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Manayi A, Vazirian M, Saeidnia S. Echinacea purpurea: Pharmacology, phytochemistry and analysis methods. Pharmacogn Rev. 2015;9(17):63-72doi: 10.4103/0973-7847.156353.
Manayi, A., Vazirian, M., & Saeidnia, S. (2015). Echinacea purpurea: Pharmacology, phytochemistry and analysis methods. Pharmacognosy reviews, 9(17), 63-72. https://doi.org/10.4103/0973-7847.156353
Manayi, Azadeh, et al. "Echinacea purpurea: Pharmacology, phytochemistry and analysis methods." Pharmacognosy reviews vol. 9,17 (2015): 63-72. doi: https://doi.org/10.4103/0973-7847.156353
Manayi A, Vazirian M, Saeidnia S. Echinacea purpurea: Pharmacology, phytochemistry and analysis methods. Pharmacogn Rev. 2015 Jan-Jun;9(17):63-72. doi: 10.4103/0973-7847.156353. PMID: 26009695; PMCID: PMC4441164.
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Pharmacogn Rev. 2015 Jan-Jun;9(17):63-72. doi: 10.4103/0973-7847.156353.

Echinacea purpurea: Pharmacology, phytochemistry and analysis methods.

Pharmacognosy reviews

Azadeh Manayi, Mahdi Vazirian, Soodabeh Saeidnia

Affiliations

  1. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  2. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
  3. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran ; Division of Pharmacy, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, India.

PMID: 26009695 PMCID: PMC4441164 DOI: 10.4103/0973-7847.156353

Abstract

Echinacea purpurea (Asteraceae) is a perennial medicinal herb with important immunostimulatory and anti-inflammatory properties, especially the alleviation of cold symptoms. The plant also attracted scientists' attention to assess other aspects of its beneficial effects. For instance, antianxiety, antidepression, cytotoxicity, and antimutagenicity as induced by the plant have been revealed in various studies. The findings of the clinical trials are controversial in terms of side effects. While some studies revealed the beneficial effects of the plant on the patients and no severe adverse effects, some others have reported serious side effects including abdominal pain, angioedema, dyspnea, nausea, pruritus, rash, erythema, and urticaria. Other biological activities of the plant such as antioxidant, antibacterial, antiviral, and larvicidal activities have been reported in previous experimental studies. Different classes of secondary metabolites of the plant such as alkamides, caffeic acid derivatives, polysaccharides, and glycoproteins are believed to be biologically and pharmacologically active. Actually, concurrent determination and single analysis of cichoric acid and alkamides have been successfully developed mainly by using high-performance liquid chromatography (HPLC) coupled with different detectors including UV spectrophotometric, coulometric electrochemical, and electrospray ionization mass spectrometric detectors. The results of the studies which were controversial revealed that in spite of major experiments successfully accomplished using E. purpurea, many questions remain unanswered and future investigations may aim for complete recognition of the plant's mechanism of action using new, complementary methods.

Keywords: Analysis methods; Echinacea purpurea; anti-inflammatory; clinical trial; cytotoxic; immunomodulatory; psychotic

