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Eden G, Burkhardt O, Clajus C, et al. Daptomycin for a complicated urinary tract infection with vancomycin-resistant Enterococcus faecium in a renal transplant recipient. Clin Kidney J. 2012;5(4):350-1doi: 10.1093/ckj/sfs076.
Eden, G., Burkhardt, O., Clajus, C., & Kielstein, J. T. (2012). Daptomycin for a complicated urinary tract infection with vancomycin-resistant Enterococcus faecium in a renal transplant recipient. Clinical kidney journal, 5(4), 350-1. https://doi.org/10.1093/ckj/sfs076
Eden, Gabriele, et al. "Daptomycin for a complicated urinary tract infection with vancomycin-resistant Enterococcus faecium in a renal transplant recipient." Clinical kidney journal vol. 5,4 (2012): 350-1. doi: https://doi.org/10.1093/ckj/sfs076
Eden G, Burkhardt O, Clajus C, Kielstein JT. Daptomycin for a complicated urinary tract infection with vancomycin-resistant Enterococcus faecium in a renal transplant recipient. Clin Kidney J. 2012 Aug;5(4):350-1. doi: 10.1093/ckj/sfs076. PMID: 25874096; PMCID: PMC4393481.
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Clin Kidney J. 2012 Aug;5(4):350-1. doi: 10.1093/ckj/sfs076.

Daptomycin for a complicated urinary tract infection with vancomycin-resistant Enterococcus faecium in a renal transplant recipient.

Clinical kidney journal

Gabriele Eden, Olaf Burkhardt, Christian Clajus, Jan T Kielstein

Affiliations

  1. Department of Nephrology and Hypertension , Medical School Hannover , Hannover , Germany.
  2. Department of Pulmonary Medicine , Medical School Hannover , Hannover , Germany.

PMID: 25874096 PMCID: PMC4393481 DOI: 10.1093/ckj/sfs076

Abstract

There is an increasing prevalence of urinary tract infection (UTI) caused by multiresistant gram-negative enteric bacilli such as extended-spectrum beta-lactamase as well as Gram-positive enterococci whose vancomycin-resistance can be as high as 25%. We report on a 68-year-old Caucasian female with a UTI caused by a vancomycin-resistant Enterococcus faecium, only tested to be susceptible to gentamycin, linezolid and daptomycin. Within a day after administration of the bactericidal daptomycin clinical and laboratory signs of infection regressed and graft function recovered. Our case suggests that daptomycin might be an effective alternative for UTI caused by vancomycin-resistant enterococci.

Keywords: renal transplant recipient; urinary tract infection; vancomycin-resistant entorococci

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