Display options
Cite
Cattaneo A, Macchi F, Plazzotta G, et al. Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis. Front Cell Neurosci. 2015;9:40doi: 10.3389/fncel.2015.00040.
Cattaneo, A., Macchi, F., Plazzotta, G., Veronica, B., Bocchio-Chiavetto, L., Riva, M. A., & Pariante, C. M. (2015). Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis. Frontiers in cellular neuroscience, 940. https://doi.org/10.3389/fncel.2015.00040
Cattaneo, Annamaria, et al. "Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis." Frontiers in cellular neuroscience vol. 9 (2015): 40. doi: https://doi.org/10.3389/fncel.2015.00040
Cattaneo A, Macchi F, Plazzotta G, Veronica B, Bocchio-Chiavetto L, Riva MA, Pariante CM. Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis. Front Cell Neurosci. 2015 Mar 31;9:40. doi: 10.3389/fncel.2015.00040. eCollection 2015. PMID: 25873859; PMCID: PMC4379909.
Copy Download .nbib Format: NLM
Share it on

Front Cell Neurosci. 2015 Mar 31;9:40. doi: 10.3389/fncel.2015.00040. eCollection 2015.

Inflammation and neuronal plasticity: a link between childhood trauma and depression pathogenesis.

Frontiers in cellular neuroscience

Annamaria Cattaneo, Flavia Macchi, Giona Plazzotta, Begni Veronica, Luisella Bocchio-Chiavetto, Marco Andrea Riva, Carmine Maria Pariante

Affiliations

  1. Stress, Psychiatry and Immunology Laboratory, Department of Psychological Medicine, Institute of Psychiatry, King's College London London, UK ; IRCCS Centro S Giovanni di Dio, Fatebenefratelli Brescia, Italy.
  2. Department of Pharmacological and Biomolecular Sciences, University of Milan Milan, Italy.
  3. IRCCS Centro S Giovanni di Dio, Fatebenefratelli Brescia, Italy.
  4. IRCCS Centro S Giovanni di Dio, Fatebenefratelli Brescia, Italy ; Faculty of Psychology, eCampus University Novedrate (Como), Italy.
  5. Stress, Psychiatry and Immunology Laboratory, Department of Psychological Medicine, Institute of Psychiatry, King's College London London, UK.

PMID: 25873859 PMCID: PMC4379909 DOI: 10.3389/fncel.2015.00040

Abstract

During the past two decades, there has been increasing interest in understanding and characterizing the role of inflammation in major depressive disorder (MDD). Indeed, several are the evidences linking alterations in the inflammatory system to Major Depression, including the presence of elevated levels of pro-inflammatory cytokines, together with other mediators of inflammation. However, it is still not clear whether inflammation represents a cause or whether other factors related to depression result in these immunological effects. Regardless, exposure to early life stressful events, which represent a vulnerability factor for the development of psychiatric disorders, act through the modulation of inflammatory responses, but also of neuroplastic mechanisms over the entire life span. Indeed, early life stressful events can cause, possibly through epigenetic changes that persist over time, up to adulthood. Such alterations may concur to increase the vulnerability to develop psychopathologies. In this review we will discuss the role of inflammation and neuronal plasticity as relevant processes underlying depression development. Moreover, we will discuss the role of epigenetics in inducing alterations in inflammation-immune systems as well as dysfunction in neuronal plasticity, thus contributing to the long-lasting negative effects of stressful life events early in life and the consequent enhanced risk for depression. Finally we will provide an overview on the potential role of inflammatory system to aid diagnosis, predict treatment response, enhance treatment matching, and prevent the onset or relapse of Major Depression.

