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Nunomura S, Makishima M, Ra C. Liver X receptors and immune regulation. Biomol Concepts. 2010;1(5):381-7doi: 10.1515/bmc.2010.030.
Nunomura, S., Makishima, M., & Ra, C. (2010). Liver X receptors and immune regulation. Biomolecular concepts, 1(5), 381-7. https://doi.org/10.1515/bmc.2010.030
Nunomura, Satoshi, et al. "Liver X receptors and immune regulation." Biomolecular concepts vol. 1,5 (2010): 381-7. doi: https://doi.org/10.1515/bmc.2010.030
Nunomura S, Makishima M, Ra C. Liver X receptors and immune regulation. Biomol Concepts. 2010 Dec 01;1(5):381-7. doi: 10.1515/bmc.2010.030. PMID: 25962011.
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Biomol Concepts. 2010 Dec 01;1(5):381-7. doi: 10.1515/bmc.2010.030.

Liver X receptors and immune regulation.

Biomolecular concepts

Satoshi Nunomura, Makoto Makishima, Chisei Ra

PMID: 25962011 DOI: 10.1515/bmc.2010.030

Abstract

Recent studies suggest that homeostasis of lipid metabolism is crucial for the function of various immune cells. Oxygenated derivatives of cholesterol (oxysterols) are well-known regulators of lipid metabolism and have diverse functions, such as inhibition of cholesterol synthesis, efflux of intracellular cholesterol, synthesis of cholesterol esters, and activation of liver X receptors (LXRs). In this review, we introduce novel roles of the oxysterol receptors LXRs in the immune system, including regulation of inflammatory responses, T cell expansion, immunoglobulin production, and antitumor responses. We also discuss lipid-mediated signaling as a potential target for treatment of immune diseases.

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