Display options
Cite
Krzyżanowska M, Muszer K, Chabowski K, et al. Assessment of the sensory threshold in patients with atopic dermatitis and psoriasis. Postepy Dermatol Alergol. 2015;32(2):94-100doi: 10.5114/pdia.2014.44013.
Krzyżanowska, M., Muszer, K., Chabowski, K., & Reich, A. (2015). Assessment of the sensory threshold in patients with atopic dermatitis and psoriasis. Postepy dermatologii i alergologii, 32(2), 94-100. https://doi.org/10.5114/pdia.2014.44013
Krzyżanowska, Magdalena, et al. "Assessment of the sensory threshold in patients with atopic dermatitis and psoriasis." Postepy dermatologii i alergologii vol. 32,2 (2015): 94-100. doi: https://doi.org/10.5114/pdia.2014.44013
Krzyżanowska M, Muszer K, Chabowski K, Reich A. Assessment of the sensory threshold in patients with atopic dermatitis and psoriasis. Postepy Dermatol Alergol. 2015 Apr;32(2):94-100. doi: 10.5114/pdia.2014.44013. Epub 2015 Mar 30. PMID: 26015778; PMCID: PMC4436235.
Copy Download .nbib Format: NLM
Share it on

Postepy Dermatol Alergol. 2015 Apr;32(2):94-100. doi: 10.5114/pdia.2014.44013. Epub 2015 Mar 30.

Assessment of the sensory threshold in patients with atopic dermatitis and psoriasis.

Postepy dermatologii i alergologii

Magdalena Krzyżanowska, Katarzyna Muszer, Konrad Chabowski, Adam Reich

Affiliations

  1. Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland. Head of the Department: Prof. Jacek C. Szepietowski MD, PhD.
  2. Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland. Head of the Department: Prof. Jacek C. Szepietowski MD, PhD ; Faculty of Microsystem Electronics and Photonics, Wroclaw University of Technology, Wroclaw, Poland. Head of the Department: Prof. Teodor Gotszalk.

PMID: 26015778 PMCID: PMC4436235 DOI: 10.5114/pdia.2014.44013

Abstract

INTRODUCTION: Atopic dermatitis (AD) and psoriasis are chronic inflammatory skin diseases frequently accompanied by itching. The exact pathogenesis of dermatological pruritus remains unknown, but it is believed that altered skin innervation may play a role.

AIM: The assessment of the sensory threshold in AD and psoriasis in relation to pruritus experienced by patients.

MATERIAL AND METHODS: A total of 18 subjects with AD, 20 with psoriasis and 49 healthy controls were exposed to alternating current generated by the current source. A selected preset of current frequencies (ranging from 5 Hz to 2000 Hz) allowed a selective stimulation of different nerve endings (Aβ, Aδ and C-type). Pruritus severity was measured with visual analogue scale (VAS) and an itch questionnaire developed in house. All results were analyzed statistically.

RESULTS: Sensory thresholds within the uninvolved skin of AD or psoriasis patients were significantly higher than in healthy volunteers (p < 0.001), and no significant differences were found between AD and psoriasis (p > 0.05). Similarly, sensory thresholds within the diseased skin of AD or psoriasis were significantly higher than in the normal skin (p < 0.01), and patients with psoriasis had also a significantly higher threshold than AD individuals (p < 0.05). The sensory threshold inversely correlated with pruritus severity in AD and psoriasis and the highest correlation was found for 5 Hz frequency predominantly stimulating C fibers (VAS: R = -0.32, p < 0.05; pruritus questionnaire: R = 0.54, p < 0.001).

CONCLUSIONS: Evaluation of the sensory threshold may be a valuable tool for pruritus assessment, but further studies are still warranted.

Keywords: diagnostics; itch; pruritus; skin diseases

References

  1. Br J Dermatol. 2010 Jan;162(1):83-90 - PubMed
  2. J Pharmacol Exp Ther. 2001 Apr;297(1):352-6 - PubMed
  3. Diabet Med. 1994 Nov;11(9):872-6 - PubMed
  4. Neurology. 2004 Jan 27;62(2):212-7 - PubMed
  5. Muscle Nerve. 1997 Nov;20(11):1468-9 - PubMed
  6. Postepy Dermatol Alergol. 2014 Oct;31(5):299-304 - PubMed
  7. Dermatology. 2003;206(3):204-11 - PubMed
  8. Pain. 2005 Jan;113(1-2):148-54 - PubMed
  9. Br J Dermatol. 2011 Aug;165(2):277-84 - PubMed
  10. Mol Pain. 2006 May 08;2:16 - PubMed
  11. J Dermatol Sci. 2012 Apr;66(1):37-43 - PubMed
  12. Br J Dermatol. 2003 Oct;149(4):718-30 - PubMed
  13. J Surg Res. 2004 May 15;118(2):154-60 - PubMed
  14. Acta Derm Venereol. 2010 May;90(3):257-63 - PubMed
  15. Exp Dermatol. 2002 Feb;11(1):12-24 - PubMed
  16. J Invest Dermatol. 1982 Dec;79(6):368-73 - PubMed
  17. Neurosci Lett. 1997 Jun 13;228(3):199-202 - PubMed
  18. Int J Dermatol. 2002 Apr;41(4):212-6 - PubMed
  19. Acta Derm Venereol. 2011 Oct;91(6):656-9 - PubMed
  20. Dermatology. 1993;186(1):23-31 - PubMed
  21. Acta Derm Venereol. 2013 Mar 27;93(2):214-5 - PubMed
  22. Dermatologica. 1978;157(4):238-44 - PubMed
  23. Mol Pain. 2005 Mar 25;1:13 - PubMed
  24. Acta Derm Venereol. 2012 Sep;92(5):497-501 - PubMed
  25. Lancet. 1998 May 9;351(9113):1436-7 - PubMed
  26. Virchows Arch. 1998 Apr;432(4):363-70 - PubMed
  27. Diabet Med. 1991;8 Spec No:S63-6 - PubMed

Publication Types