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Mohrmann C, Henry J, Hauff M, et al. Neurocognitive outcomes and school performance in solid tumor cancer survivors lacking therapy to the central nervous system. J Pers Med. 2015;5(2):83-90doi: 10.3390/jpm5020083.
Mohrmann, C., Henry, J., Hauff, M., & Hayashi, R. J. (2015). Neurocognitive outcomes and school performance in solid tumor cancer survivors lacking therapy to the central nervous system. Journal of personalized medicine, 5(2), 83-90. https://doi.org/10.3390/jpm5020083
Mohrmann, Caroline, et al. "Neurocognitive outcomes and school performance in solid tumor cancer survivors lacking therapy to the central nervous system." Journal of personalized medicine vol. 5,2 (2015): 83-90. doi: https://doi.org/10.3390/jpm5020083
Mohrmann C, Henry J, Hauff M, Hayashi RJ. Neurocognitive outcomes and school performance in solid tumor cancer survivors lacking therapy to the central nervous system. J Pers Med. 2015 Apr 10;5(2):83-90. doi: 10.3390/jpm5020083. PMID: 25867598; PMCID: PMC4493487.
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J Pers Med. 2015 Apr 10;5(2):83-90. doi: 10.3390/jpm5020083.

Neurocognitive outcomes and school performance in solid tumor cancer survivors lacking therapy to the central nervous system.

Journal of personalized medicine

Caroline Mohrmann, Jennifer Henry, Marnie Hauff, Robert J Hayashi

Affiliations

  1. Washington University School of Medicine, 1 Children's Place, Campus Box 8116 Saint Louis, MO 63110, USA. [email protected].
  2. Washington University School of Medicine, 1 Children's Place, Campus Box 8116 Saint Louis, MO 63110, USA. [email protected].
  3. Washington University School of Medicine, 1 Children's Place, Campus Box 8116 Saint Louis, MO 63110, USA. [email protected].
  4. Washington University School of Medicine, 1 Children's Place, Campus Box 8116 Saint Louis, MO 63110, USA. [email protected].

PMID: 25867598 PMCID: PMC4493487 DOI: 10.3390/jpm5020083

Abstract

School performance in patients who have received therapy for childhood cancers has been studied in depth. Risk factors have historically included cranial radiation, intrathecal chemotherapy, and high doses of chemotherapy, including methotrexate and cytarabine. Leukemia and brain tumor survivors who receive such therapy have been the primary focus of this area of investigation. Extracranial solid tumor cancer patients lacking such risk factors have historically been expected to have normal school performance. We examined the medical records of 58 young pediatric extracranial solid tumor patients who lacked CNS-directed therapy or other known risk factors for cognitive impairment to evaluate the incidence of reported difficulties or abnormalities in neuropsychological testing. Thirty-one percent of patients were found to have at least one reported difficulty or abnormality. Of note, 34% of patients with Wilms tumor possessed difficulties compared to 23% of patients with other extracranial solid tumors. Extracranial solid tumor cancer survivors without known risk factors for school performance difficulties appear to have a higher incidence of problems than expected.

References

  1. Pediatr Blood Cancer. 2011 Jul 15;57(1):126-34 - PubMed
  2. Arch Dis Child. 2000 May;82(5):353-7 - PubMed
  3. Cancer. 2006 May 1;106(9):2067-75 - PubMed
  4. J Natl Cancer Inst. 2010 Jun 16;102(12):881-93 - PubMed
  5. Pediatr Blood Cancer. 2007 Jul;49(1):65-73 - PubMed
  6. J Clin Oncol. 2013 Dec 10;31(35):4407-15 - PubMed
  7. J Clin Oncol. 2007 Aug 10;25(23):3518-24 - PubMed
  8. J Pediatr Psychol. 2012 Jul;37(6):660-73 - PubMed
  9. J Natl Cancer Inst. 2010 Feb 24;102(4):254-70 - PubMed
  10. Cancer. 2003 Feb 15;97(4):1115-26 - PubMed
  11. Cancer Epidemiol Biomarkers Prev. 2011 Sep;20(9):1838-49 - PubMed
  12. Neuropsychology. 2009 Nov;23(6):705-17 - PubMed
  13. Neuro Oncol. 2013 Nov;15(11):1543-51 - PubMed
  14. Arch Phys Med Rehabil. 2008 Jan;89(1):128-36 - PubMed
  15. Neurotoxicology. 2009 Nov;30(6):1019-24 - PubMed

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