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Boryczka G, Waluga M, Budzyńska A, et al. Severe viral oesophagitis, pharyngitis, and stomatitis as antecedents of ileocecal Crohn's disease. Prz Gastroenterol. 2015;10(1):47-50doi: 10.5114/pg.2014.47495.
Boryczka, G., Waluga, M., Budzyńska, A., Kajor, M., & Hartleb, M. (2015). Severe viral oesophagitis, pharyngitis, and stomatitis as antecedents of ileocecal Crohn's disease. Przeglad gastroenterologiczny, 10(1), 47-50. https://doi.org/10.5114/pg.2014.47495
Boryczka, Grzegorz, et al. "Severe viral oesophagitis, pharyngitis, and stomatitis as antecedents of ileocecal Crohn's disease." Przeglad gastroenterologiczny vol. 10,1 (2015): 47-50. doi: https://doi.org/10.5114/pg.2014.47495
Boryczka G, Waluga M, Budzyńska A, Kajor M, Hartleb M. Severe viral oesophagitis, pharyngitis, and stomatitis as antecedents of ileocecal Crohn's disease. Prz Gastroenterol. 2015;10(1):47-50. doi: 10.5114/pg.2014.47495. Epub 2015 Feb 06. PMID: 25960815; PMCID: PMC4411404.
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Prz Gastroenterol. 2015;10(1):47-50. doi: 10.5114/pg.2014.47495. Epub 2015 Feb 06.

Severe viral oesophagitis, pharyngitis, and stomatitis as antecedents of ileocecal Crohn's disease.

Przeglad gastroenterologiczny

Grzegorz Boryczka, Marek Waluga, Agnieszka Budzyńska, Maciej Kajor, Marek Hartleb

Affiliations

  1. Department of Gastroenterology and Hepatology, Medical University of Silesia, Katowice, Poland.
  2. Department of Pathomorphology, Medical University of Silesia, Katowice, Poland.

PMID: 25960815 PMCID: PMC4411404 DOI: 10.5114/pg.2014.47495

Abstract

We present a 22-year-old male who developed a severe erosive oesophagitis extending to the pharynx and oral cavity without obvious risk factors. Endoscopic image suggested viral aetiology that could not be confirmed by routine serological diagnostics of infections with cytomegalovirus, Epstein-Barr virus, and Herpes simplex virus. The histopathological evaluation also gave no definite clues to the aetiology of the inflammation. Treatment with acyclovir was ineffective, but gancyclovir therapy caused spectacular clinical improvement and healing of erosions. Two months later the patient presented febrile diarrhoea that was a symptom of ileocecal Crohn's disease proven by endoscopy, enterography, and histopathology. It is the first report of severe viral oesophagitis preceding clinical manifestation of Crohn's disease. This observation warrants further study towards the viral aetiology of oral, pharyngeal, and oesophageal erosions, frequently associated with Crohn's disease.

Keywords: Crohn's disease; erosive oesophagitis; viral oesophagitis

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