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Keshvari M, Alavian SM, Sharafi H. Comparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients. Jundishapur J Microbiol. 2015;8(3):e21444doi: 10.5812/jjm.21444.
Keshvari, M., Alavian, S. M., & Sharafi, H. (2015). Comparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients. Jundishapur journal of microbiology, 8(3), e21444. https://doi.org/10.5812/jjm.21444
Keshvari, Maryam, et al. "Comparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients." Jundishapur journal of microbiology vol. 8,3 (2015): e21444. doi: https://doi.org/10.5812/jjm.21444
Keshvari M, Alavian SM, Sharafi H. Comparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients. Jundishapur J Microbiol. 2015 Jan 14;8(3):e21444. doi: 10.5812/jjm.21444. eCollection 2015 Mar. PMID: 25973160; PMCID: PMC4426187.
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Jundishapur J Microbiol. 2015 Jan 14;8(3):e21444. doi: 10.5812/jjm.21444. eCollection 2015 Mar.

Comparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients.

Jundishapur journal of microbiology

Maryam Keshvari, Seyed Moayed Alavian, Heidar Sharafi

Affiliations

  1. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, IR Iran ; Middle East Liver Diseases (MELD) Center, Tehran, IR Iran ; Iran Hepatitis Network, Tehran, IR Iran.
  2. Middle East Liver Diseases (MELD) Center, Tehran, IR Iran ; Iran Hepatitis Network, Tehran, IR Iran.

PMID: 25973160 PMCID: PMC4426187 DOI: 10.5812/jjm.21444

Abstract

BACKGROUND: Chronic hepatitis B consists of different clinical phases. Laboratory and histological assessments can help differentiate the clinical phases of this disease and thus lead to better management.

OBJECTIVES: This study was conducted to determine laboratory and histological characteristics of HBeAg-negative and HBeAg-positive chronic hepatitis B patients.

PATIENTS AND METHODS: In this study, we evaluated 151 treatment naive chronic hepatitis B patients and grouped them according to their HBeAg status. Serum hepatitis B virus (HBV) DNA and HBsAg levels were measured, and liver function tests, and liver biopsy were performed for the study population.

RESULTS: There was a significant difference in age, and HBV DNA and HBsAg levels between HBeAg-negative and HBeAg-positive groups yet there was no statistically significant difference in sex, liver function tests, grading and staging of liver biopsy between the groups. Hepatitis B virus DNA and HBsAg levels were correlated in both HBeAg-negative and HBeAg-positive chronic hepatitis B patients.

CONCLUSIONS: We concluded that chronic hepatitis B patients had different HBV DNA and HBsAg levels according to their HBeAg status.

Keywords: HBeAg; HBsAg; Hepatitis B

References

  1. Mater Sociomed. 2014 Apr;26(2):129-33 - PubMed
  2. Hepatology. 2007 Feb;45(2):507-39 - PubMed
  3. Hepat Mon. 2011 May;11(5):342-5 - PubMed
  4. Ann Hepatol. 2012 Jul-Aug;11(4):464-70 - PubMed
  5. World J Gastroenterol. 2003 Oct;9(10):2322-4 - PubMed
  6. J Hepatol. 2010 Apr;52(4):508-13 - PubMed
  7. Can J Infect Dis Med Microbiol. 2005 Mar;16(2):65-72 - PubMed
  8. J Hepatol. 2010 Apr;52(4):514-22 - PubMed
  9. Semin Liver Dis. 2005;25 Suppl 1:3-8 - PubMed
  10. World J Gastroenterol. 2014 Jul 21;20(27):9178-84 - PubMed
  11. Hepatology. 2009 Sep;50(3):661-2 - PubMed
  12. Hepatology. 1988 Sep-Oct;8(5):1130-3 - PubMed
  13. J Hepatol. 2007 Oct;47(4):598-607 - PubMed
  14. Ann Intern Med. 1981 Jun;94(6):744-8 - PubMed
  15. Indian J Gastroenterol. 2014 Mar;33(2):131-5 - PubMed
  16. Hepatology. 2002 Dec;36(6):1408-15 - PubMed
  17. J Gastroenterol Hepatol. 2002 Jun;17(6):671-6 - PubMed
  18. World J Gastroenterol. 2008 Sep 21;14(35):5448-53 - PubMed
  19. Antivir Ther. 2010;15(8):1133-9 - PubMed
  20. Hepatology. 2010 Oct;52(4):1232-41 - PubMed
  21. Zhonghua Nei Ke Za Zhi. 2005 Sep;44(9):648-51 - PubMed
  22. Zhonghua Gan Zang Bing Za Zhi. 2012 May;20(5):348-52 - PubMed
  23. J Med Virol. 2011 Jun;83(6):948-52 - PubMed
  24. Aliment Pharmacol Ther. 2005 Aug 15;22(4):301-7 - PubMed

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