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Gao P, Gao YJ, Liang HL. Effect of NF- κ B inhibitor PDTC on VEGF and endostatin expression of mice with Lewis lung cancer. Asian Pac J Trop Med. 2015;8(3):220-4doi: 10.1016/S1995-7645(14)60319-9.
Gao, P., Gao, Y. J., & Liang, H. L. (2015). Effect of NF- κ B inhibitor PDTC on VEGF and endostatin expression of mice with Lewis lung cancer. Asian Pacific journal of tropical medicine, 8(3), 220-4. https://doi.org/10.1016/S1995-7645(14)60319-9
Gao, Ping, et al. "Effect of NF- κ B inhibitor PDTC on VEGF and endostatin expression of mice with Lewis lung cancer." Asian Pacific journal of tropical medicine vol. 8,3 (2015): 220-4. doi: https://doi.org/10.1016/S1995-7645(14)60319-9
Gao P, Gao YJ, Liang HL. Effect of NF- κ B inhibitor PDTC on VEGF and endostatin expression of mice with Lewis lung cancer. Asian Pac J Trop Med. 2015 Mar;8(3):220-4. doi: 10.1016/S1995-7645(14)60319-9. PMID: 25902165.
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Asian Pac J Trop Med. 2015 Mar;8(3):220-4. doi: 10.1016/S1995-7645(14)60319-9.

Effect of NF- κ B inhibitor PDTC on VEGF and endostatin expression of mice with Lewis lung cancer.

Asian Pacific journal of tropical medicine

Ping Gao, Ya-Jie Gao, Hong-Lu Liang

Affiliations

  1. Oncology Department, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, China.
  2. Oncology Department, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, China. Electronic address: [email protected].
  3. Oncology Department, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, China. Electronic address: [email protected].

PMID: 25902165 DOI: 10.1016/S1995-7645(14)60319-9

Abstract

OBJECTIVE: To investigate the effects of NF- κ B inhibitor pyrrolidine dithiocarbamate hydrochloride (PDTC) on vascular endothelial growth factor (VEGF) and endostatin expression in mice with Lewis lung cance; and its mechanism.

METHODS: Mice survival rate and anti-tumor effects were observed in different concentrations of NF- κ B inhibitor PDTC after the Lewis lung cancer mice model was established. VEGF and endostatin expressions were detected by immunohistochemical assay.

RESULTS: Lewis lung cancer was be inhibited by 0.5 mg/kg, 1.5 mg/kg and 3.0 mg/kg of NF- κ B inhibitor PDTC (P<0.05). Microvessel density (MVD) in 0.5 mg/kg, 1.5 mg/kg and 3.0 mg/kg NF- κ B inhibitor PDTC groups were significantly lower than the control group (P<0.05). Immunohistochemical assay results showed that VEGF and endostatin expressions in the 0.5 mg/kg, 1.5 mg/kg and 3.0 mg/kg NF-κ B inhibitor PDTC groups were significantly lower than the control group (P<0.05). Western blot results also showed that NF- κ B inhibitor PDTC could inhibit VEGF and endostatin expressions in tumor tissues.

CONCLUSIONS: NF- κ B inhibitor PDTC can inhibit tumor formation and reduce tumor angiogenesis in mice with Lewis lung cancer; and its mechanism maybe associated to VEGF and endostatin down-regulation.

Copyright © 2015 Hainan Medical College. Production and hosting by Elsevier B.V. All rights reserved.

Keywords: Endostatin; Mice with Lewis lung cancer; PDTC; Pyrrolidine dithiocarbamate hydrochloride; Vascular density; Vascular endothelial growth factor

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