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Meinhardt K, Kroeger I, Bauer R, et al. Identification and characterization of the specific murine NK cell subset supporting graft-. Oncoimmunology. 2015;4(1):e981483doi: 10.4161/2162402X.2014.981483.
Meinhardt, K., Kroeger, I., Bauer, R., Ganss, F., Ovsiy, I., Rothamer, J., Büttner, M., Atreya, I., Waldner, M., Bittrich, M., Lehmann, C. H., Rieger, M. A., Beilhack, A., Zeiser, R., Edinger, M., Dudziak, D., Mackensen, A., Rehli, M., & Ullrich, E. (2015). Identification and characterization of the specific murine NK cell subset supporting graft-. Oncoimmunology, 4(1), e981483. https://doi.org/10.4161/2162402X.2014.981483
Meinhardt, Kathrin, et al. "Identification and characterization of the specific murine NK cell subset supporting graft-." Oncoimmunology vol. 4,1 (2015): e981483. doi: https://doi.org/10.4161/2162402X.2014.981483
Meinhardt K, Kroeger I, Bauer R, Ganss F, Ovsiy I, Rothamer J, Büttner M, Atreya I, Waldner M, Bittrich M, Lehmann CH, Rieger MA, Beilhack A, Zeiser R, Edinger M, Dudziak D, Mackensen A, Rehli M, Ullrich E. Identification and characterization of the specific murine NK cell subset supporting graft-. Oncoimmunology. 2015 Feb 03;4(1):e981483. doi: 10.4161/2162402X.2014.981483. eCollection 2015 Jan. PMID: 25949862; PMCID: PMC4368119.
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Oncoimmunology. 2015 Feb 03;4(1):e981483. doi: 10.4161/2162402X.2014.981483. eCollection 2015 Jan.

Identification and characterization of the specific murine NK cell subset supporting graft-.

Oncoimmunology

Kathrin Meinhardt, Irena Kroeger, Ruth Bauer, Franziska Ganss, Ilja Ovsiy, Johanna Rothamer, Maike Büttner, Imke Atreya, Maximilian Waldner, Max Bittrich, Christian Hk Lehmann, Michael A Rieger, Andreas Beilhack, Robert Zeiser, Matthias Edinger, Diana Dudziak, Andreas Mackensen, Michael Rehli, Evelyn Ullrich

Affiliations

  1. Department of Internal Medicine 5; Hematology and Oncology; Friedrich-Alexander Universität Erlangen-Nürnberg; University Hospital Erlangen ; Erlangen, Germany ; Childrens Hospital; Department of Pediatric Hematology and Oncology; Johann Wolfgang Goethe University ; Frankfurt, Germany ; LOEWE Center for Cell and Gene Therapy; Johann Wolfgang Goethe University ; Frankfurt, Germany.
  2. Department of Internal Medicine 5; Hematology and Oncology; Friedrich-Alexander Universität Erlangen-Nürnberg; University Hospital Erlangen ; Erlangen, Germany.
  3. Childrens Hospital; Department of Pediatric Hematology and Oncology; Johann Wolfgang Goethe University ; Frankfurt, Germany ; LOEWE Center for Cell and Gene Therapy; Johann Wolfgang Goethe University ; Frankfurt, Germany.
  4. Department of Nephropathology; Friedrich-Alexander Universität Erlangen-Nürnberg; University Hospital Erlangen ; Erlangen, Germany.
  5. Department of Internal Medicine 1; Friedrich-Alexander Universität Erlangen-Nürnberg; University Hospital Erlangen ; Erlangen, Germany.
  6. Department of Dermatology; Laboratory of Dendritic Cell Biology; Friedrich-Alexander Universität Erlangen-Nürnberg; University Hospital Erlangen ; Erlangen, Germany.
  7. LOEWE Center for Cell and Gene Therapy; Johann Wolfgang Goethe University ; Frankfurt, Germany ; Department of Hematology/Oncology; Johann Wolfgang Goethe University ; Frankfurt, Germany.
  8. IZKF Research Group for Experimental Stem Cell Transplantation; Department of Medicine II; University Hospital ; Würzburg, Germany.
  9. Division of Hematology and Oncology; Department of Medicine; Freiburg University Medical Center; Albert-Ludwigs-University ; Freiburg, Germany.
  10. Department of Internal Medicine 3; University Hospital Regensburg ; Regensburg; Germany ; Regensburg Center for Interventional Immunology (RCI); University Regensburg ; Regensburg, Germany.

PMID: 25949862 PMCID: PMC4368119 DOI: 10.4161/2162402X.2014.981483

Abstract

Clinical studies investigating the impact of natural killer (NK) cells in allogeneic hematopoietic stem cell transplantation settings have yielded promising results. However, NK cells are a functionally and phenotypically heterogeneous population. Therefore, we addressed the functional relevance of specific NK cell subsets distinguished by expression of CD117, CD27 and CD11b surface markers in graft-versus-leukemia (GVL)-reaction and graft-versus-host-disease (GVHD). Our results clearly demonstrate that the subset of c-Kit

Keywords: BMT, bone marrow transplantation; CD11b+ NK = c-Kit−CD27−CD11b+ NK cells; CD27+ NK = c-Kit−CD27+CD11b− NK cells; DP = c-Kit−CD27+CD11b+ NK cells; GVHD; GVHD, graft-versus-host disease; GVL; GVL, graft-versus-leukemia; HSCT, hematopoietic stem cell transplantation; KIR, killer cell immunoglobulin-like receptor; MLR, mixed lymphocyte reaction; NK cells; NK, natural killer; TBI, total body irradiation; c-Kit+ NK = c-Kit+CD27+CD11b− NK cells; stem cell transplantation; tumor immunology

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