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J Virus Erad. 2015 Jan;1(1):30-37.

Cervical cytological abnormalities and HPV infection in perinatally HIV-infected adolescents.

Journal of virus eradication

J Ananworanich, W Prasitsuebsai, S J Kerr, R Hansudewechakul, N Teeratakulpisarn, K Saisawat, R Ramautarsing, J Achalapong, K Pussadee, S Keadpudsa, T Mackay, T Pankam, P Rodbamrung, W Petdachai, K Chokephaibulkit, A H Sohn, N Phanuphak

Affiliations

  1. HIV Netherland Australia Thailand Research Collaboration (HIV-NAT), Bangkok, Thailand.
  2. Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  3. SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  4. Kirby Institute of Infection and Immunity in Society, University of New South Wales, Sydney, Australia.
  5. Chiangrai Prachanukroh Hospital, Chiangrai, Thailand.
  6. Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam Institute for Global Health and Development (AIGHD), Amsterdam, the Netherlands.
  7. Petchburi Hospital, Petchburi, Thailand.
  8. Faculty of Medicine, Siriraj Hosptial, Mahidol University, Bangkok, Thailand.
  9. TREAT Asia/amfAR - The Foundation for AIDS Research, Bangkok, Thailand.

PMID: 26005716 PMCID: PMC4439002

Abstract

BACKGROUND: Behaviourally HIV-infected adolescent females are at higher risk for abnormal cervical cytology and HPV infection compared to those who are uninfected, but data on perinatally HIV-infected adolescent females are lacking.

METHODS: Cervical cytology, HPV infection and E6/E7 mRNA were assessed in sexually active 12-24-year-old adolescent females: perinatally HIV-infected (group 1,

RESULTS: Median age was lower in group 1 (18 years) than in groups 2 (24 years) and 3 (20.5 years) (

CONCLUSIONS: Despite the younger age and shorter time since sexual debut, cervical cytological abnormalities and HPV infection were as common in perinatally HIV-infected as in behaviourally infected and uninfected adolescents. HPV vaccination, pre-cancer screening and antiretroviral treatment in HIV-infected female adolescents should be implemented to minimise the risk of cervical cancer.

Keywords: HPV; Pap smear; adolescents; cervix; perinatal HIV

References

  1. Vaccine. 2013 Aug 20;31(37):3962-71 - PubMed
  2. Clin Infect Dis. 2004 Mar 1;38(5):737-42 - PubMed
  3. Value Health. 2012 Jan-Feb;15(1 Suppl):S29-34 - PubMed
  4. Adv Clin Exp Med. 2012 Nov-Dec;21(6):759-66 - PubMed
  5. N Engl J Med. 2007 May 10;356(19):1928-43 - PubMed
  6. JAMA. 2007 Aug 15;298(7):743-53 - PubMed
  7. PLoS One. 2012;7(1):e30736 - PubMed
  8. AIDS Patient Care STDS. 2014 Feb;28(2):66-70 - PubMed
  9. J Infect Dis. 2004 Oct 15;190(8):1413-21 - PubMed
  10. BMC Infect Dis. 2013 Jan 30;13:53 - PubMed
  11. Cancer Causes Control. 2010 Mar;21(3):433-43 - PubMed
  12. Anal Quant Cytol Histol. 2011 Dec;33(6):311-5 - PubMed
  13. Obstet Gynecol. 2010 Aug;116(2 Pt 1):469-72 - PubMed
  14. J Acquir Immune Defic Syndr. 2013 Apr 1;62(4):405-13 - PubMed
  15. J Adolesc Health. 2001 Sep;29(3 Suppl):49-56 - PubMed
  16. Arch Pediatr Adolesc Med. 2000 Feb;154(2):127-34 - PubMed
  17. Arch Pathol Lab Med. 2012 Aug;136(8):956-60 - PubMed
  18. Eur J Cancer. 2013 Oct;49(15):3262-73 - PubMed
  19. Am J Clin Pathol. 2005 May;123(5):716-23 - PubMed
  20. Gynecol Oncol. 2012 Aug;126(2):207-10 - PubMed
  21. Ann Intern Med. 2008 May 20;148(10):728-36 - PubMed
  22. Int J STD AIDS. 2008 Aug;19(8):529-32 - PubMed
  23. MMWR Morb Mortal Wkly Rep. 2010 May 28;59(20):626-9 - PubMed
  24. J Infect Dis. 2013 Aug 1;208(3):385-93 - PubMed
  25. PLoS Med. 2008 Jun 17;5(6):e132 - PubMed
  26. J Acquir Immune Defic Syndr. 2012 Nov 1;61(3):390-9 - PubMed
  27. Sex Transm Infect. 2013 Aug;89(5):392-4 - PubMed
  28. Vaccine. 2012 Nov 20;30 Suppl 5:F168-74 - PubMed
  29. Jpn J Infect Dis. 2011;64(5):411-6 - PubMed
  30. PLoS One. 2012;7(4):e35983 - PubMed
  31. Am J Public Health. 2007 Jun;97(6):1047-52 - PubMed
  32. MMWR Recomm Rep. 2007 Mar 23;56(RR-2):1-24 - PubMed

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