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Newmyer R, Mendelson J, Pang D, et al. Targeted Temperature Management in Pediatric Central Nervous System Disease. Curr Treat Options Pediatr. 2015;1(1):38-47doi: 10.1007/s40746-014-0008-y.
Newmyer, R., Mendelson, J., Pang, D., & Fink, E. L. (2015). Targeted Temperature Management in Pediatric Central Nervous System Disease. Current treatment options in pediatrics, 1(1), 38-47. https://doi.org/10.1007/s40746-014-0008-y
Newmyer, Robert, et al. "Targeted Temperature Management in Pediatric Central Nervous System Disease." Current treatment options in pediatrics vol. 1,1 (2015): 38-47. doi: https://doi.org/10.1007/s40746-014-0008-y
Newmyer R, Mendelson J, Pang D, Fink EL. Targeted Temperature Management in Pediatric Central Nervous System Disease. Curr Treat Options Pediatr. 2015 Mar 01;1(1):38-47. doi: 10.1007/s40746-014-0008-y. PMID: 26042193; PMCID: PMC4450147.
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Curr Treat Options Pediatr. 2015 Mar 01;1(1):38-47. doi: 10.1007/s40746-014-0008-y.

Targeted Temperature Management in Pediatric Central Nervous System Disease.

Current treatment options in pediatrics

Robert Newmyer, Jenny Mendelson, Diana Pang, Ericka L Fink

Affiliations

  1. Children's Hospital of Pittsburgh of UPMC (Pittsburgh, PA USA).

PMID: 26042193 PMCID: PMC4450147 DOI: 10.1007/s40746-014-0008-y

Abstract

Acute central nervous system conditions due to hypoxic-ischemic encephalopathy, traumatic brain injury (TBI), status epilepticus, and central nervous system infection/inflammation, are a leading cause of death and disability in childhood. There is a critical need for effective neuroprotective therapies to improve outcome targeting distinct disease pathology. Fever, defined as patient temperature > 38°C, has been clearly shown to exacerbate brain injury. Therapeutic hypothermia (HT) is an intervention using targeted temperature management that has multiple mechanisms of action and robust evidence of efficacy in multiple experimental models of brain injury. Prospective clinical evidence for its neuroprotective efficacy exists in narrowly-defined populations with hypoxic-ischemic injury outside of the pediatric age range while trials comparing hypothermia to normothermia after TBI have failed to demonstrate a benefit on outcome but consistently demonstrate potential use in decreasing refractory intracranial pressure. Data in children from prospective, randomized controlled trials using different strategies of targeted temperature management for various outcomes are few but a large study examining HT versus controlled normothermia to improve neurological outcome in cardiac arrest is underway.

Keywords: brain disease; hypothermia; neurocritical care; pediatric; targeted temperature management

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