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Barretti P, Doles JV, Pinotti DG, et al. Evidence-based medicine: An update on treatments for peritoneal dialysis-related peritonitis. World J Nephrol. 2015;4(2):287-94doi: 10.5527/wjn.v4.i2.287.
Barretti, P., Doles, J. V., Pinotti, D. G., & El Dib, R. P. (2015). Evidence-based medicine: An update on treatments for peritoneal dialysis-related peritonitis. World journal of nephrology, 4(2), 287-94. https://doi.org/10.5527/wjn.v4.i2.287
Barretti, Pasqual, et al. "Evidence-based medicine: An update on treatments for peritoneal dialysis-related peritonitis." World journal of nephrology vol. 4,2 (2015): 287-94. doi: https://doi.org/10.5527/wjn.v4.i2.287
Barretti P, Doles JV, Pinotti DG, El Dib RP. Evidence-based medicine: An update on treatments for peritoneal dialysis-related peritonitis. World J Nephrol. 2015 May 06;4(2):287-94. doi: 10.5527/wjn.v4.i2.287. PMID: 25949943; PMCID: PMC4419139.
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World J Nephrol. 2015 May 06;4(2):287-94. doi: 10.5527/wjn.v4.i2.287.

Evidence-based medicine: An update on treatments for peritoneal dialysis-related peritonitis.

World journal of nephrology

Pasqual Barretti, João Vitor Pereira Doles, Douglas Gonçalves Pinotti, Regina Paolucci El Dib

Affiliations

  1. Pasqual Barretti, Department of Internal Medicine, Botucatu Medical School, UNESP, 18618000 Botucatu, Sao Paulo, Brazil.

PMID: 25949943 PMCID: PMC4419139 DOI: 10.5527/wjn.v4.i2.287

Abstract

Peritonitis continues to be a major complication of peritoneal dialysis (PD), and adequate treatment is crucial for a favorable outcome. There is no consensus regarding the optimal therapeutic regimen, and few prospective controlled studies have been published. The objective of this manuscript is to review the results of PD peritonitis treatment reported in narrative reviews, systematic reviews, and proportional meta-analyses. Two narrative reviews, the only existing systematic review and its update published between 1991 and 2014 were included. In addition, we reported the results of a proportional meta-analysis published by our group. Results from systematic reviews of randomized control trials (RCT) and quasi-RCT were not able to identify any optimal antimicrobial treatment, but glycopeptide regimens were more likely to achieve a complete cure than a first generation cephalosporin. Compared to urokinase, simultaneous catheter removal and replacement resulted in better outcomes. Continuous and intermittent IP antibiotic use had similar outcomes. Intraperitoneal antibiotics were superior to intravenous antibiotics in reducing treatment failure. In the proportional meta-analysis of RCTs and the case series, the resolution rate (86%) of ceftazidime plus glycopeptide as initial treatment was significantly higher than first generation cephalosporin plus aminoglycosides (66%) and glycopeptides plus aminoglycosides (75%). Other comparisons of regimens used for either initial treatment or treatment of gram-positive rods or gram-negative rods did not show statistically significant differences. The superiority of a combination of a glycopeptide and a third generation cephalosporin was also reported by a narrative review study published in 1991, which reported an 88% resolution rate.

