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Choi MR, Kouyoumdzian NM, Rukavina Mikusic NL, et al. Renal dopaminergic system: Pathophysiological implications and clinical perspectives. World J Nephrol. 2015;4(2):196-212doi: 10.5527/wjn.v4.i2.196.
Choi, M. R., Kouyoumdzian, N. M., Rukavina Mikusic, N. L., Kravetz, M. C., Rosón, M. I., Rodríguez Fermepin, M., & Fernández, B. E. (2015). Renal dopaminergic system: Pathophysiological implications and clinical perspectives. World journal of nephrology, 4(2), 196-212. https://doi.org/10.5527/wjn.v4.i2.196
Choi, Marcelo Roberto, et al. "Renal dopaminergic system: Pathophysiological implications and clinical perspectives." World journal of nephrology vol. 4,2 (2015): 196-212. doi: https://doi.org/10.5527/wjn.v4.i2.196
Choi MR, Kouyoumdzian NM, Rukavina Mikusic NL, Kravetz MC, Rosón MI, Rodríguez Fermepin M, Fernández BE. Renal dopaminergic system: Pathophysiological implications and clinical perspectives. World J Nephrol. 2015 May 06;4(2):196-212. doi: 10.5527/wjn.v4.i2.196. PMID: 25949933; PMCID: PMC4419129.
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World J Nephrol. 2015 May 06;4(2):196-212. doi: 10.5527/wjn.v4.i2.196.

Renal dopaminergic system: Pathophysiological implications and clinical perspectives.

World journal of nephrology

Marcelo Roberto Choi, Nicolás Martín Kouyoumdzian, Natalia Lucía Rukavina Mikusic, María Cecilia Kravetz, María Inés Rosón, Martín Rodríguez Fermepin, Belisario Enrique Fernández

Affiliations

  1. Marcelo Roberto Choi, Department of Anatomy and Histology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, CONICET, INFIBIOC, Buenos Aires 1113, Argentina.

PMID: 25949933 PMCID: PMC4419129 DOI: 10.5527/wjn.v4.i2.196

Abstract

Fluid homeostasis, blood pressure and redox balance in the kidney are regulated by an intricate interaction between local and systemic anti-natriuretic and natriuretic systems. Intrarenal dopamine plays a central role on this interactive network. By activating specific receptors, dopamine promotes sodium excretion and stimulates anti-oxidant and anti-inflammatory pathways. Different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome, hypertension and renal inflammation, can be associated with impaired action of renal dopamine including alteration in biosynthesis, dopamine receptor expression and signal transduction. Given its properties on the regulation of renal blood flow and sodium excretion, exogenous dopamine has been postulated as a potential therapeutic strategy to prevent renal failure in critically ill patients. The aim of this review is to update and discuss on the most recent findings about renal dopaminergic system and its role in several diseases involving the kidneys and the potential use of dopamine as a nephroprotective agent.

Keywords: D1 receptors; D2 receptors; Dopamine; Edema; Hypertension; Na+, K+-ATPase; Oxidative stress; Renal failure; Sodium; kidney

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