen, A. K., Nielsen, M. M., Meroni, G., Braunstein, T. H., Woetmann, A., Ødum, N., Bonefeld, C. M., & Geisler, C. (2014). Midline 1 controls polarization and migration of murine cytotoxic T cells. Immunity, inflammation and disease, 2(4), 262-71. https://doi.org/10.1002/iid3.44
Boding, Lasse, et al. "Midline 1 controls polarization and migration of murine cytotoxic T cells." Immunity, inflammation and disease vol. 2,4 (2014): 262-71. doi: https://doi.org/10.1002/iid3.44
Boding L, Hansen AK, Nielsen MM, Meroni G, Braunstein TH, Woetmann A, Ødum N, Bonefeld CM, Geisler C. Midline 1 controls polarization and migration of murine cytotoxic T cells. Immun Inflamm Dis. 2014 Dec;2(4):262-71. doi: 10.1002/iid3.44. Epub 2015 Jan 27. PMID: 25866633; PMCID: PMC4386920.
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Immun Inflamm Dis. 2014 Dec;2(4):262-71. doi: 10.1002/iid3.44. Epub 2015 Jan 27.

Midline 1 controls polarization and migration of murine cytotoxic T cells.

Immunity, inflammation and disease

Lasse Boding, Ann K Hansen, Morten M Nielsen, Germana Meroni, Thomas H Braunstein, Anders Woetmann, Niels Ødum, Charlotte M Bonefeld, Carsten Geisler

Affiliations

  1. Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen Copenhagen, Denmark.
  2. Institute for Maternal and Child Health-IRCCS "Burlo Garofolo" Trieste, Italy.
  3. Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen Copenhagen, Denmark.

PMID: 25866633 PMCID: PMC4386920 DOI: 10.1002/iid3.44

Abstract

Midline 1 (MID1) is a microtubule-associated ubiquitin ligase that regulates protein phosphatase 2 A levels. Loss-of-function mutations in MID1 lead to the human X-linked Opitz G/BBB (OS) syndrome characterized by defective midline development during embryogenesis. We have recently shown that MID1 is strongly up-regulated in murine cytotoxic T lymphocytes (CTLs), and that it has a significant impact on exocytosis of lytic granules and the killing capacity of CTLs. The aims of the present study were to determine the localization of MID1 in migrating CTLs, and to investigate whether MID1 affects CTL polarization and migration. We found that MID1 mainly localizes to the uropod of migrating CTLs and that it has a substantial impact on CTL polarization and migration in vitro. Furthermore, analysis of contact hypersensitivity responses supported that MID1 controls effector functions of CTLs in hapten-challenged skin in vivo. These results provide significant new knowledge on the role of MID1 in CTL biology.

Keywords: CTLs; Midline 1; contact hypersensitivity; microtubule; migration

References

  1. Contact Dermatitis. 2007 Nov;57(5):300-8 - PubMed
  2. Front Immunol. 2013 Apr 08;4:84 - PubMed
  3. J Immunol. 2006 Nov 15;177(10):6852-8 - PubMed
  4. Proc Natl Acad Sci U S A. 2005 May 10;102(19):6884-9 - PubMed
  5. J Immunol. 1984 Nov;133(5):2762-6 - PubMed
  6. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2794-9 - PubMed
  7. Eur J Immunol. 2011 Jul;41(7):1948-57 - PubMed
  8. Nat Immunol. 2006 Nov;7(11):1143-9 - PubMed
  9. Br J Dermatol. 2010 Jan;162(1):102-7 - PubMed
  10. J Immunol. 2006 Jun 15;176(12):7502-10 - PubMed
  11. Nat Med. 2013 Feb;19(2):232-7 - PubMed
  12. PLoS One. 2010 Jan 19;5(1):e8774 - PubMed
  13. PLoS One. 2013 Nov 18;8(11):e80500 - PubMed
  14. Cell Motil Cytoskeleton. 2006 Jul;63(7):415-22 - PubMed
  15. Am J Med Genet A. 2003 Jul 15;120A(2):222-8 - PubMed
  16. PLoS One. 2008;3(10 ):e3507 - PubMed
  17. Nature. 1990 Aug 16;346(6285):629-33 - PubMed
  18. Nat Genet. 1997 Nov;17(3):285-91 - PubMed
  19. J Exp Med. 1996 Mar 1;183(3):1001-12 - PubMed
  20. Br J Dermatol. 2014 Feb;170(2):352-9 - PubMed
  21. J Immunol. 2012 Sep 1;189(5):2191-202 - PubMed
  22. Contact Dermatitis. 2014 May;70(5):282-90 - PubMed
  23. Bioessays. 2003 Apr;25(4):356-66 - PubMed
  24. Nat Genet. 2001 Nov;29(3):287-94 - PubMed
  25. Biochem Soc Trans. 2009 Oct;37(Pt 5):1007-13 - PubMed
  26. J Immunol. 1997 Aug 1;159(3):1063-7 - PubMed
  27. Eur J Immunol. 2014 Oct;44(10):3109-18 - PubMed
  28. J Cell Biol. 2004 Oct 25;167(2):327-37 - PubMed
  29. J Neurosci. 2010 Feb 24;30(8):2880-7 - PubMed
  30. Eur J Immunol. 1995 Nov;25(11):3006-10 - PubMed
  31. Mol Biol Cell. 2002 Dec;13(12):4470-83 - PubMed
  32. Trends Cell Biol. 2005 Feb;15(2):76-83 - PubMed
  33. J Immunol. 2014 Apr 1;192(7):2975-83 - PubMed
  34. Semin Cell Dev Biol. 2011 Dec;22(9):968-74 - PubMed
  35. Science. 2003 Dec 5;302(5651):1704-9 - PubMed
  36. Contact Dermatitis. 2011 Dec;65(6):336-42 - PubMed
  37. Hum Mol Genet. 1999 Aug;8(8):1387-96 - PubMed
  38. J Immunol. 1990 Jun 1;144(11):4121-8 - PubMed
  39. EMBO J. 1999 Feb 1;18(3):501-11 - PubMed
  40. J Immunol. 2008 Dec 1;181(11):7786-99 - PubMed
  41. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6650-5 - PubMed

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