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Staten PL, Hines JF, Kost ER, et al. A descriptive evaluation with follow-up of the clinical significance of atypical immature squamous metaplasia of the cervix. J Low Genit Tract Dis. 2000;4(1):30-3doi: 10.1046/j.1526-0976.2000.41006.x.
Staten, P. L., Hines, J. F., Kost, E. R., Fish, M., Rouse, E., & Hall, K. L. (2000). A descriptive evaluation with follow-up of the clinical significance of atypical immature squamous metaplasia of the cervix. Journal of lower genital tract disease, 4(1), 30-3. https://doi.org/10.1046/j.1526-0976.2000.41006.x
Staten, P L, et al. "A descriptive evaluation with follow-up of the clinical significance of atypical immature squamous metaplasia of the cervix." Journal of lower genital tract disease vol. 4,1 (2000): 30-3. doi: https://doi.org/10.1046/j.1526-0976.2000.41006.x
Staten PL, Hines JF, Kost ER, Fish M, Rouse E, Hall KL. A descriptive evaluation with follow-up of the clinical significance of atypical immature squamous metaplasia of the cervix. J Low Genit Tract Dis. 2000 Jan;4(1):30-3. doi: 10.1046/j.1526-0976.2000.41006.x. PMID: 25950788.
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J Low Genit Tract Dis. 2000 Jan;4(1):30-3. doi: 10.1046/j.1526-0976.2000.41006.x.

A descriptive evaluation with follow-up of the clinical significance of atypical immature squamous metaplasia of the cervix.

Journal of lower genital tract disease

P L Staten, J F Hines, E R Kost, M Fish, E Rouse, K L Hall

Affiliations

  1. *Departments of Obstetrics and Gynecology and †Pathology, Brooke Army Medical Center, Fort Sam Houston, and the ‡Department of Pathology, Wilford Hall Medical Center, Lackland AFB, TX.

PMID: 25950788 DOI: 10.1046/j.1526-0976.2000.41006.x

Abstract

OBJECTIVES: We set out to determine the clinical significance of atypical immature squamous metaplasia (AIM).

METHODS: We performed in a military, hospital-based colposcopy clinic a descriptive, retrospective review of patients who had a diagnosis of AIM. Patients were examined at 3- to 4-month intervals for at least 1 year after a diagnosis of AIM was established. A gynecological pathologist reviewed all histological and cytological specimens. Initial histological or cytological specimens were tested for the presence of HPV DNA using in situ hybridization.

RESULTS: High-risk HPV DNA types 16 or 18 were detected in 3% of patients with AIM. Concurrent cervical intraepithelial neoplasia 3 (CIN3) was noted in 3% of patients with AIM. One-third of patients with initially diagnosed AIM had complete resolution of this lesion after 1 year of follow-up.

CONCLUSIONS: This descriptive, retrospective review shows that AIM does not appear to be associated with high-risk HPV DNA or with CIN3. In this limited study, a concurrent diagnosis of AIM likely does not influence the 1-year behavior of CIN. The degree of CIN should dictate treatment recommendations. A larger prospective trial is needed.

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