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Mishra A, Kumar R, Tyagi A, et al. Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer. Ecancermedicalscience. 2015;9:525doi: 10.3332/ecancer.2015.525.
Mishra, A., Kumar, R., Tyagi, A., Kohaar, I., Hedau, S., Bharti, A. C., Sarker, S., Dey, D., Saluja, D., & Das, B. (2015). Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer. Ecancermedicalscience, 9525. https://doi.org/10.3332/ecancer.2015.525
Mishra, Alok, et al. "Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer." Ecancermedicalscience vol. 9 (2015): 525. doi: https://doi.org/10.3332/ecancer.2015.525
Mishra A, Kumar R, Tyagi A, Kohaar I, Hedau S, Bharti AC, Sarker S, Dey D, Saluja D, Das B. Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer. Ecancermedicalscience. 2015 Apr 23;9:525. doi: 10.3332/ecancer.2015.525. eCollection 2015. PMID: 25932049; PMCID: PMC4407748.
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Ecancermedicalscience. 2015 Apr 23;9:525. doi: 10.3332/ecancer.2015.525. eCollection 2015.

Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer.

Ecancermedicalscience

Alok Mishra, Rakesh Kumar, Abhishek Tyagi, Indu Kohaar, Suresh Hedau, Alok C Bharti, Subhodeep Sarker, Dipankar Dey, Daman Saluja, Bhudev Das

Affiliations

  1. Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India ; National Cancer Institute, NIH, Bethesda, MD, USA 20892.
  2. Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India ; Mayo Clinic, Rochester, MN, USA 55905 ; Rakesh Kumar deceased.
  3. Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India.
  4. Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; National Cancer Institute, NIH, Bethesda, MD, USA 20892.
  5. Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India.
  6. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India.
  7. Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India ; Amity University, Noida 201303, India.

PMID: 25932049 PMCID: PMC4407748 DOI: 10.3332/ecancer.2015.525

Abstract

In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.

Keywords: activator protein-1 (AP-1); curcumin; human papilloma virus (HPA); nuclear factor kappaB (NF-kB); transcription

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