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Woo PC, Lau SK, Li KS, et al. Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5. Emerg Microbes Infect. 2012;1(11):e35doi: 10.1038/emi.2012.45.
Woo, P. C., Lau, S. K., Li, K. S., Tsang, A. K., & Yuen, K. Y. (2012). Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5. Emerging microbes & infections, 1(11), e35. https://doi.org/10.1038/emi.2012.45
Woo, Patrick Cy, et al. "Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5." Emerging microbes & infections vol. 1,11 (2012): e35. doi: https://doi.org/10.1038/emi.2012.45
Woo PC, Lau SK, Li KS, Tsang AK, Yuen KY. Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5. Emerg Microbes Infect. 2012 Nov;1(11):e35. doi: 10.1038/emi.2012.45. Epub 2012 Nov 07. PMID: 26038405; PMCID: PMC3630921.
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Emerg Microbes Infect. 2012 Nov;1(11):e35. doi: 10.1038/emi.2012.45. Epub 2012 Nov 07.

Genetic relatedness of the novel human group C betacoronavirus to Tylonycteris bat coronavirus HKU4 and Pipistrellus bat coronavirus HKU5.

Emerging microbes & infections

Patrick Cy Woo, Susanna Kp Lau, Kenneth Sm Li, Alan Kl Tsang, Kwok-Yung Yuen

Affiliations

  1. Department of Microbiology, The University of Hong Kong , Hong Kong, China ; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong , Hong Kong, China ; Research Centre of Infection and Immunology, The University of Hong Kong , Hong Kong, China ; Carol Yu Centre for Infection, The University of Hong Kong , Hong Kong, China.
  2. Department of Microbiology, The University of Hong Kong , Hong Kong, China.

PMID: 26038405 PMCID: PMC3630921 DOI: 10.1038/emi.2012.45

Abstract

The recent outbreak of severe respiratory infections associated with a novel group C betacoronavirus (HCoV-EMC) from Saudi Arabia has drawn global attention to another highly probable "SARS-like" animal-to-human interspecies jumping event in coronavirus (CoV). The genome of HCoV-EMC is most closely related to Tylonycteris bat coronavirus HKU4 (Ty-BatCoV HKU4) and Pipistrellus bat coronavirus HKU5 (Pi-BatCoV HKU5) we discovered in 2006. Phylogenetically, HCoV-EMC is clustered with Ty-BatCoV HKU4/Pi-BatCoV HKU5 with high bootstrap supports, indicating that HCoV-EMC is a group C betaCoV. The major difference between HCoV-EMC and Ty-BatCoV HKU4/Pi-BatCoV HKU5 is in the region between S and E, where HCoV-EMC possesses five ORFs (NS3a-NS3e) instead of four, with low (31%-62%) amino acid identities to Ty-BatCoV HKU4/Pi-BatCoV HKU5. Comparison of the seven conserved replicase domains for species demarcation shows that HCoV-EMC is a novel CoV species. More intensive surveillance studies in bats and other animals may reveal the natural host of HCoV-EMC.

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