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Husso T, Turunen MP, Parker N, et al. Epigenetherapy, a new concept. Biomol Concepts. 2011;2(3):127-34doi: 10.1515/bmc.2011.012.
Husso, T., Turunen, M. P., Parker, N., & Ylä-Herttuala, S. (2011). Epigenetherapy, a new concept. Biomolecular concepts, 2(3), 127-34. https://doi.org/10.1515/bmc.2011.012
Husso, Tiia, et al. "Epigenetherapy, a new concept." Biomolecular concepts vol. 2,3 (2011): 127-34. doi: https://doi.org/10.1515/bmc.2011.012
Husso T, Turunen MP, Parker N, Ylä-Herttuala S. Epigenetherapy, a new concept. Biomol Concepts. 2011 Jun 01;2(3):127-34. doi: 10.1515/bmc.2011.012. PMID: 25962024.
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Biomol Concepts. 2011 Jun 01;2(3):127-34. doi: 10.1515/bmc.2011.012.

Epigenetherapy, a new concept.

Biomolecular concepts

Tiia Husso, Mikko P Turunen, Nigel Parker, Seppo Ylä-Herttuala

PMID: 25962024 DOI: 10.1515/bmc.2011.012

Abstract

Small RNAs have been shown to regulate gene transcription by interacting with the promoter region and modifying the histone code. The exact mechanism of function is still unclear but the feasibility to activate or repress endogenous gene expression with small RNA molecules has already been demonstrated in vitro and in vivo. In traditional gene therapy non-mutated or otherwise useful genes are inserted into patient's cells to treat a disease. In epigenetherapy the action of small RNAs is utilized by delivering only the small RNAs to patient's cells where they then regulate gene expression by epigenetic mechanisms. This method could be widely useful not only for basic research but also for clinical applications of small RNAs.

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