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Nam SY, Choi IJ, Ryu KH, et al. The effect of abdominal visceral fat, circulating inflammatory cytokines, and leptin levels on reflux esophagitis. J Neurogastroenterol Motil. 2015;21(2):247-54doi: 10.5056/jnm14114.
Nam, S. Y., Choi, I. J., Ryu, K. H., Park, B. J., Kim, Y. W., Kim, H. B., & Kim, J. S. (2015). The effect of abdominal visceral fat, circulating inflammatory cytokines, and leptin levels on reflux esophagitis. Journal of neurogastroenterology and motility, 21(2), 247-54. https://doi.org/10.5056/jnm14114
Nam, Su Youn, et al. "The effect of abdominal visceral fat, circulating inflammatory cytokines, and leptin levels on reflux esophagitis." Journal of neurogastroenterology and motility vol. 21,2 (2015): 247-54. doi: https://doi.org/10.5056/jnm14114
Nam SY, Choi IJ, Ryu KH, Park BJ, Kim YW, Kim HB, Kim JS. The effect of abdominal visceral fat, circulating inflammatory cytokines, and leptin levels on reflux esophagitis. J Neurogastroenterol Motil. 2015 Mar 30;21(2):247-54. doi: 10.5056/jnm14114. PMID: 25843077; PMCID: PMC4398239.
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J Neurogastroenterol Motil. 2015 Mar 30;21(2):247-54. doi: 10.5056/jnm14114.

The effect of abdominal visceral fat, circulating inflammatory cytokines, and leptin levels on reflux esophagitis.

Journal of neurogastroenterology and motility

Su Youn Nam, Il Ju Choi, Kum Hei Ryu, Bum Joon Park, Young-Woo Kim, Hyun Beom Kim, Jeong Seon Kim

Affiliations

  1. Center for Cancer Prevention and Detection, National Cancer Center, Goyang, Gyeonggi-do, Korea.
  2. Center for Gastric Cancer, Kyungpook National University Hospital, Daegu, Korea.
  3. Center for Gastric Cancer, Division of Cancer Epidemiology and Prevention, National Cancer Center, Goyang, Gyeonggi-do, Korea.
  4. Department of Radiology, Division of Cancer Epidemiology and Prevention, National Cancer Center, Goyang, Gyeonggi-do, Korea.
  5. Department of Molecular Epidemiology Branch, Division of Cancer Epidemiology and Prevention, National Cancer Center, Goyang, Gyeonggi-do, Korea.

PMID: 25843077 PMCID: PMC4398239 DOI: 10.5056/jnm14114

Abstract

BACKGROUND/AIMS: Although adipocytes secrete inflammatory cytokines and adipokines, their role in reflux esophagitis is controversial. We investigated the association between visceral fat and inflammatory cytokines or adipokines in reflux esophagitis.

METHODS: Abdominal visceral fat and cytokines were measured in 66 individuals with reflux esophagitis and 66 age- and sex-matched controls. The mean values for visceral fat and cytokines were compared in cases and controls. Second, correlations between visceral fat and inflammatory cytokines were measured. Finally, multiple logistic regression models for odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the effects of visceral fat and cytokines on reflux esophagitis.

RESULTS: Visceral fat, leptin, interleukin (IL)-6, and IL-1β were higher in reflux esophagitis compared to controls. Visceral fat showed a strong positive correlation with IL-6 (r = 0.523, P < 0.001), IL-8 (r = 0.395, P < 0.001), and IL-1β (r = 0.557, P < 0.001), and a negative correlation with adiponectin (r = -0.466, P < 0.001). With adjusted analysis, visceral fat/100 (OR, 4.32; 95% CI, 2.18-8.58; P < 0.001) and leptin (OR, 1.36; 95% CI, 1.10-1.69; P = 0.005) independently increased the risk of reflux esophagitis, but the effects of other cytokines were abolished.

CONCLUSIONS: Visceral fat may increase the risk of reflux esophagitis by increasing the levels of inflammatory cytokines. Leptin showed a positive association with reflux esophagitis that was independent of visceral fat.

Keywords: Adipokines; Cytokines; Esophagitis

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