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Yıldırım Ş, Topaloğlu N, Tekin M, et al. Protective role of Proanthocyanidin in experimental ovarian torsion. Med J Islam Repub Iran. 2015;29:185
Yıldırım, �. �., Topaloğlu, N., Tekin, M., Küçük, A., Erdem, H., Erbaş, M., & Yıldırım, A. (2015). Protective role of Proanthocyanidin in experimental ovarian torsion. Medical journal of the Islamic Republic of Iran, 29185.
Yıldırım, Şule, et al. "Protective role of Proanthocyanidin in experimental ovarian torsion." Medical journal of the Islamic Republic of Iran vol. 29 (2015): 185.
Yıldırım Ş, Topaloğlu N, Tekin M, Küçük A, Erdem H, Erbaş M, Yıldırım A. Protective role of Proanthocyanidin in experimental ovarian torsion. Med J Islam Repub Iran. 2015 Feb 23;29:185. eCollection 2015. PMID: 26034738; PMCID: PMC4431445.
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Med J Islam Repub Iran. 2015 Feb 23;29:185. eCollection 2015.

Protective role of Proanthocyanidin in experimental ovarian torsion.

Medical journal of the Islamic Republic of Iran

Şule Yıldırım, Naci Topaloğlu, Mustafa Tekin, Adem Küçük, Havva Erdem, Mesut Erbaş, Ahmet Yıldırım

Affiliations

  1. Assistant Professor, Department of Pediatrics, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. [email protected].
  2. Assistant Professor, Department of Pediatrics, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. [email protected].
  3. Assistant Professor, Department of Pediatrics, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. [email protected].
  4. MD, Department of Pediatric Surgery, Düzce Atatürk State Hospital, Düzce, Turkey. [email protected].
  5. Associate Professor, Department of Pathology, Düzce University Medical Faculty, Düzce, Turkey. [email protected].
  6. Assistant Professor, Department of Anesthesiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. [email protected].
  7. Assistant Professor, Department of Emergency Medicine, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey. [email protected].

PMID: 26034738 PMCID: PMC4431445

Abstract

BACKGROUND: Proanthocyanidin is a potent bioactive antioxidant naturally occurring in grape seed and acts as reactive oxygen species (ROS) scavenger. The aim of this study was to investigate the effects of proanthocyanidinin in experimental ovarian torsion injury.

METHODS: Twenty four rats were randomly divided into three groups (n=8). Group 1: the laparotomy group, group 2: ovarian torsion group, and group 3: intervention group administered proanthocyanidinin of 50 mg/kg before bilateral ovarian ischemia and reperfusion. Histologic examination and scoring was done at the end of the experiment. Statistical analyses were performed using the SPSS v. 19.

RESULTS: Ovarian histopathologic findings of all three groups were significantly different in terms of hemorrhage (p<0.001), edema (p=0.001) and vascular dilatation (p< 0.001). Pathologic changes induced by I/R were reduced in ovaries of rats administered proanthocyanidin, in particular, hemorrhage, edema and vascular dilatation.

CONCLUSION: Proanthocyanidin, known as free radical scavenger and antioxidant, is protective against tissue damage induced by ischemia and/or ischemia/reperfusion in rat ovaries.

Keywords: Fertility; Ischemia Reperfusion; Ovarian torsion; Proanthocyanidinin

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