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Wang CD, Wang XR, Wang CY, et al. Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma. Asian Pac J Trop Med. 2015;8(3):249-52doi: 10.1016/S1995-7645(14)60326-6.
Wang, C. D., Wang, X. R., Wang, C. Y., Tang, Y. J., & Hao, M. W. (2015). Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma. Asian Pacific journal of tropical medicine, 8(3), 249-52. https://doi.org/10.1016/S1995-7645(14)60326-6
Wang, Cheng-De, et al. "Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma." Asian Pacific journal of tropical medicine vol. 8,3 (2015): 249-52. doi: https://doi.org/10.1016/S1995-7645(14)60326-6
Wang CD, Wang XR, Wang CY, Tang YJ, Hao MW. Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma. Asian Pac J Trop Med. 2015 Mar;8(3):249-52. doi: 10.1016/S1995-7645(14)60326-6. PMID: 25902172.
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Asian Pac J Trop Med. 2015 Mar;8(3):249-52. doi: 10.1016/S1995-7645(14)60326-6.

Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma.

Asian Pacific journal of tropical medicine

Cheng-De Wang, Xin-Rong Wang, Chao-Yang Wang, Yi-Jun Tang, Ming-Wen Hao

Affiliations

  1. Department of Thoracic Surgery, Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University, Yantai, Shandong Province, China.
  2. Department of Reproductive Medicine, Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University, Yantai, Shandong Province, China.
  3. Department of Thoracic Surgery, Yantai Yuhuangding Hospital affiliated to Medical College of Qingdao University, Yantai, Shandong Province, China. Electronic address: [email protected].

PMID: 25902172 DOI: 10.1016/S1995-7645(14)60326-6

Abstract

OBJECTIVE: To study the relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma.

METHODS: A total of 297 patients from July 2009 to May 2013 were chosen as objects. EGFR gene mutation were detected with fluorescence quantitative PCR. Relevance of EGFR gene mutation with clinical and pathological features was analyzed, and the prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was compared.

RESULTS: In 297 patients, 136 (45.79%) showed EGFR gene mutation. EGFR gene mutation had no significant relevance with age, gender, smoking history, family history of cancer and clinical stage (P>0.05); there was significant relevance between EGFR gene mutation and blood type, pathologic types, differentiation and diameter of cancer (P<0.05). The difference between prognosis of EGFR- mutant-patients and that of EGFR- wide type-patients was statistical significance (P<0.05).

CONCLUSIONS: EGFR gene mutation has significant relevance with pathological features, the prognosis of EGFR-mutant-patients is better than that of EGFR- wide type-patients.

Copyright © 2015 Hainan Medical College. Production and hosting by Elsevier B.V. All rights reserved.

Keywords: Epidermal growth factor receptor; Fluorescence quantitative PCR; Non–small–cell lung carcinoma; Pathological features; Prognosis

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