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Toyoda G, Bokura H, Mitaki S, et al. Association of mild kidney dysfunction with silent brain lesions in neurologically normal subjects. Cerebrovasc Dis Extra. 2015;5(1):22-7doi: 10.1159/000373916.
Toyoda, G., Bokura, H., Mitaki, S., Onoda, K., Oguro, H., Nagai, A., & Yamaguchi, S. (2015). Association of mild kidney dysfunction with silent brain lesions in neurologically normal subjects. Cerebrovascular diseases extra, 5(1), 22-7. https://doi.org/10.1159/000373916
Toyoda, Genya, et al. "Association of mild kidney dysfunction with silent brain lesions in neurologically normal subjects." Cerebrovascular diseases extra vol. 5,1 (2015): 22-7. doi: https://doi.org/10.1159/000373916
Toyoda G, Bokura H, Mitaki S, Onoda K, Oguro H, Nagai A, Yamaguchi S. Association of mild kidney dysfunction with silent brain lesions in neurologically normal subjects. Cerebrovasc Dis Extra. 2015 Feb 27;5(1):22-7. doi: 10.1159/000373916. eCollection 2015. PMID: 25873927; PMCID: PMC4376920.
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Cerebrovasc Dis Extra. 2015 Feb 27;5(1):22-7. doi: 10.1159/000373916. eCollection 2015.

Association of mild kidney dysfunction with silent brain lesions in neurologically normal subjects.

Cerebrovascular diseases extra

Genya Toyoda, Hirokazu Bokura, Shingo Mitaki, Keiichi Onoda, Hiroaki Oguro, Atsushi Nagai, Shuhei Yamaguchi

Affiliations

  1. Department of Neurology, Shimane Prefectural Central Hospital, Izumo, Japan.
  2. Department of Neurology, Shimane University, Izumo, Japan.
  3. Department of Laboratory Medicine, Faculty of Medicine, Shimane University, Izumo, Japan.

PMID: 25873927 PMCID: PMC4376920 DOI: 10.1159/000373916

Abstract

BACKGROUND: Chronic kidney disease (CKD) has been closely associated with stroke. Although a large number of studies reported the relationship between CKD and different types of asymptomatic brain lesions, few comprehensive analyses have been performed for all types of silent brain lesions.

METHODS: We performed a cross-sectional study involving 1,937 neurologically normal subjects (mean age 59.4 years). Mild CKD was defined as an estimated glomerular filtration rate between 30 and 60 ml/min/1.73 m(2) or positive proteinuria.

RESULTS: The prevalence of mild CKD was 8.7%. Univariate analysis revealed an association between CKD and all silent brain lesions, including silent brain infarction, periventricular hyperintensity, subcortical white matter lesion, and microbleeds, in addition to hypertension and diabetes mellitus after adjusting for age and sex. In binary logistic regression analysis, the presence of CKD was a significant risk factor for all types of silent brain lesions, independent of other risk factors.

CONCLUSIONS: These results suggest that mild CKD is independently associated with all types of silent brain lesions, even in neurologically normal subjects.

Keywords: Chronic kidney disease; Risk factors; Silent brain lesions; Small vessel disease

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