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Yáñez-Mó M, Siljander PR, Andreu Z, et al. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015;4:27066doi: 10.3402/jev.v4.27066.
Yáñez-Mó, M., Siljander, P. R., Andreu, Z., Zavec, A. B., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., Colás, E., Cordeiro-da Silva, A., Fais, S., Falcon-Perez, J. M., Ghobrial, I. M., Giebel, B., Gimona, M., Graner, M., Gursel, I., Gursel, M., Heegaard, N. H., Hendrix, A., Kierulf, P., Kokubun, K., Kosanovic, M., Kralj-Iglic, V., Krämer-Albers, E. M., Laitinen, S., Lässer, C., Lener, T., Ligeti, E., Linē, A., Lipps, G., Llorente, A., Lötvall, J., Manček-Keber, M., Marcilla, A., Mittelbrunn, M., Nazarenko, I., Nolte-'t Hoen, E. N., Nyman, T. A., O'Driscoll, L., Olivan, M., Oliveira, C., Pállinger, �. �., Del Portillo, H. A., Reventós, J., Rigau, M., Rohde, E., Sammar, M., Sánchez-Madrid, F., Santarém, N., Schallmoser, K., Ostenfeld, M. S., Stoorvogel, W., Stukelj, R., Van der Grein, S. G., Vasconcelos, M. H., Wauben, M. H., & De Wever, O. (2015). Biological properties of extracellular vesicles and their physiological functions. Journal of extracellular vesicles, 427066. https://doi.org/10.3402/jev.v4.27066
Yáñez-Mó, María, et al. "Biological properties of extracellular vesicles and their physiological functions." Journal of extracellular vesicles vol. 4 (2015): 27066. doi: https://doi.org/10.3402/jev.v4.27066
Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Linē A, Lipps G, Llorente A, Lötvall J, Manček-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015 May 14;4:27066. doi: 10.3402/jev.v4.27066. eCollection 2015. PMID: 25979354; PMCID: PMC4433489.
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J Extracell Vesicles. 2015 May 14;4:27066. doi: 10.3402/jev.v4.27066. eCollection 2015.

Biological properties of extracellular vesicles and their physiological functions.

Journal of extracellular vesicles

María Yáñez-Mó, Pia R-M Siljander, Zoraida Andreu, Apolonija Bedina Zavec, Francesc E Borràs, Edit I Buzas, Krisztina Buzas, Enriqueta Casal, Francesco Cappello, Joana Carvalho, Eva Colás, Anabela Cordeiro-da Silva, Stefano Fais, Juan M Falcon-Perez, Irene M Ghobrial, Bernd Giebel, Mario Gimona, Michael Graner, Ihsan Gursel, Mayda Gursel, Niels H H Heegaard, An Hendrix, Peter Kierulf, Katsutoshi Kokubun, Maja Kosanovic, Veronika Kralj-Iglic, Eva-Maria Krämer-Albers, Saara Laitinen, Cecilia Lässer, Thomas Lener, Erzsébet Ligeti, Aija Linē, Georg Lipps, Alicia Llorente, Jan Lötvall, Mateja Manček-Keber, Antonio Marcilla, Maria Mittelbrunn, Irina Nazarenko, Esther N M Nolte-'t Hoen, Tuula A Nyman, Lorraine O'Driscoll, Mireia Olivan, Carla Oliveira, Éva Pállinger, Hernando A Del Portillo, Jaume Reventós, Marina Rigau, Eva Rohde, Marei Sammar, Francisco Sánchez-Madrid, N Santarém, Katharina Schallmoser, Marie Stampe Ostenfeld, Willem Stoorvogel, Roman Stukelj, Susanne G Van der Grein, M Helena Vasconcelos, Marca H M Wauben, Olivier De Wever