Keywords: childhood trauma; depression; inflammation; neuroplasticity; stress

References

  1. Biol Psychiatry. 2007 Mar 1;61(5):661-70 - PubMed
  2. Mol Cell Neurosci. 2009 Oct;42(2):81-9 - PubMed
  3. Front Neurosci. 2013 Aug 20;7:145 - PubMed
  4. Mol Psychiatry. 2002;7(6):609-16 - PubMed
  5. Child Dev. 2013 Jan-Feb;84(1):49-57 - PubMed
  6. Biol Psychiatry. 2006 Jun 15;59(12):1116-27 - PubMed
  7. Prog Neurobiol. 2008 May;85(1):1-74 - PubMed
  8. Prog Neurobiol. 2005 Jun;76(2):99-125 - PubMed
  9. Ann Clin Psychiatry. 2007 Oct-Dec;19(4):289-303 - PubMed
  10. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Jul;30(5):899-905 - PubMed
  11. Mol Psychiatry. 2014 Jun;19(6):699-709 - PubMed
  12. J Clin Psychiatry. 2005 Jan;66(1):41-8 - PubMed
  13. J Neurosci. 2011 Oct 26;31(43):15511-21 - PubMed
  14. Neuropsychopharmacology. 2000 Apr;22(4):370-9 - PubMed
  15. J Interpers Violence. 2014 Jan 23;29(12 ):2257-2272 - PubMed
  16. Endocr Rev. 1996 Feb;17(1):64-102 - PubMed
  17. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13632-7 - PubMed
  18. Dev Neurobiol. 2010 Apr;70(5):289-97 - PubMed
  19. Neuropsychopharmacology. 2013 Feb;38(3):377-85 - PubMed
  20. Brain Behav Immun. 2006 Mar;20(2):169-74 - PubMed
  21. J Child Psychol Psychiatry. 2013 Aug;54(8):816-35 - PubMed
  22. Prog Neuropsychopharmacol Biol Psychiatry. 1995 Jan;19(1):11-38 - PubMed
  23. Child Dev. 2013 Jan-Feb;84(1):58-75 - PubMed
  24. Am J Psychiatry. 2014 Dec 1;171(12):1278-86 - PubMed
  25. Arch Pediatr Adolesc Med. 2009 Dec;163(12):1135-43 - PubMed
  26. Psychosom Med. 2009 Feb;71(2):171-86 - PubMed
  27. Biol Psychiatry. 2003 Apr 15;53(8):707-42 - PubMed
  28. Ann N Y Acad Sci. 1995 Jul 21;762:474-6 - PubMed
  29. Mol Psychiatry. 2014 Jul;19(7):791-800 - PubMed
  30. World J Biol Psychiatry. 2010 Sep;11(6):763-73 - PubMed
  31. Psychosom Med. 2007 Jun;69(5):402-9 - PubMed
  32. J Affect Disord. 2013 Sep 25;150(3):736-44 - PubMed
  33. Front Psychiatry. 2014 Jan 22;5:5 - PubMed
  34. Psychopharmacology (Berl). 2003 Dec;170(4):429-33 - PubMed
  35. J Psychosom Res. 2014 Aug;77(2):104-8 - PubMed
  36. Neurobiol Dis. 2010 Mar;37(3):747-55 - PubMed
  37. Arch Intern Med. 2004 May 10;164(9):1010-4 - PubMed
  38. Am J Psychiatry. 2005 Jan;162(1):175-7 - PubMed
  39. Br J Psychiatry. 2006 Mar;188:216-22 - PubMed
  40. J Affect Disord. 1996 Jul 8;39(2):149-55 - PubMed
  41. Ann Epidemiol. 2009 Apr;19(4):264-7 - PubMed
  42. Neuropsychopharmacology. 2012 Mar;37(4):929-38 - PubMed
  43. Curr Psychiatry Rep. 2014 Jan;16(1):429 - PubMed
  44. Psychiatr Clin North Am. 2014 Jun;37(2):183-94 - PubMed
  45. Nature. 2008 Oct 16;455(7215):894-902 - PubMed
  46. Nat Rev Neurosci. 2006 Feb;7(2):137-51 - PubMed
  47. Psychosom Med. 2003 May-Jun;65(3):347-56 - PubMed
  48. Neuropsychopharmacology. 2007 Nov;32(11):2351-9 - PubMed
  49. Child Maltreat. 2014 Aug-Nov;19(3-4):156-67 - PubMed
  50. Life Sci. 1983 Jul 18;33(3):241-7 - PubMed
  51. Pharmacol Ther. 2008 Jan;117(1):30-51 - PubMed
  52. Psychopharmacology (Berl). 2011 May;215(2):267-75 - PubMed
  53. Psychol Med. 2014 Oct;44(14):2927-37 - PubMed
  54. Front Cell Neurosci. 2014 May 13;8:129 - PubMed
  55. JAMA. 1998 Dec 2;280(21):1855-62 - PubMed
  56. Dialogues Clin Neurosci. 2005;7(2):103-23 - PubMed
  57. Eur J Neurosci. 2006 Sep;24(5):1477-87 - PubMed
