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Amoakwa K, Martinson NA, Moulton LH, et al. Risk factors for developing active tuberculosis after the treatment of latent tuberculosis in adults infected with human immunodeficiency virus. Open Forum Infect Dis. 2015;2(1):ofu120doi: 10.1093/ofid/ofu120.
Amoakwa, K., Martinson, N. A., Moulton, L. H., Barnes, G. L., Msandiwa, R., & Chaisson, R. E. (2015). Risk factors for developing active tuberculosis after the treatment of latent tuberculosis in adults infected with human immunodeficiency virus. Open forum infectious diseases, 2(1), ofu120. https://doi.org/10.1093/ofid/ofu120
Amoakwa, Kojo, et al. "Risk factors for developing active tuberculosis after the treatment of latent tuberculosis in adults infected with human immunodeficiency virus." Open forum infectious diseases vol. 2,1 (2015): ofu120. doi: https://doi.org/10.1093/ofid/ofu120
Amoakwa K, Martinson NA, Moulton LH, Barnes GL, Msandiwa R, Chaisson RE. Risk factors for developing active tuberculosis after the treatment of latent tuberculosis in adults infected with human immunodeficiency virus. Open Forum Infect Dis. 2015 Jan 20;2(1):ofu120. doi: 10.1093/ofid/ofu120. eCollection 2015 Jan. PMID: 26034751; PMCID: PMC4438881.
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Open Forum Infect Dis. 2015 Jan 20;2(1):ofu120. doi: 10.1093/ofid/ofu120. eCollection 2015 Jan.

Risk factors for developing active tuberculosis after the treatment of latent tuberculosis in adults infected with human immunodeficiency virus.

Open forum infectious diseases

Kojo Amoakwa, Neil A Martinson, Lawrence H Moulton, Grace L Barnes, Reginah Msandiwa, Richard E Chaisson

Affiliations

  1. Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland.
  2. Perinatal HIV Research Unit , University of Witwatersrand , Johannesburg , South Africa ; Johns Hopkins University Center for Tuberculosis Research , Baltimore, Maryland.
  3. Johns Hopkins University Center for Tuberculosis Research , Baltimore, Maryland.
  4. Perinatal HIV Research Unit , University of Witwatersrand , Johannesburg , South Africa.
  5. Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland ; Johns Hopkins University Center for Tuberculosis Research , Baltimore, Maryland.

PMID: 26034751 PMCID: PMC4438881 DOI: 10.1093/ofid/ofu120

Abstract

Tuberculosis is the leading cause of death among adults infected with human immunodeficiency virus (HIV), and rates of tuberculosis remain high even after preventive therapy. Among 908 HIV-infected adults in a trial of preventive treatment, we found self-reported alcohol consumption, low baseline CD4 count, high baseline viral load, and tuberculin skin test size >15 mm as independent risk factors for incident tuberculosis.

Keywords: HIV-infected adults; baseline; latent tuberculosis; preventive therapy; risk

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