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Campolina SS, Araujo MS, Rezende TM, et al. Effective anthelmintic therapy of residents living in endemic area of high prevalence for Hookworm and Schistosoma mansoni infections enhances the levels of allergy risk factor anti-Der p1 IgE. Results Immunol. 2013;5:6-12doi: 10.1016/j.rinim.2013.11.001.
Campolina, S. S., Araujo, M. S., Rezende, T. M., Matoso, L., Quites, H. F., Teixeira-Carvalho, A., Martins-Filho, O. A., Gazzinelli, A., & Correa-Oliveira, R. (2015). Effective anthelmintic therapy of residents living in endemic area of high prevalence for Hookworm and Schistosoma mansoni infections enhances the levels of allergy risk factor anti-Der p1 IgE. Results in immunology, 56-12. https://doi.org/10.1016/j.rinim.2013.11.001
Campolina, Sabrina S, et al. "Effective anthelmintic therapy of residents living in endemic area of high prevalence for Hookworm and Schistosoma mansoni infections enhances the levels of allergy risk factor anti-Der p1 IgE." Results in immunology vol. 5 (2015): 6-12. doi: https://doi.org/10.1016/j.rinim.2013.11.001
Campolina SS, Araujo MS, Rezende TM, Matoso L, Quites HF, Teixeira-Carvalho A, Martins-Filho OA, Gazzinelli A, Correa-Oliveira R. Effective anthelmintic therapy of residents living in endemic area of high prevalence for Hookworm and Schistosoma mansoni infections enhances the levels of allergy risk factor anti-Der p1 IgE. Results Immunol. 2013 Dec 05;5:6-12. doi: 10.1016/j.rinim.2013.11.001. eCollection 2015. PMID: 25905031; PMCID: PMC4404415.
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Results Immunol. 2013 Dec 05;5:6-12. doi: 10.1016/j.rinim.2013.11.001. eCollection 2015.

Effective anthelmintic therapy of residents living in endemic area of high prevalence for Hookworm and Schistosoma mansoni infections enhances the levels of allergy risk factor anti-Der p1 IgE.

Results in immunology

Sabrina S Campolina, Marcio S S Araujo, Tércia M R L Rezende, Leonardo Matoso, Humberto F O Quites, Andréa Teixeira-Carvalho, Olindo A Martins-Filho, Andrea Gazzinelli, Rodrigo Correa-Oliveira

Affiliations

  1. Laboratório de Imunologia Celular e Molecular, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
  2. Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil.
  3. Faculdade de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  4. Faculdade de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil ; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Belo Horizonte, Minas Gerais, Brazil.
  5. Laboratório de Imunologia Celular e Molecular, Centro de Pesquisas René Rachou FIOCRUZ-Minas, Belo Horizonte, Minas Gerais, Brazil ; Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais (INCT-DT), Belo Horizonte, Minas Gerais, Brazil.

PMID: 25905031 PMCID: PMC4404415 DOI: 10.1016/j.rinim.2013.11.001

Abstract

In this work were investigated the relationship between Hookworm/Schistosoma mansoni infections and allergy related risk factors in two endemic areas with distinct prevalence of infections and co-infection. The intensity of infections, eosinophilia, allergy risk factors, infections status and anti-Der p1 IgE levels before and 2 years (population 1) and 3 years (population 2) after anthelmintic treatment, were evaluated. It was observed that the population with lower prevalence and intensity of infection (population 2) had lower eosinophils counts (>600/mm(3)) and higher animal contact than the population with higher parasites intensity (population 1). After anthelmintic treatment the intensity of S. mansoni single infection decreased, but no changes were observed in Hookworm and co-infected individuals. The anthelmintic treatment also enhanced anti-Der p1 IgE optical density in ELISA on the subgroups that became negative for helminth infection regardless of their previous infection condition in population 1. Facing that, we evaluated the anti-Der p1 IgE reactivity index, and the ratio (after/before treatment) was significantly higher in patients co-infected before treatment. On the other hand, no association between anti-Der p1 IgE reactivity index and the intensity of infections were observed. In conclusion, effective anthelmintic therapy of subjects from endemic areas with high prevalence of Hookworm and S. mansoni infections enhances anti-Der p1 IgE levels.

Keywords: Allergic disorders; Allergy risk factors; Anti-Der p1 IgE

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