  58. Am J Psychiatry. 2006 Sep;163(9):1630-3 - PubMed
  59. Paediatr Child Health. 2013 Oct;18(8):415-8 - PubMed
  60. Soc Psychiatry Psychiatr Epidemiol. 2009 Mar;44(3):217-22 - PubMed
  61. Eur J Pharmacol. 2004 Oct 1;500(1-3):399-411 - PubMed
  62. Mol Psychiatry. 2011 Jul;16(7):751-62 - PubMed
  63. Eur Neuropsychopharmacol. 2013 Sep;23(9):1105-14 - PubMed
  64. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Feb;29(2):201-17 - PubMed
  65. Nat Neurosci. 2009 Dec;12(12):1559-66 - PubMed
  66. Annu Rev Clin Psychol. 2005;1:409-38 - PubMed
  67. J Affect Disord. 1995 Dec 24;36(1-2):29-36 - PubMed
  68. J Leukoc Biol. 2012 Nov;92(5):959-75 - PubMed
  69. JAMA. 2009 Sep 16;302(11):1167; author reply 1167-8 - PubMed
  70. Int J Neuropsychopharmacol. 2014 Oct;17(10):1599-608 - PubMed
  71. Psychoneuroendocrinology. 1995;20(2):111-6 - PubMed
  72. J Neurosci. 2011 Mar 23;31(12):4475-83 - PubMed
  73. Neuropharmacology. 2012 Jan;62(1):3-12 - PubMed
  74. Int J Neuropsychopharmacol. 2013 Apr;16(3):631-45 - PubMed
  75. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11032-7 - PubMed
  76. Neuropsychopharmacology. 2001 Dec;25(6):836-44 - PubMed
  77. Arch Gen Psychiatry. 2010 Mar;67(3):258-67 - PubMed
  78. Handb Exp Pharmacol. 2014;220:461-79 - PubMed
  79. Eur Arch Psychiatry Clin Neurosci. 1997;247(4):228-33 - PubMed
  80. Biol Psychiatry. 2004 Apr 1;55(7):708-14 - PubMed
  81. J Psychiatry Neurosci. 2004 May;29(3):196-205 - PubMed
  82. Neural Plast. 2014;2014:610343 - PubMed
  83. Psychol Med. 2004 Nov;34(8):1475-82 - PubMed
  84. Can J Psychiatry. 2013 Dec;58(12):697-704 - PubMed
  85. Neuropharmacology. 2003 Jun;44(7):903-10 - PubMed
  86. Front Neuroendocrinol. 2005 Oct-Dec;26(3-4):139-62 - PubMed
  87. J Neurosci. 2011 Dec 7;31(49):17835-47 - PubMed
  88. Neurosci Biobehav Rev. 2009 Apr;33(4):573-85 - PubMed
  89. Nat Rev Neurosci. 2008 Jan;9(1):46-56 - PubMed
  90. Science. 2003 Aug 8;301(5634):805-9 - PubMed
  91. J Affect Disord. 2012 Aug;139(3):230-9 - PubMed
  92. PLoS One. 2013;8(3):e57700 - PubMed
  93. J Neurobiol. 1998 Aug;36(2):287-306 - PubMed
  94. Int J Ment Health Syst. 2014 Apr 01;8(1):12 - PubMed
  95. J Immunol. 2008 Nov 15;181(10 ):6797-802 - PubMed
  96. Metab Brain Dis. 2009 Mar;24(1):27-53 - PubMed
  97. Clin Chem. 2004 Mar;50(3):574-81 - PubMed
  98. J Clin Psychiatry. 2014 Oct;75(10):1034-9 - PubMed
  99. Nat Neurosci. 2007 Sep;10(9):1089-93 - PubMed
  100. Exp Neurol. 2015 Jun;268:10-20 - PubMed
  101. Biol Psychiatry. 2010 Mar 1;67(5):446-57 - PubMed
  102. Int J Neuropsychopharmacol. 2002 Dec;5(4):389-99 - PubMed
  103. Am J Psychiatry. 1999 Jul;156(7):1120 - PubMed
  104. Neuron. 2008 Aug 14;59(3):349-51 - PubMed
  105. Neuropsychopharmacology. 2007 Jul;32(7):1504-19 - PubMed
  106. Neurobiol Learn Mem. 2008 Mar;89(3):312-23 - PubMed
  107. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jan 3;48:304-13 - PubMed
  108. FASEB J. 2003 Aug;17(11):1556-8 - PubMed
  109. Nat Neurosci. 2006 Apr;9(4):519-25 - PubMed
  110. Schizophr Res. 2015 Jan;161(1):102-12 - PubMed
  111. Psychiatry Res. 2008 Aug 15;160(2):192-9 - PubMed
  112. Biol Psychiatry. 2001 Mar 1;49(5):391-404 - PubMed
  113. Mol Psychiatry. 2007 Dec;12(12):1079-88 - PubMed
  114. BMC Neurosci. 2007 Dec 19;8:107 - PubMed
