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Bento DC, Jones E, Junaid S, et al. High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression. Oncoimmunology. 2015;4(3):e974374doi: 10.4161/2162402X.2014.974374.
Bento, D. C., Jones, E., Junaid, S., Tull, J., Williams, G. T., Godkin, A., Ager, A., & Gallimore, A. (2015). High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression. Oncoimmunology, 4(3), e974374. https://doi.org/10.4161/2162402X.2014.974374
Bento, Diana Costa, et al. "High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression." Oncoimmunology vol. 4,3 (2015): e974374. doi: https://doi.org/10.4161/2162402X.2014.974374
Bento DC, Jones E, Junaid S, Tull J, Williams GT, Godkin A, Ager A, Gallimore A. High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression. Oncoimmunology. 2015 Apr 02;4(3):e974374. doi: 10.4161/2162402X.2014.974374. eCollection 2015 Mar. PMID: 25949892; PMCID: PMC4404788.
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Oncoimmunology. 2015 Apr 02;4(3):e974374. doi: 10.4161/2162402X.2014.974374. eCollection 2015 Mar.

High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression.

Oncoimmunology

Diana Costa Bento, Emma Jones, Syed Junaid, Justyna Tull, Geraint T Williams, Andrew Godkin, Ann Ager, Awen Gallimore

Affiliations

  1. Infection and Immunity; School of Medicine; Henry Wellcome Building; Cardiff University ; Cardiff, UK.
  2. Institute of Medical Genetics; University Hospital of Wales ; Cardiff, UK.
  3. Institute of Cancer and Genetics; Cardiff University School of Medicine ; Cardiff, UK.

PMID: 25949892 PMCID: PMC4404788 DOI: 10.4161/2162402X.2014.974374

Abstract

Prolonged patient survival after surgical resection, is associated with a higher cytotoxic and memory T cell density within colorectal cancers (CRC). High endothelial venules (HEVs) are specialized blood vessels present in secondary lymphoid organs (SLO) that allow ingress of naïve and central memory T cells from the blood. It has been proposed that HEVs in tumors might serve as a similar route of entry for lymphocytes into the tumor and result in an improved prognosis. The present study aimed to characterize HEVs and their microenvironment in resected tumors from colorectal cancer patients (

Keywords: A/F, aggregate/ follicle; CRC, colorectal cancer; HEV, high endothelial venule; T cells; TILs, tumor-infiltrating lymphocytes; Treg, regulatory T cell.; colorectal cancer; high endothelial venules; lymphoid aggregates/follicles; tumor infiltrating lymphocytes and tertiary lymphoid organs

References

  1. N Engl J Med. 2005 Dec 22;353(25):2654-66 - PubMed
  2. Br J Cancer. 2005 May 9;92(9):1746-53 - PubMed
  3. Cancer Res. 1998 Aug 15;58(16):3491-4 - PubMed
  4. Cancer Res. 2012 Nov 1;72(21):5473-82 - PubMed
  5. Cancer Res. 2011 Sep 1;71(17):5678-87 - PubMed
  6. Mod Pathol. 2005 May;18(5):681-5 - PubMed
  7. Cancer Sci. 2010 Nov;101(11):2302-8 - PubMed
  8. Histopathology. 2013 Dec;63(6):852-61 - PubMed
  9. Mucosal Immunol. 2014 Mar;7(2):428-39 - PubMed
  10. Gut. 2012 Aug;61(8):1163-71 - PubMed
  11. Clin Cancer Res. 2014 Apr 15;20(8):2147-58 - PubMed
  12. World J Gastroenterol. 2012 Aug 7;18(29):3839-48 - PubMed
  13. Science. 2006 Sep 29;313(5795):1960-4 - PubMed
  14. Cancer Sci. 2011 May;102(5):1088-94 - PubMed
  15. Lancet. 2014 Apr 26;383(9927):1490-502 - PubMed
  16. Int J Cancer. 2014 May 1;134(9):2126-35 - PubMed
  17. PLoS One. 2006 Dec 27;1:e129 - PubMed
  18. Oncoimmunology. 2012 Sep 1;1(6):829-839 - PubMed
  19. Nature. 2011 Nov 13;479(7374):542-6 - PubMed
  20. Immunol Today. 1995 Sep;16(9):449-57 - PubMed
  21. Gastroenterology. 2010 Jun;138(6):2073-2087.e3 - PubMed
  22. Nature. 1999 Oct 14;401(6754):708-12 - PubMed
  23. CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 - PubMed
  24. N Engl J Med. 2005 Feb 3;352(5):476-87 - PubMed
  25. Cancer Res. 2011 Oct 15;71(20):6391-9 - PubMed
  26. Front Immunol. 2012 Nov 30;3:350 - PubMed

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