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Youn I, Choi SH, Kook SH, et al. Ultrasonography-guided surgical clip placement for tumor localization in patients undergoing neoadjuvant chemotherapy for breast cancer. J Breast Cancer. 2015;18(1):44-9doi: 10.4048/jbc.2015.18.1.44.
Youn, I., Choi, S. H., Kook, S. H., Choi, Y. J., Park, C. H., Park, Y. L., & Kim, D. H. (2015). Ultrasonography-guided surgical clip placement for tumor localization in patients undergoing neoadjuvant chemotherapy for breast cancer. Journal of breast cancer, 18(1), 44-9. https://doi.org/10.4048/jbc.2015.18.1.44
Youn, Inyoung, et al. "Ultrasonography-guided surgical clip placement for tumor localization in patients undergoing neoadjuvant chemotherapy for breast cancer." Journal of breast cancer vol. 18,1 (2015): 44-9. doi: https://doi.org/10.4048/jbc.2015.18.1.44
Youn I, Choi SH, Kook SH, Choi YJ, Park CH, Park YL, Kim DH. Ultrasonography-guided surgical clip placement for tumor localization in patients undergoing neoadjuvant chemotherapy for breast cancer. J Breast Cancer. 2015 Mar;18(1):44-9. doi: 10.4048/jbc.2015.18.1.44. Epub 2015 Mar 27. PMID: 25834610; PMCID: PMC4381122.
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J Breast Cancer. 2015 Mar;18(1):44-9. doi: 10.4048/jbc.2015.18.1.44. Epub 2015 Mar 27.

Ultrasonography-guided surgical clip placement for tumor localization in patients undergoing neoadjuvant chemotherapy for breast cancer.

Journal of breast cancer

Inyoung Youn, Seon Hyeong Choi, Shin Ho Kook, Yoon Jung Choi, Chan Heun Park, Yong Lai Park, Dong Hoon Kim

Affiliations

  1. Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  2. Department of Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
  3. Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

PMID: 25834610 PMCID: PMC4381122 DOI: 10.4048/jbc.2015.18.1.44

Abstract

PURPOSE: We investigated the feasibility of using surgical clips as markers for tumor localization and their effect on the imaging evaluation of treatment responses after neoadjuvant chemotherapy (NAC).

METHODS: A total of 16 breast cancers confirmed by needle biopsy in 15 patients were included in this study from October 2012 to June 2014. Under ultrasonography (US)-guidance, the surgical clips were placed prior to NAC. Additional mammography, breast US, and breast magnetic resonance examinations were performed within 10 days before surgery. The time period from marker insertion to operation date was documented. Images acquired via the three modalities were evalu-ated for the following parameters: location of clip, clip migration (>1 cm), the presence of complications from clip placement, and the effect of clips on the assessment of treatment.

RESULTS: The mean time period was 128.6±34.4 days (median, 132.0 days) from the date of clip insertion to the date of surgery. The mean number of inserted clips was 2.3±0.7 (median, 2.0). Clip migration was not visualized by imaging in any patient, and there were no complications reported. Surgical clips did not negatively affect the assessment of treatment responses to NAC.

CONCLUSION: Surgical clips may replace commercial tissue markers for tumor localization in breast cancer patients undergoing NAC without migration. Surgical clips are well tolerated and safe for the patient, easily visualized on imaging, do not interfere with treatment response, and are cost-effective.

Keywords: Breast neoplasms; Image-guided biopsy; Neoadjuvant therapy; Surgical instruments; Ultrasonography

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