  115. Int J Neuropsychopharmacol. 2006 Jun;9(3):307-17 - PubMed
  116. Nat Rev Neurosci. 2005 Jun;6(6):463-75 - PubMed
  117. PLoS One. 2012;7(8):e42676 - PubMed
  118. J Pediatr. 2014 Mar;164(3):631-8.e1-2 - PubMed
  119. Psychoneuroendocrinology. 2009 Dec;34 Suppl 1:S208-16 - PubMed
  120. Pharmacol Ther. 2011 Oct;132(1):39-56 - PubMed
  121. Neuropsychopharmacology. 2008 Jan;33(1):88-109 - PubMed
  122. J Psychiatry Neurosci. 2015 Jan;40(1):5-18 - PubMed
  123. Am J Psychiatry. 2004 Apr;161(4):631-6 - PubMed
  124. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15945-50 - PubMed
  125. Psychol Med. 2006 Jan;36(1):37-43 - PubMed
  126. Curr Opin Neurobiol. 2015 Feb;30:31-7 - PubMed
  127. Neurosci Biobehav Rev. 2011 Jan;35(3):599-611 - PubMed
  128. J Affect Disord. 2009 May;115(1-2):177-82 - PubMed
  129. J ECT. 2003 Dec;19(4):183-8 - PubMed
  130. J Affect Disord. 1995 Aug 18;34(4):301-9 - PubMed
  131. Nat Rev Neurosci. 2005 Aug;6(8):603-14 - PubMed
  132. J Neurosci. 2003 Jan 1;23(1):349-57 - PubMed
  133. Transl Psychiatry. 2014 Aug 26;4:e429 - PubMed
  134. Biol Psychiatry. 2003 Nov 15;54(10):1025-34 - PubMed
  135. Eur Neuropsychopharmacol. 2014 Jun;24(6):986-95 - PubMed
  136. Biol Psychiatry. 2012 Jul 1;72(1):34-40 - PubMed
  137. Eur Arch Psychiatry Clin Neurosci. 1995;244(6):325-9 - PubMed
  138. Biol Psychiatry. 2004 Dec 1;56(11):819-24 - PubMed
  139. Biol Psychiatry. 2009 May 1;65(9):732-41 - PubMed
  140. Nat Neurosci. 2009 Mar;12(3):342-8 - PubMed
  141. Adv Neurobiol. 2015 ;10 :335-61 - PubMed
  142. Cell. 2008 Jul 11;134(1):175-87 - PubMed
  143. J Clin Gastroenterol. 2006 Apr;40(4):322-35 - PubMed
  144. Front Cell Neurosci. 2014 Mar 11;8:75 - PubMed
  145. Neuropsychopharmacology. 2008 Jan;33(1):3-17 - PubMed
  146. Public Health Rep. 2014 May;129(3):222-8 - PubMed
  147. Eur J Neurosci. 2004 Sep;20(5):1348-54 - PubMed
  148. Nat Neurosci. 2004 Aug;7(8):841-6 - PubMed
  149. Science. 2003 Dec 5;302(5651):1760-5 - PubMed
  150. Arch Gen Psychiatry. 2008 Apr;65(4):409-15 - PubMed
  151. J Neurosci. 2012 Oct 31;32(44):15626-42 - PubMed
  152. Mol Psychiatry. 2015 May;20(5):621-31 - PubMed
  153. J Neurochem. 2005 Jun;93(6):1551-60 - PubMed
  154. J Child Sex Abus. 2014;23(7):804-23 - PubMed
  155. Brain Behav Immun. 2013 May;30:186-94 - PubMed
  156. Hum Psychopharmacol. 2005 Oct;20(7):473-6 - PubMed
  157. Neurosci Biobehav Rev. 2013 Jun;37(5):831-45 - PubMed
  158. Neuropsychobiology. 1997;35(3):123-7 - PubMed
  159. Neurobiol Dis. 2013 Apr;52:24-37 - PubMed
  160. Brain Behav Immun. 2012 Mar;26(3):469-79 - PubMed
  161. J Am Acad Child Adolesc Psychiatry. 1996 Nov;35(11):1427-39 - PubMed
  162. J Neurosci. 2005 Feb 2;25(5):1089-94 - PubMed
  163. J Affect Disord. 1995 Apr 16;34(1):61-9 - PubMed
  164. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1623-30 - PubMed
  165. Curr Opin Psychiatry. 2013 Jan;26(1):19-26 - PubMed
  166. J Pak Med Assoc. 2013 Jul;63(7):899-906 - PubMed
  167. Neuropharmacology. 2012 Jan;62(1):264-9 - PubMed
  168. Proc Natl Acad Sci U S A. 2013 May 14;110(20):8302-7 - PubMed
  169. CNS Drugs. 2010 Jan;24(1):1-7 - PubMed
  170. Biol Psychiatry. 2009 May 1;65(9):760-9 - PubMed
  171. Nature. 2011 Jun 15;475(7354):91-5 - PubMed
  172. PLoS One. 2011;6(12):e28330 - PubMed

Publication Types

Grant support