References

  1. Carbohydr Res. 2000 Aug 7;327(4):497-504 - PubMed
  2. Planta Med. 1984 Oct;50(5):366-75 - PubMed
  3. Phytother Res. 2010 Nov;24(11):1605-13 - PubMed
  4. Phytomedicine. 2003 Jan;10(1):66-86 - PubMed
  5. J Biol Chem. 2003 Oct 3;278(40):38105-8 - PubMed
  6. Food Chem Toxicol. 2010 May;48(5):1170-7 - PubMed
  7. Fitoterapia. 2008 Jan;79(1):53-8 - PubMed
  8. Antimicrob Agents Chemother. 1998 Jan;42(1):140-6 - PubMed
  9. Antiviral Res. 1998 Aug;39(2):101-11 - PubMed
  10. Vaccine. 2010 May 21;28(23):3956-62 - PubMed
  11. Am J Med. 1999 Feb;106(2):138-43 - PubMed
  12. J Ethnopharmacol. 2007 Mar 1;110(1):148-53 - PubMed
  13. Phytomedicine. 2008 Aug;15(8):547-54 - PubMed
  14. Phytomedicine. 2002 Jul;9(5):390-7 - PubMed
  15. Food Chem Toxicol. 2009 Jun;47(6):1304-10 - PubMed
  16. Planta Med. 2007 Jun;73(7):615-23 - PubMed
  17. Genomics. 2006 Dec;88(6):801-8 - PubMed
  18. Talanta. 2005 Jun 15;66(5):1094-7 - PubMed
  19. Phytomedicine. 2010 Jul;17(8-9):563-8 - PubMed
  20. Planta Med. 2000 Apr;66(3):241-4 - PubMed
  21. Clin Infect Dis. 2005 Mar 15;40(6):807-10 - PubMed
  22. J Pharm Pharmacol. 2002 Oct;54(10):1379-83 - PubMed
  23. Daru. 2011;19(3):173-86 - PubMed
  24. Planta Med. 2002 Sep;68(9):780-3 - PubMed
  25. J Pharm Pharmacol. 2005 Aug;57(8):929-54 - PubMed
  26. Planta Med. 1978 Feb;33(1):89-102 - PubMed
  27. Fertil Steril. 1999 Mar;71(3):517-22 - PubMed
  28. Daru. 2013 Jul 25;21(1):61 - PubMed
  29. J Ethnopharmacol. 2012 Oct 11;143(3):914-9 - PubMed
  30. Arzneimittelforschung. 1991 Oct;41(10):1076-81 - PubMed
  31. J Natl Cancer Inst. 1989 May 3;81(9):669-75 - PubMed
  32. Int J Immunopharmacol. 1997 Jul;19(7):371-9 - PubMed
  33. Int J Immunopharmacol. 1993 Jul;15(5):605-14 - PubMed
  34. J Chromatogr A. 2003 Jan 31;986(1):73-81 - PubMed
  35. Planta Med. 1994 Feb;60(1):37-40 - PubMed
  36. J AOAC Int. 2011 Sep-Oct;94(5):1400-10 - PubMed
  37. Int Immunopharmacol. 2002 Feb;2(2-3):381-7 - PubMed
  38. Phytomedicine. 1999 Mar;6(1):1-6 - PubMed
  39. Oncogene. 1999 Nov 22;18(49):6853-66 - PubMed
  40. Virol J. 2009 Nov 13;6:197 - PubMed
  41. Phytochemistry. 2011 Oct;72(14-15):1848-53 - PubMed
  42. Phytomedicine. 2002 Apr;9(3):249-53 - PubMed
  43. Exp Gerontol. 2000 Aug;35(5):627-39 - PubMed
  44. J Chromatogr A. 2002 Feb 1;945(1-2):239-47 - PubMed
  45. Cell. 1996 Oct 4;87(1):13-20 - PubMed
  46. Cell Mol Immunol. 2004 Oct;1(5):343-50 - PubMed
  47. Res Vet Sci. 2011 Aug;91(1):82-5 - PubMed
  48. Clin Pharmacol Ther. 2004 Jan;75(1):89-100 - PubMed
  49. Phytomedicine. 2006 Nov;13(9-10):688-94 - PubMed
  50. Int J Immunopharmacol. 1991;13(1):27-37 - PubMed
  51. Planta Med. 2001 Dec;67(9):863-4 - PubMed
  52. J Agric Food Chem. 2000 May;48(5):1466-72 - PubMed
  53. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 1;902:151-6 - PubMed
  54. Phytomedicine. 2005 Sep;12(9):644-7 - PubMed
  55. FEBS Lett. 2004 Nov 19;577(3):563-9 - PubMed
  56. J Biol Chem. 2006 May 19;281(20):14192-206 - PubMed
  57. Nat Immun. 1993 Mar-Apr;12(2):66-78 - PubMed
  58. Antiviral Res. 1998 Jul;39(1):55-61 - PubMed
  59. Phytomedicine. 2005 Sep;12(9):625-31 - PubMed
  60. Planta Med. 2008 May;74(6):633-7 - PubMed
  61. Int Immunopharmacol. 2009 Jul;9(7-8):850-8 - PubMed
  62. J Pharm Biomed Anal. 2009 Jul 12;49(5):1141-9 - PubMed
  63. Pharmacol Rev. 2006 Sep;58(3):389-462 - PubMed
  64. Planta Med. 2005 Aug;71(8):701-5 - PubMed
  65. J Assist Reprod Genet. 1999 Feb;16(2):87-91 - PubMed
  66. Phytomedicine. 2000 Jul;7(4):273-82 - PubMed
  67. Planta Med. 2002 Jun;68(6):572-4 - PubMed
  68. J Chromatogr A. 2006 Jan 27;1103(2):219-28 - PubMed
  69. Drug Discov Today. 2006 Aug;11(15-16):725-32 - PubMed
  70. J Clin Pharm Ther. 2004 Feb;29(1):7-13 - PubMed

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