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Engel GA, Wilbur AK, Westmark A, et al. Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques. Emerg Microbes Infect. 2012;1(10):e30doi: 10.1038/emi.2012.31.
Engel, G. A., Wilbur, A. K., Westmark, A., Horn, D., Johnson, J., & Jones-Engel, L. (2012). Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques. Emerging microbes & infections, 1(10), e30. https://doi.org/10.1038/emi.2012.31
Engel, Gregory A, et al. "Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques." Emerging microbes & infections vol. 1,10 (2012): e30. doi: https://doi.org/10.1038/emi.2012.31
Engel GA, Wilbur AK, Westmark A, Horn D, Johnson J, Jones-Engel L. Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques. Emerg Microbes Infect. 2012 Oct;1(10):e30. doi: 10.1038/emi.2012.31. Epub 2012 Oct 10. PMID: 26038402; PMCID: PMC3636427.
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Emerg Microbes Infect. 2012 Oct;1(10):e30. doi: 10.1038/emi.2012.31. Epub 2012 Oct 10.

Naturally acquired Mycobacterium tuberculosis complex in laboratory pig-tailed macaques.

Emerging microbes & infections

Gregory A Engel, Alicia K Wilbur, Andrew Westmark, Dara Horn, Jordan Johnson, Lisa Jones-Engel

Affiliations

  1. Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA ; Swedish/Cherry Hill Family Medicine , Seattle 98122, WA, USA.
  2. Evolutionary Emergence of Infectious Diseases Laboratory, National Primate Research Center, University of Washington , Seattle 98125, WA, USA.

PMID: 26038402 PMCID: PMC3636427 DOI: 10.1038/emi.2012.31

Abstract

Here we present a case series from a primate research facility. The index case, a 4-year-old pig-tailed macaque (Macaca nemestrina) experimentally infected with chimeric simian-human immunodeficiency virus (SHIVSF162 P4), developed weight loss and was euthanized. Based on necropsy results the animal was diagnosed with opportunistic atypical mycobacteriosis associated with simian AIDS (SAIDS). Subsequently, tissues from the index animal, as well as tissues and oral mucosal swabs from six SHIV-infected contacts, were analyzed using molecular methods and found to contain nucleic acid sequences characteristic of Mycobacterium tuberculosis complex (MTBC). These data suggest that existing protocols fail to reliably detect MTBC infection in laboratory primates used as experimental models.

Keywords: atypical mycobacteriosis; coinfection; IS6110; Macaca; MTBC; pig-tailed macaque; SHIVSF162 P4

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