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Heidari K, Vafaee A, Rastekenari AM, et al. S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury: Systematic review and meta-analysis. Brain Inj. 2015;29(10):1146-1157doi: 10.3109/02699052.2015.1037349.
Heidari, K., Vafaee, A., Rastekenari, A. M., Taghizadeh, M., Shad, E. G., Eley, R., Sinnott, M., & Asadollahi, S. (2015). S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury: Systematic review and meta-analysis. Brain injury, 29(10), 1146-1157. https://doi.org/10.3109/02699052.2015.1037349
Heidari, Kamran, et al. "S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury: Systematic review and meta-analysis." Brain injury vol. 29,10 (2015): 1146-1157. doi: https://doi.org/10.3109/02699052.2015.1037349
Heidari K, Vafaee A, Rastekenari AM, Taghizadeh M, Shad EG, Eley R, Sinnott M, Asadollahi S. S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury: Systematic review and meta-analysis. Brain Inj. 2015 Sep;29(10):1146-1157. doi: 10.3109/02699052.2015.1037349. Epub 2015 Jun 11. PMID: 26067622.
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Brain Inj. 2015 Sep;29(10):1146-1157. doi: 10.3109/02699052.2015.1037349. Epub 2015 Jun 11.

S100B protein as a screening tool for computed tomography findings after mild traumatic brain injury: Systematic review and meta-analysis.

Brain injury

Kamran Heidari, Ali Vafaee, Alireza Maleki Rastekenari, Mehrdad Taghizadeh, Ensieh Ghaffari Shad, Rob Eley, Michael Sinnott, Shadi Asadollahi

Affiliations

  1. a Department of Emergency Medicine , Loghmane-Hakim Hospital, Shahid Beheshti University of Medical Sciences , Tehran , Iran.
  2. b School of Medicine, Babol University of Medical Sciences , Babol , Mazandaran , Iran.
  3. c School of Medicine, Alborz University of Medical Sciences , Karaj , Tehran , Iran.
  4. d Department of Emergency Medicine , Princess Alexandra Hospital , Queensland , Australia.
  5. e School of Medicine, The University of Queensland , Brisbane , Australia , and.
  6. f School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

PMID: 26067622 DOI: 10.3109/02699052.2015.1037349

Abstract

PRIMARY OBJECTIVE: To determine whether S100B protein in serum can predict intracranial lesions on computed tomography (CT) scan after mild traumatic brain injury (MTBI).

RESEARCH DESIGN: Systematic review and meta-analysis Methods and procedures: A literature search was conducted using Medline, Embase, Cochrane, Google Scholar, CINAHL, SUMSearch, Bandolier, Trip databases, bibliographies from identified articles and review article references. Eligible articles were defined as observational studies including patients with MTBI who underwent post-traumatic head CT scan and assessing the screening role of S100B protein.

MAIN OUTCOMES AND RESULTS: There was a significant positive association between S100B protein concentration and positive CT scan (22 studies, SMD = 1.92, 95% CI = 1.29-2.45, I

CONCLUSIONS: After MTBI, serum S100B protein levels are significantly associated with the presence of intracranial lesions on CT scan. Measuring the protein could be useful in screening high risk MTBI patients and decreasing unnecessary CT examinations.

Keywords: Brain injuries; S100 protein; computed tomography; diagnosis; meta-analysis; screening

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