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Nunes AR, Alves MG, Moreira PI, et al. Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?. Curr Neuropharmacol. 2014;12(6):475-89doi: 10.2174/1570159X13666141204220539.
Nunes, A. R., Alves, M. G., Moreira, P. I., Oliveira, P. F., & Silva, B. M. (2014). Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?. Current neuropharmacology, 12(6), 475-89. https://doi.org/10.2174/1570159X13666141204220539
Nunes, Ana R, et al. "Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?." Current neuropharmacology vol. 12,6 (2014): 475-89. doi: https://doi.org/10.2174/1570159X13666141204220539
Nunes AR, Alves MG, Moreira PI, Oliveira PF, Silva BM. Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?. Curr Neuropharmacol. 2014 Dec;12(6):475-89. doi: 10.2174/1570159X13666141204220539. PMID: 25977676; PMCID: PMC4428023.
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Curr Neuropharmacol. 2014 Dec;12(6):475-89. doi: 10.2174/1570159X13666141204220539.

Can Tea Consumption be a Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration?.

Current neuropharmacology

Ana R Nunes, Marco G Alves, Paula I Moreira, Pedro F Oliveira, Branca M Silva

Affiliations

  1. CICS - UBI - Health Sciences Research Centre, University of Beira Interior, 6201-506 Covilhã, Portugal;
  2. CNC - Center for Neuroscience and Cell Biology, University of Coimbra and Laboratory of Physiology, Faculty of Medicine, University of Coimbra, 3004-517 Coimbra, Portugal.

PMID: 25977676 PMCID: PMC4428023 DOI: 10.2174/1570159X13666141204220539

Abstract

Diabetes mellitus (DM) is a metabolic disease that is rapidly increasing and has become a major public health problem. Type 2 DM (T2DM) is the most common type, accounting for up to 90-95% of the new diagnosed DM cases. The brain is very susceptible to glucose fluctuations and hyperglycemia-induced oxidative stress (OS). It is well known that DM and the risk of developing neurodegenerative diseases are associated. Tea, Camellia sinensis L., is one of the most consumed beverages. It contains several phytochemicals, such as polyphenols, methylxanthines (mainly caffeine) and L-theanine that are often reported to be responsible for tea's health benefits, including in brain. Tea phytochemicals have been reported to be responsible for tea's significant antidiabetic and neuroprotective properties and antioxidant potential. Epidemiological studies have shown that regular consumption of tea has positive effects on DM-caused complications and protects the brain against oxidative damage, contributing to an improvement of the cognitive function. Among the several reported benefits of tea consumption, those related with neurodegenerative diseases are of great interest. Herein, we discuss the potential beneficial effects of tea consumption and tea phytochemicals on DM and how their action can counteract the severe brain damage induced by this disease.

Keywords: Brain; L-theanine; caffeine; catechins; diabetes mellitus; tea

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