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Esfahanizadeh M, Mohebbi S, Dasht Bozorg B, et al. Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives. Iran J Pharm Res. 2015;14(2):417-27
Esfahanizadeh, M., Mohebbi, S., Dasht Bozorg, B., Amidi, S., Gudarzi, A., Ayatollahi, S. A., & Kobarfard, F. (2015). Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives. Iranian journal of pharmaceutical research : IJPR, 14(2), 417-27.
Esfahanizadeh, Marjan, et al. "Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives." Iranian journal of pharmaceutical research : IJPR vol. 14,2 (2015): 417-27.
Esfahanizadeh M, Mohebbi S, Dasht Bozorg B, Amidi S, Gudarzi A, Ayatollahi SA, Kobarfard F. Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives. Iran J Pharm Res. 2015;14(2):417-27. PMID: 25901148; PMCID: PMC4403057.
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Iran J Pharm Res. 2015;14(2):417-27.

Synthesis and Antiplatelet Aggregation Activity Evaluation of some 2-Aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine Derivatives.

Iranian journal of pharmaceutical research : IJPR

Marjan Esfahanizadeh, Shohreh Mohebbi, Behnam Dasht Bozorg, Salimeh Amidi, Ali Gudarzi, Seyed Abdolmajid Ayatollahi, Farzad Kobarfard

Affiliations

  1. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Central Research Laboratories, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  2. Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
  3. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  4. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  5. Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ; Central Research Laboratories, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

PMID: 25901148 PMCID: PMC4403057

Abstract

A series of novel 2-aminopyrimidine and 2-Substituted-4,6-diaminopyrimidine derivatives have been synthesized and their antiplatelet aggregation activities were assessed against ADP and arachidonic acid-induced platelet aggregation in human plasma using light transmission aggregometry. Among the tested derivatives, compounds Ia, Ib, IB and II16 exhibited the highest antiplatelet aggregation activity (36.75, 72.4, 62.5 and 80 µM). None of the compounds showed satisfactory activity against the aggregation induced by ADP but acceptable activities were observed against the aggregation induced by arachidonic acid. 2- aminopyrimidines were more active than 4,6- diaminopyrimidines in this respect.

Keywords: 2-Substituted-4; 2-aminopyrimidines; 6-diaminopyrimidines; Antiplatelet aggregation

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