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Irvine J, Cross N, Lynn K, et al. IgA nephropathy in identical twins: an excellent donor and recipient outcome 11 years after transplantation. Clin Kidney J. 2012;5(3):232-3doi: 10.1093/ckj/sfs022.
Irvine, J., Cross, N., Lynn, K., Robson, R., Searle, M., Morton, J., Armstrong, S., & Roake, J. (2012). IgA nephropathy in identical twins: an excellent donor and recipient outcome 11 years after transplantation. Clinical kidney journal, 5(3), 232-3. https://doi.org/10.1093/ckj/sfs022
Irvine, John, et al. "IgA nephropathy in identical twins: an excellent donor and recipient outcome 11 years after transplantation." Clinical kidney journal vol. 5,3 (2012): 232-3. doi: https://doi.org/10.1093/ckj/sfs022
Irvine J, Cross N, Lynn K, Robson R, Searle M, Morton J, Armstrong S, Roake J. IgA nephropathy in identical twins: an excellent donor and recipient outcome 11 years after transplantation. Clin Kidney J. 2012 Jun;5(3):232-3. doi: 10.1093/ckj/sfs022. Epub 2012 Mar 26. PMID: 26069772; PMCID: PMC4400500.
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Clin Kidney J. 2012 Jun;5(3):232-3. doi: 10.1093/ckj/sfs022. Epub 2012 Mar 26.

IgA nephropathy in identical twins: an excellent donor and recipient outcome 11 years after transplantation.

Clinical kidney journal

John Irvine, Nicholas Cross, Kelvin Lynn, Richard Robson, Martin Searle, John Morton, Sarah Armstrong, Justin Roake

Affiliations

  1. Department of Nephrology, Christchurch Hospital, Christchurch, New Zealand.
  2. Department of Vascular, Endovascular and Transplant Surgery, Christchurch Hospital, Christchurch, New Zealand.

PMID: 26069772 PMCID: PMC4400500 DOI: 10.1093/ckj/sfs022

Abstract

We present a case of IgA nephropathy (IgAN) in monozygotic twins with excellent donor and recipient outcome 11 years after transplantation. The recipient developed IgAN at 26 years and progressed to end-stage renal failure 10 years later. His identical twin who had hypertension, intermittent microscopic haematuria and positive IgA immunofluorescence on biopsy became his donor. Eleven years following transplant, in the absence of immunosuppression, the recipient has stable graft function [estimated glomerular filtration rate (eGFR) 47 mL/min/1.73 m(2), Modification of Diet in Renal Disease (MDRD)], controlled hypertension on two medications and minor microscopic haematuria. The donor has good renal function (eGFR 51 mL/min/1.73 m(2), MDRD), controlled hypertension on one medication and normal urine.

Keywords: IgA nephropathy; background; kidney; monozygotic twin; transplantation

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