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Mediterr J Hematol Infect Dis. 2015 Apr 20;7(1):e2015026. doi: 10.4084/MJHID.2015.026. eCollection 2015.

A case of rupioid syphilis masquerading as aggressive cutaneous lymphoma.

Mediterranean journal of hematology and infectious diseases

Jonathan Braue, Thomas Hagele, Abraham Tareq Yacoub, Suganya Mannivanan, Lubomir Sokol, Frank Glass, John N Greene

Affiliations

  1. University of South Florida Morsani College of Medicine, 12901 Bruce B. Down Blvd, Tampa, Florida 33612-4742.
  2. University of South Florida Morsani College of Medicine, Department of Dermatology and Cutaneous Surgery, 12901 Bruce B. Down Blvd, Tampa, Florida 33612-4742.
  3. Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612-9497.
  4. University of South Florida, Morsani College of Medicine, Division of Infectious Disease and International Medicine, 1 Tampa General Circle, G323, Tampa, Florida 33612-9497.
  5. Moffitt Cancer Center, Department of Cutaneous Oncology, 12902 Magnolia Drive, Tampa, Florida 33612-9497.
  6. Moffitt Cancer Center, University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, Florida 33612-9497.

PMID: 25960854 PMCID: PMC4418386 DOI: 10.4084/MJHID.2015.026

Abstract

Secondary syphilis has been known since the late 19th century as the great imitator; however, some experts now regard cutaneous lymphoma as the great imitator of skin disease. Either disease, at times an equally fastidious diagnosis, has reported to mimic each other even. It is thus vital to consider these possibilities when presented with a patient demonstrating peculiar skin lesions. No other manifestation of secondary syphilis may pose such quandary as a rare case of rupioid syphilis impersonating cutaneous lymphoma. We present such a case, of a 36-year-old HIV positive male, misdiagnosed with aggressive cutaneous lymphoma, actually exhibiting rupioid syphilis thought secondary to immune reconstitution inflammatory syndrome (IRIS).

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