Affiliations

  1. Unidad de Investigación, Hospital Sta Cristina, Instituto de Investigaciones Sanitarias Princesa (IIS-IP), Madrid, Spain.
  2. Departamento de Biología Molecular, UAM, Madrid, Spain; [email protected]; [email protected].
  3. Extracellular Vesicle Research, Division of Biochemistry and Biotechnology, Department of Biosciences, University of Helsinki, Helsinki, Finland.
  4. Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; [email protected].
  5. Departamento de Biología Molecular, UAM, Madrid, Spain.
  6. Laboratory for Molecular Biology and Nanobiotechnology, National Institute of Chemistry, Ljubljana, Slovenia.
  7. IVECAT Group - "Germans Trias i Pujol" Research Institute, Badalona, Spain.
  8. Nephrology Service - "Germans Trias i Pujol" University Hospital, Badalona, Spain.
  9. Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary.
  10. Biological Research Centre, Hungarian Academy of Sciences, Szeged, Hungary.
  11. Faculty of Dentistry, University of Szeged, Szeged, Hungary.
  12. Metabolomics Unit, CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Spain.
  13. Department of Experimental Biomedicine and Clinical Neuroscience, Human Anatomy Section, University of Palermo, Palermo, Italy.
  14. Euro-Mediterranean Institute of Science and Technology, Palermo, Italy.
  15. Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
  16. Expression Regulation in Cancer, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.
  17. Research Unit in Biomedicine and Translational Oncology, Vall Hebron Institute of Research and Autonomous University of Barcelona, Barcelona, Spain.
  18. IBMC - Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal.
  19. Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal.
  20. Anti-Tumour Drugs Section, Department of Therapeutic Research and Medicines Evaluation, National Institute of Health (ISS), Rome, Italy.
  21. IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
  22. Dana-Farber Cancer Institute, Boston, MA, USA.
  23. Institute for Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
  24. Spinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria.
  25. Department of Blood Group Serology and Transfusion Medicine, Universitätsklinikum, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria.
  26. Department of Neurosurgery, University of Colorado Denver, CO, USA.
  27. Department of Molecular Biology and Genetics, Thorlab-Therapeutic Oligonucleotide Research Lab, Bilkent University, Ankara, Turkey.
  28. Department of Biological Sciences, Middle East Technical University, Ankara, Turkey.
  29. Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
  30. Analytical Protein Chemistry, Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark.
  31. Laboratory of Experimental Cancer Research, Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Ghent, Belgium.
  32. Bood Cell Research Group, Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway.
  33. Department of Immunochemistry and Glycobiology, Institute for the Application of Nuclear Energy, INEP, University of Belgrade, Belgrade, Serbia.
  34. Laboratory of Clinical Biophysics, Faculty of Health Sciences, University of Ljubljana, Ljubljana, Slovenia.
  35. Molecular Cell Biology and Focus Program Translational Neurosciences, University of Mainz, Mainz, Germany.
  36. Research and Cell Services, Finnish Red Cross Blood Service, Helsinki, Finland.
  37. Krefting Research Centre, Institute of Medicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  38. Department of Physiology, Semmelweis University, Budapest, Hungary.
  39. Latvian Biomedical Research and Study Centre, Riga, Latvia.
  40. Institute of Chemistry and Bioanalytics, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Switzerland.
  41. Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital - The Norwegian Radium Hospital, Oslo, Norway.
  42. National Institute of Chemistry, Laboratory of Biotechnology, Ljubljana, Slovenia.
  43. EN?FIST Centre of Excellence, Ljubljana, Slovenia.
  44. Departamento de Biología Celular y Parasitologia, Facultat de Farmacia, Universitat de Valencia, Valencia, Spain.
  45. Department of Vascular Biology and Inflammation, Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain.
  46. Institute for Environmental Health Sciences and Hospital Infection ControlMedical Center - University of Freiburg, Freiburg im Breisgau, Germany.
  47. Department of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
  48. Institute of Biotechnology, (Viikinkaari 1), University of Helsinki, Helsinki, Finland.
  49. School of Pharmacy and Pharmaceutical Sciences & Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
  50. Department of Pathology and Oncology, Faculty of Medicine, University of Porto, Porto, Portugal.
  51. ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona, Barcelona, Spain.
  52. Institució Catalana de Recerca I Estudis Avançats, Barcelona, Spain.
  53. Departament de Ciències Bàsiques, Universitat Internacional de Catalunya, and Institut de Recerca Biomèdica de Bellvitge, Barcelona, Spain.
  54. Department of Biotechnology Engineering, ORT Braude College, Karmiel, Israel.
  55. Servicio de Inmunología, Hospital de la Princesa, Instituto de Investigaciones Sanitarias Princesa (IIS-IP), Madrid, Spain.
  56. Departmnet of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
  57. Cancer Drug Resistance Group, Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.
  58. Department of Biological Sciences, Faculty of Pharmacy, University of Porto (FFUP), Porto, Portugal.

PMID: 25979354 PMCID: PMC4433489 DOI: 10.3402/jev.v4.27066

Abstract

In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.

Keywords: eukaryote; exosome; extracellular vesicle; microparticle; microvesicle; physiology; prokaryote

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