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Kerschbaum J, Mayer G, Maurer A. High-dose antioxidant therapy and steroids might improve the outcome of acute renal failure from intoxication by Cortinarius rubellus: report of two cases. Clin Kidney J. 2012;5(6):576-8doi: 10.1093/ckj/sfs129.
Kerschbaum, J., Mayer, G., & Maurer, A. (2012). High-dose antioxidant therapy and steroids might improve the outcome of acute renal failure from intoxication by Cortinarius rubellus: report of two cases. Clinical kidney journal, 5(6), 576-8. https://doi.org/10.1093/ckj/sfs129
Kerschbaum, Julia, et al. "High-dose antioxidant therapy and steroids might improve the outcome of acute renal failure from intoxication by Cortinarius rubellus: report of two cases." Clinical kidney journal vol. 5,6 (2012): 576-8. doi: https://doi.org/10.1093/ckj/sfs129
Kerschbaum J, Mayer G, Maurer A. High-dose antioxidant therapy and steroids might improve the outcome of acute renal failure from intoxication by Cortinarius rubellus: report of two cases. Clin Kidney J. 2012 Dec;5(6):576-8. doi: 10.1093/ckj/sfs129. Epub 2012 Oct 26. PMID: 26069805; PMCID: PMC4400554.
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Clin Kidney J. 2012 Dec;5(6):576-8. doi: 10.1093/ckj/sfs129. Epub 2012 Oct 26.

High-dose antioxidant therapy and steroids might improve the outcome of acute renal failure from intoxication by Cortinarius rubellus: report of two cases.

Clinical kidney journal

Julia Kerschbaum, Gert Mayer, Anton Maurer

Affiliations

  1. Department of Internal Medicine IV (Nephrology and Hypertension) , Medical University Innsbruck , Innsbruck , Austria.

PMID: 26069805 PMCID: PMC4400554 DOI: 10.1093/ckj/sfs129

Abstract

Only a small number of cases with favourable outcome after acute renal failure due to intoxication by Cortinarius sp. have been reported in the literature, and approximately half of the patients develop chronic renal failure and dialysis-dependency. We report the case of a couple with acute renal failure after accidental intake of Cortinarius rubellus and a favourable outcome after treatment with high-dose antioxidant therapy with N-acetylcysteine and steroids. Dialysis was never necessary in both patients and renal function was almost normal at the end of follow-up. Underdiagnosis of this rare cause of acute renal failure is likely due to the fact that affected patients develop symptoms of intoxication after a delay of 2-30 days. In patients with unclear acute renal failure with or without gastrointestinal symptoms, intoxication from Cortinarius sp. should be considered as a differential diagnosis. Early treatment with high-dose antioxidant therapy and steroids might be effective in reducing the risk of chronic renal failure.

Keywords: Cortinarius rubellus; acute renal failure; intoxication; therapy

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