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Mannic T, Viguie J, Rossier MF. In vivo and in vitro evidences of dehydroepiandrosterone protective role on the cardiovascular system. Int J Endocrinol Metab. 2015;13(2):e24660doi: 10.5812/ijem.24660.
Mannic, T., Viguie, J., & Rossier, M. F. (2015). In vivo and in vitro evidences of dehydroepiandrosterone protective role on the cardiovascular system. International journal of endocrinology and metabolism, 13(2), e24660. https://doi.org/10.5812/ijem.24660
Mannic, Tiphaine, et al. "In vivo and in vitro evidences of dehydroepiandrosterone protective role on the cardiovascular system." International journal of endocrinology and metabolism vol. 13,2 (2015): e24660. doi: https://doi.org/10.5812/ijem.24660
Mannic T, Viguie J, Rossier MF. In vivo and in vitro evidences of dehydroepiandrosterone protective role on the cardiovascular system. Int J Endocrinol Metab. 2015 Apr 30;13(2):e24660. doi: 10.5812/ijem.24660. eCollection 2015 Apr. PMID: 25926854; PMCID: PMC4389253.
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Int J Endocrinol Metab. 2015 Apr 30;13(2):e24660. doi: 10.5812/ijem.24660. eCollection 2015 Apr.

In vivo and in vitro evidences of dehydroepiandrosterone protective role on the cardiovascular system.

International journal of endocrinology and metabolism

Tiphaine Mannic, Joanna Viguie, Michel Florian Rossier

Affiliations

  1. Department of Human Protein Science, Faculty of Medicine, University of Geneva, Geneva, Switzerland ; Department of Genetics and laboratory Medicine, University Hospitals of Geneva, University of Geneva, Geneva, Switzerland.
  2. Department of Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  3. Department of Human Protein Science, Faculty of Medicine, University of Geneva, Geneva, Switzerland ; Service of Clinical Chemistry and Toxicology, Central Institute of the Hospital of Valais, Sion, Switzerland.

PMID: 25926854 PMCID: PMC4389253 DOI: 10.5812/ijem.24660

Abstract

CONTEXT: Dehydroepiandrosterone (DHEA) and its sulfate ester, Dehydroepiandrosterone Sulfate (DHEA-S) have been considered as putative anti-aging hormones for many years. Indeed, while DHEAS is the most abundant circulating hormone, its concentration is markedly decreased upon aging and early epidemiologic trials have revealed a strong inverse correlation between the hormone concentrations and the occurrence of several dysfunctions frequently encountered in the elderly. Naturally, hormonal supplementation has been rapidly suggested to prevent DHEA (S) deficiency and therefore, age-related development of these pathologies, using the same strategy as estrogen replacement therapy proposed in postmenopausal women.

EVIDENCE ACQUISITION: All references were searched using PubMed and the following strategy: our initial selection included all articles in English and we sorted them with the following keywords: "DHEA or DHEA-S" and "heart or vascular or endothelium or cardiovascular disease". The search was limited to neither the publication date nor specific journals. The final selection was made according to the relevance of the article content with the aims of the review. According to these criteria, fewer than 10% of the articles retrieved at the first step were discarded.

RESULTS: In this short review, we have focused on the cardiovascular action of DHEA. We started by analyzing evidences in favor of a strong inverse association between DHEA (S) levels and the cardiovascular risk as demonstrated in multiple observational epidemiologic studies for several decades. Then we discussed the different trials aimed at supplementing DHEA (S), both in animals and human, for preventing cardiovascular diseases and we analyzed the possible reasons for the discrepancy observed among the results of some studies. Finally, we presented putative molecular mechanisms of action for DHEA (S), demonstrated in vitro in different models of vascular and cardiac cells, highlighting the complexity of the involved signaling pathways.

CONCLUSIONS: The identification of the beneficial cardiovascular effects of DHEA (S) and a better understanding of the involved mechanisms should be helpful to develop new strategies or pharmacologic approaches for many lethal diseases in Western countries.

