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J Hum Reprod Sci. 2015 Jan-Mar;8(1):3-13. doi: 10.4103/0974-1208.153119.

Fertility preservation in female cancer patients: An overview.

Journal of human reproductive sciences

Nalini Mahajan

Affiliations

  1. Department of Reproductive Medicine, Nova IVI Fertilit, New Delhi, India.

PMID: 25838742 PMCID: PMC4381379 DOI: 10.4103/0974-1208.153119

Abstract

Fertility preservation is becoming increasingly important to improve the quality of life in cancer survivors. Despite guidelines suggesting that discussion of fertility preservation should be done prior to starting cancer therapies, there is a lack of implementation in this area. A number of techniques are available for fertility preservation, and they can be used individually or together in the same patient to maximize efficiency. Oocyte and embryo cryopreservation are now established techniques but have their limitations. Ovarian tissue cryopreservation though considered experimental at present, has a wider clinical application and the advantage of keeping the fertility window open for a longer time. Both chemotherapy and radiotherapy have a major impact on reproductive potential and fertility preservation procedures should be carried out prior to these treatments. The need for fertility preservation has to be weighed against morbidity and mortality associated with cancer. There is thus a need for a multidisciplinary collaboration between oncologists and reproductive specialists to improve awareness and availability.

Keywords: Cancer; counseling; cryopreservation; fertility preservation

References

  1. Fertil Steril. 2011 Jan;95(1):342-4 - PubMed
  2. Gynecol Oncol. 1992 Dec;47(3):348-52 - PubMed
  3. J Assist Reprod Genet. 2012 Jun;29(6):465-8 - PubMed
  4. Int J Radiat Oncol Biol Phys. 2005 Jul 1;62(3):738-44 - PubMed
  5. Fertil Steril. 2009 Aug;92(2):458-63 - PubMed
  6. Hum Reprod. 2006 Oct;21(10 ):2583-92 - PubMed
  7. J Natl Cancer Inst Monogr. 2005;(34):21-5 - PubMed
  8. Br J Cancer. 2011 Oct 25;105(9):1288-94 - PubMed
  9. Clin Obstet Gynecol. 2010 Dec;53(4):727-39 - PubMed
  10. Med Pediatr Oncol. 1999 Jul;33(1):29-33 - PubMed
  11. Acta Obstet Gynecol Scand. 2011 Nov;90(11):1200-9 - PubMed
  12. Best Pract Res Clin Obstet Gynaecol. 2010 Feb;24(1):87-100 - PubMed
  13. J Clin Oncol. 2005 Jul 1;23(19):4347-53 - PubMed
  14. Cancer Treat Rev. 2001 Feb;27(1):1-7 - PubMed
  15. Curr Oncol. 2013 Dec;20(6):e602-7 - PubMed
  16. Cancer Epidemiol Biomarkers Prev. 2009 Aug;18(8):2239-47 - PubMed
  17. Soc Sci Med. 2008 Feb;66(3):784-9 - PubMed
  18. Clin Transl Oncol. 2008 May;10(5):268-73 - PubMed
  19. Fertil Steril. 2010 Nov;94(6):2186-90 - PubMed
  20. Fertil Steril. 2013 Dec;100(6):1673-80 - PubMed
  21. Semin Reprod Med. 2011 Mar;29(2):147-54 - PubMed
  22. J Assist Reprod Genet. 2015 Apr;32(4):587-96 - PubMed
  23. N Engl J Med. 2009 Jun 18;360(25):2682; author reply 2682-3 - PubMed
  24. J Clin Oncol. 2009 May 10;27(14):2374-81 - PubMed
  25. Am J Obstet Gynecol. 2003 Feb;188(2):367-70 - PubMed
  26. J Obstet Gynaecol. 2011;31(1):13-7 - PubMed
  27. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):737-42 - PubMed
  28. Expert Opin Pharmacother. 2011 Feb;12(3):387-96 - PubMed
  29. Fertil Steril. 2013 Nov;100(5):1214-23 - PubMed
  30. Ultrasound Obstet Gynecol. 1996 Nov;8(5):341-5 - PubMed
  31. Obstet Gynecol Surv. 2011 Jul;66(7):443-51 - PubMed
  32. Hum Reprod Update. 2001 Nov-Dec;7(6):535-43 - PubMed
  33. J Clin Oncol. 2006 Jun 20;24(18):2917-31 - PubMed
  34. Am J Epidemiol. 1999 Aug 1;150(3):245-54 - PubMed
  35. Hum Reprod. 2007 Jun;22(6):1626-33 - PubMed
  36. Clin Breast Cancer. 2005 Dec;6(5):421-4 - PubMed
  37. Fertil Steril. 2004 Oct;82(4):993-8 - PubMed
  38. Cochrane Database Syst Rev. 2011 Nov 09;(11):CD008018 - PubMed
  39. Am J Obstet Gynecol. 2002 Oct;187(4):1070-80 - PubMed
  40. J Assist Reprod Genet. 2012 Jun;29(6):489-93 - PubMed
  41. J Assist Reprod Genet. 2013 Oct;30(10):1263-70 - PubMed
  42. J Toxicol Sci. 2009;34 Suppl 1:SP73-81 - PubMed
  43. J Clin Oncol. 2011 Mar 20;29(9):1110-6 - PubMed
  44. Fertil Steril. 2013 May;99(6):1534-42 - PubMed
  45. Fertil Steril. 2008 Jun;89(6):1657-64 - PubMed
  46. Clin Obstet Gynecol. 2010 Dec;53(4):804-14 - PubMed
  47. Fertil Steril. 2012 Nov;98(5):1225-8 - PubMed
  48. Nat Med. 2009 Oct;15(10):1124-5 - PubMed
  49. Hum Reprod Update. 2014 Sep-Oct;20(5):759-74 - PubMed
  50. Gynecol Endocrinol. 2013 Nov;29(11):993-6 - PubMed
  51. Fertil Steril. 2013 Jan;99(1):37-43 - PubMed
  52. Oncologist. 2007 Sep;12(9):1044-54 - PubMed
  53. Mutat Res. 1995 Oct;339(3):155-76 - PubMed
  54. Acta Obstet Gynecol Scand. 2004 Jan;83(1):96-102 - PubMed
  55. Hum Reprod. 2013 Nov;28(11):2996-9 - PubMed
  56. Ultrasound Obstet Gynecol. 1995 Sep;6(3):175-81 - PubMed
  57. Hum Reprod. 2010 Jan;25(1):66-73 - PubMed
  58. Biomed Res Int. 2014;2014:482968 - PubMed
  59. Acta Obstet Gynecol Scand. 2015 Mar;94(3):324-8 - PubMed

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