Keywords: Antibiotic; Peritoneal dialysis; Peritonitis; Treatment

References

  1. Perit Dial Int. 1996 May-Jun;16(3):316-8 - PubMed
  2. Clin Nephrol. 1992 Apr;37(4):209-13 - PubMed
  3. J Antimicrob Chemother. 1990 Dec;26 Suppl F:77-81 - PubMed
  4. Ren Fail. 2007;29(2):177-81 - PubMed
  5. Perit Dial Int. 1993;13 Suppl 2:S348-50 - PubMed
  6. Adv Perit Dial. 2011;27:38-42 - PubMed
  7. J Antimicrob Chemother. 1990 Dec;26 Suppl F:73-6 - PubMed
  8. Perit Dial Int. 1997 Jan-Feb;17(1):87-9 - PubMed
  9. Nephrol Dial Transplant. 2007 Jun;22(6):1714-9 - PubMed
  10. Am J Kidney Dis. 2001 Jan;37(1):49-55 - PubMed
  11. Contrib Nephrol. 1991;89:108-18 - PubMed
  12. Adv Perit Dial. 1997;13:218-20 - PubMed
  13. BMC Infect Dis. 2009 Dec 22;9:212 - PubMed
  14. Perit Dial Int. 1989;9(4):247-56 - PubMed
  15. Adv Perit Dial. 2004;20:74-7 - PubMed
  16. Perit Dial Int. 2000 Jul-Aug;20(4):396-411 - PubMed
  17. Postgrad Med J. 1967 Aug;43:Suppl 43:160-5 - PubMed
  18. Am J Kidney Dis. 2001 Jul;38(1):127-31 - PubMed
  19. Clin Nephrol. 2011 May;75(5):416-25 - PubMed
  20. Clin J Am Soc Nephrol. 2008 Jan;3(1):91-7 - PubMed
  21. Perit Dial Int. 2010 Jul-Aug;30(4):393-423 - PubMed
  22. Adv Perit Dial. 1989;5:128-9 - PubMed
  23. Perit Dial Int. 2000 Mar-Apr;20(2):232-4 - PubMed
  24. Perit Dial Int. 1991;11(1):27-30 - PubMed
  25. Perit Dial Int. 1999 Jan-Feb;19(1):88-9 - PubMed
  26. Perit Dial Int. 2001 Sep-Oct;21(5):480-6 - PubMed
  27. J Antimicrob Chemother. 1997 Nov;40(5):729-32 - PubMed
  28. Perit Dial Int. 1993;13(1):14-28 - PubMed
  29. BJU Int. 2012 Aug;110(4):510-6 - PubMed
  30. Perit Dial Int. 1996 Nov-Dec;16(6):557-73 - PubMed
  31. Perit Dial Int. 2009 Mar-Apr;29(2):230-3 - PubMed
  32. Ther Apher Dial. 2010 Apr;14(2):201-8 - PubMed
  33. J Antimicrob Chemother. 1990 May;25(5):843-51 - PubMed
  34. Perit Dial Int. 1995 Jul-Sep;15(6):269-71 - PubMed
  35. Perit Dial Int. 1991;11(3):252-60 - PubMed
  36. Perit Dial Int. 2005 Mar-Apr;25(2):107-31 - PubMed
  37. Perit Dial Int. 2009 May-Jun;29(3):297-302 - PubMed
  38. Nephrology (Carlton). 2005 Apr;10(2):142-6 - PubMed
  39. J Antimicrob Chemother. 1990 Dec;26 Suppl F:63-71 - PubMed
  40. Perit Dial Int. 1995;15(2):167-71 - PubMed
  41. Nephron. 1989;51(1):51-5 - PubMed
  42. Am J Kidney Dis. 2007 Dec;50(6):967-88 - PubMed
  43. Cochrane Database Syst Rev. 2014 Apr 26;(4):CD005284 - PubMed
  44. Perit Dial Int. 1991;11(1):31-7 - PubMed
  45. Int Urol Nephrol. 2012 Oct;44(5):1529-37 - PubMed
  46. Perit Dial Int. 2004 Sep-Oct;24(5):424-32 - PubMed
  47. PLoS One. 2014 Jun 02;9(6):e98006 - PubMed
  48. Clin J Am Soc Nephrol. 2014 Jun 6;9(6):1074-81 - PubMed
  49. Am J Kidney Dis. 1990 Feb;15(2):155-9 - PubMed
  50. Perit Dial Int. 2004 Sep-Oct;24(5):440-6 - PubMed
  51. Adv Perit Dial. 1992;8:234-7 - PubMed
  52. J Nephrol. 1999 Sep-Oct;12(5):318-21 - PubMed
  53. Kidney Int Suppl. 2006 Nov;(103):S44-54 - PubMed
  54. Perit Dial Int. 2004 Sep-Oct;24(5):433-9 - PubMed
  55. BMC Infect Dis. 2014 Aug 18;14:445 - PubMed
  56. Perit Dial Int. 1998 Jul-Aug;18(4):371-5 - PubMed
  57. J Clin Microbiol. 1988 Sep;26(9):1757-62 - PubMed
  58. Perit Dial Int. 2011 Nov-Dec;31(6):639-50 - PubMed
  59. J Antimicrob Chemother. 1988 Jan;21 Suppl A:133-9 - PubMed
  60. Perit Dial Int. 1997 Jan-Feb;17(1):91-4 - PubMed
  61. Lancet. 1993 Feb 20;341(8843):497 - PubMed
  62. Perit Dial Int. 2003 Sep-Oct;23(5):456-9 - PubMed

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