Keywords: Cardiovascular System; Dehydroepiandrosterone; Disease; Endothelium; Myocytes, Cardiac; Steroids

References

  1. Clin Endocrinol (Oxf). 2013 Apr;78(4):629-34 - PubMed
  2. Endocrinology. 2006 Dec;147(12):5967-74 - PubMed
  3. Diabet Med. 2012 Jul;29(7):e41-6 - PubMed
  4. Vascul Pharmacol. 2008 Feb-Mar;48(2-3):76-84 - PubMed
  5. J Clin Endocrinol Metab. 2004 Sep;89(9):4708-15 - PubMed
  6. Endocrinology. 2008 Jan;149(1):380-8 - PubMed
  7. Hypertens Res. 2008 Jan;31(1):69-74 - PubMed
  8. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8145-50 - PubMed
  9. Clin Chem. 2013 Sep;59(9):1338-48 - PubMed
  10. Adv Med Sci. 2007;52 Suppl 1:126-30 - PubMed
  11. Steroids. 2012 Feb;77(3):233-40 - PubMed
  12. Biochem Pharmacol. 2013 Mar 15;85(6):718-26 - PubMed
  13. N Engl J Med. 1986 Dec 11;315(24):1519-24 - PubMed
  14. J Clin Endocrinol Metab. 2003 Jul;88(7):3190-5 - PubMed
  15. N Engl J Med. 2003 Apr 3;348(14):1309-21 - PubMed
  16. Atherosclerosis. 2010 Sep;212(1):310-5 - PubMed
  17. Circulation. 2009 Sep 29;120(13):1231-40 - PubMed
  18. Reprod Sci. 2012 Jan;19(1):86-91 - PubMed
  19. Cardiovasc Res. 2007 Jun 1;74(3):377-87 - PubMed
  20. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1798-809 - PubMed
  21. Cardiovasc Ther. 2011 Aug;29(4):219-30 - PubMed
  22. Exp Gerontol. 2002 May;37(5):701-12 - PubMed
  23. Steroids. 2004 Apr;69(4):279-89 - PubMed
  24. Aging Cell. 2012 Oct;11(5):876-84 - PubMed
  25. Ann Intern Med. 1998 Oct 1;129(7):588 - PubMed
  26. Endocrinology. 2013 Mar;154(3):1271-81 - PubMed
  27. Curr Opin Endocrinol Diabetes Obes. 2011 Jun;18(3):171-6 - PubMed
  28. Circulation. 2004 Sep 28;110(13):1787-93 - PubMed
  29. Steroids. 2011 Dec 20;76(14):1590-6 - PubMed
  30. Atherosclerosis. 2007 Jan;190(1):90-9 - PubMed
  31. J Pharmacol Exp Ther. 2002 Apr;301(1):299-305 - PubMed
  32. Stroke. 2013 Jul;44(7):1784-9 - PubMed
  33. J Mol Cell Cardiol. 2002 Jun;34(6):679-88 - PubMed
  34. Horm Metab Res. 2012 Jul;44(8):625-31 - PubMed
  35. Eur Respir J. 2012 Dec;40(6):1420-9 - PubMed
  36. J Clin Endocrinol Metab. 2002 Aug;87(8):3632-9 - PubMed
  37. Clin Endocrinol (Oxf). 2012 Sep;77(3):423-9 - PubMed
  38. FEBS J. 2005 Mar;272(6):1343-53 - PubMed
  39. Life Sci. 2009 Jul 3;85(1-2):77-84 - PubMed
  40. Int J Cardiol. 2010 Sep 3;143(3):343-8 - PubMed
  41. Biochem Pharmacol. 2012 Jun 1;83(11):1530-9 - PubMed
  42. Ann N Y Acad Sci. 1995 Dec 29;774:271-80 - PubMed
  43. J Clin Endocrinol Metab. 2010 Nov;95(11):4985-92 - PubMed
  44. J Clin Pharmacol. 1999 Apr;39(4):327-48 - PubMed
  45. Am J Epidemiol. 2001 Jan 1;153(1):79-89 - PubMed

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