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Yan X, Marini J, Mulligan R, et al. Slit-surface electrospinning: a novel process developed for high-throughput fabrication of core-sheath fibers. PLoS One. 2015;10(5):e0125407doi: 10.1371/journal.pone.0125407.
Yan, X., Marini, J., Mulligan, R., Deleault, A., Sharma, U., Brenner, M. P., Rutledge, G. C., Freyman, T., & Pham, Q. P. (2015). Slit-surface electrospinning: a novel process developed for high-throughput fabrication of core-sheath fibers. PloS one, 10(5), e0125407. https://doi.org/10.1371/journal.pone.0125407
Yan, Xuri, et al. "Slit-surface electrospinning: a novel process developed for high-throughput fabrication of core-sheath fibers." PloS one vol. 10,5 (2015): e0125407. doi: https://doi.org/10.1371/journal.pone.0125407
Yan X, Marini J, Mulligan R, Deleault A, Sharma U, Brenner MP, Rutledge GC, Freyman T, Pham QP. Slit-surface electrospinning: a novel process developed for high-throughput fabrication of core-sheath fibers. PLoS One. 2015 May 04;10(5):e0125407. doi: 10.1371/journal.pone.0125407. eCollection 2015. PMID: 25938411; PMCID: PMC4418707.
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PLoS One. 2015 May 04;10(5):e0125407. doi: 10.1371/journal.pone.0125407. eCollection 2015.

Slit-surface electrospinning: a novel process developed for high-throughput fabrication of core-sheath fibers.

PloS one

Xuri Yan, John Marini, Robert Mulligan, Abby Deleault, Upma Sharma, Michael P Brenner, Gregory C Rutledge, Toby Freyman, Quynh P Pham

Affiliations

  1. Arsenal Medical, Inc., Watertown, Massachusetts, United States of America.
  2. School of Engineering and Applied Science, Harvard University, Cambridge, Massachusetts, United States of America.
  3. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.

PMID: 25938411 PMCID: PMC4418707 DOI: 10.1371/journal.pone.0125407

Abstract

In this work, we report on the development of slit-surface electrospinning--a process that co-localizes two solutions along a slit surface to spontaneously emit multiple core-sheath cone-jets at rates of up to 1 L/h. To the best of our knowledge, this is the first time that production of electrospun core-sheath fibers has been scaled to this magnitude. Fibers produced in this study were defect-free (i.e. non-beaded) and core-sheath geometry was visually confirmed under scanning electron microscopy. The versatility of our system was demonstrated by fabrication of (1) fibers encapsulating a drug, (2) bicomponent fibers, (3) hollow fibers, and (4) fibers from a polymer that is not normally electrospinnable. Additionally, we demonstrate control of the process by modulating parameters such as flow rate, solution viscosity, and fixture design. The technological achievements demonstrated in this work significantly advance core-sheath electrospinning towards commercial and manufacturing viability.

References

  1. Phys Rev Lett. 2002 Feb 18;88(7):074501 - PubMed
  2. Science. 2001 Apr 13;292(5515):265-7 - PubMed
  3. J Biomed Mater Res A. 2009 Sep 15;90(4):1243-51 - PubMed
  4. J Biomater Sci Polym Ed. 2011;22(1-3):165-77 - PubMed
  5. Macromol Biosci. 2008 Sep 9;8(9):803-6 - PubMed
  6. Nanotechnology. 2011 Aug 26;22(34):345301 - PubMed
  7. Langmuir. 2009 Aug 18;25(16):9454-62 - PubMed
  8. Macromol Biosci. 2011 Nov 10;11(11):1526-36 - PubMed
  9. Biomacromolecules. 2012 Apr 9;13(4):952-62 - PubMed
  10. Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Aug;70(2 Pt 2):026302 - PubMed

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