Can J Kidney Health Dis. 2014 Sep 02;1:19. doi: 10.1186/s40697-014-0019-4. eCollection 2014.
Fluid balance, change in serum creatinine and urine output as markers of acute kidney injury post cardiac surgery: an observational study.
Canadian journal of kidney health and disease
Katrina Chau, Travis Schisler, Lee Er, Dharmvir Jaswal, Christopher Cheung, Amanda Israel, John Bowering, Adeera Levin
Affiliations
Affiliations
- Division of Nephrology, Faculty of Medicine, The University of British Columbia, St Paul's Hospital, 1081 Burrard St, Vancouver, BC V6Z1Y6 Canada.
- Department of Anesthesiology, Pharmacology and Therapeutics, The University of British Columbia, St Paul's Hospital, 1081 Burrard St, Vancouver, BC V6Z1Y6 Canada.
- Faculty of Medicine, The University of British Columbia, St Paul's Hospital, 1081 Burrard St, Vancouver, BC V6Z1Y6 Canada.
PMID: 25960885
PMCID: PMC4424577 DOI: 10.1186/s40697-014-0019-4
Abstract
BACKGROUND: Acute kidney injury (AKI) is defined as oliguria or rise in serum creatinine but oliguria alone as a diagnostic criterion may over-diagnose AKI.
OBJECTIVES: Given the association between fluid overload and AKI, we aimed to determine if positive fluid balance can complement the known parameters in assessing outcomes of AKI.
DESIGN: Prospective observational study.
SETTING: Teaching hospital in Vancouver, Canada.
PATIENTS: 111 consecutive patients undergoing elective cardiac surgery from January to April 2012.
MEASUREMENTS: Outcomes of cardiac surgery intensive care unit (CSICU) and hospital length of stay (LOS) in relation to fluid balance, urine output and serum creatinine.
METHODS: All fluid input and output was recorded for 72 hours post-operatively. Positive fluid balance was defined as >6.5 cc/kg. Daily serum creatinine and hourly urine output were recorded and patients were defined as having AKI according to the AKIN criteria.
RESULTS: Of the patients who were oliguric, those with fluid overload trended towards longer LOS than those without fluid overload [CSICU LOS: 62 and 39 hours (unadjusted p-value 0.02, adjusted p-value 0.58); hospital LOS: 13 and 9 days (unadjusted p-value: 0.05, adjusted p-value: 0.16)]. Patients with oliguria who were fluid overloaded had similar LOS to patients with overt AKI (change in serum creatinine ≥ 26.5 µmol/L), [CSICU LOS: 62 and 69 hours (adjusted p value: 0.32) and hospital LOS: 13 and 14 days (adjusted p value: 0.19)]. Patients with oliguria regardless of fluid balance had longer CSICU LOS (adjusted p value: 0.001) and patients who were fluid overloaded in the absence of AKI had longer hospital LOS (adjusted p value: 0.02).
LIMITATIONS: Single centre, small sample, LOS as outcome.
CONCLUSIONS: Oliguria and positive fluid balance is associated with a trend towards longer LOS as compared to oliguria alone. Fluid balance may therefore be a useful marker of AKI, in addition to urine output and serum creatinine.
Keywords: Acute kidney injury; Cardiac surgery; Diagnosis; Fluid resuscitation
References
- Crit Care. 2013 Jan 17;17(1):R7 - PubMed
- Crit Care. 2008;12(3):R74 - PubMed
- J Cardiothorac Vasc Anesth. 2013 Dec;27(6):1145-52 - PubMed
- Crit Care. 2010;14(3):R82 - PubMed
- Am J Kidney Dis. 2011 Feb;57(2):228-34 - PubMed
- Crit Care. 2007;11(2):R31 - PubMed
- Crit Care. 2011 Jul 19;15(4):R172 - PubMed
- J Am Soc Nephrol. 2010 Feb;21(2):345-52 - PubMed
- J Am Soc Nephrol. 2009 Mar;20(3):672-9 - PubMed
- J Am Soc Nephrol. 2005 Nov;16(11):3365-70 - PubMed
- Clin J Am Soc Nephrol. 2010 Apr;5(4):733-9 - PubMed
- Crit Care. 2013 Jun 20;17(3):R112 - PubMed
- Am J Epidemiol. 1987 Feb;125(2):319-23 - PubMed
- Nat Rev Nephrol. 2013 Oct;9(10):568-70 - PubMed
- Ann Intensive Care. 2011 Mar 21;1(1):2 - PubMed
- J Am Coll Surg. 2009 May;208(5):725-35; discussion 735-7 - PubMed
- Blood Purif. 2010;29(4):331-8 - PubMed
- Kidney Int. 2009 Aug;76(4):422-7 - PubMed
- Kidney Int. 2011 Oct;80(7):760-7 - PubMed
- Crit Care. 2013 Jan 24;17(1):R14 - PubMed
- Crit Care Med. 2011 Dec;39(12):2659-64 - PubMed
- Crit Care. 2011;15(5):R226 - PubMed
- Crit Care Med. 2011 Dec;39(12):2665-71 - PubMed
- Nephrol Dial Transplant. 2012 Mar;27(3):956-61 - PubMed
Publication Types