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Zhang P, Kornev AP, Wu J, et al. Discovery of Allostery in PKA Signaling. Biophys Rev. 2015;7(2):227-238doi: 10.1007/s12551-015-0170-x.
Zhang, P., Kornev, A. P., Wu, J., & Taylor, S. S. (2015). Discovery of Allostery in PKA Signaling. Biophysical reviews, 7(2), 227-238. https://doi.org/10.1007/s12551-015-0170-x
Zhang, Ping, et al. "Discovery of Allostery in PKA Signaling." Biophysical reviews vol. 7,2 (2015): 227-238. doi: https://doi.org/10.1007/s12551-015-0170-x
Zhang P, Kornev AP, Wu J, Taylor SS. Discovery of Allostery in PKA Signaling. Biophys Rev. 2015 Jun 01;7(2):227-238. doi: 10.1007/s12551-015-0170-x. PMID: 26097522; PMCID: PMC4469037.
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Biophys Rev. 2015 Jun 01;7(2):227-238. doi: 10.1007/s12551-015-0170-x.

Discovery of Allostery in PKA Signaling.

Biophysical reviews

Ping Zhang, Alexandr P Kornev, Jian Wu, Susan S Taylor

Affiliations

  1. Department of Pharmacology, University of California at San Diego, La Jolla, California 92093.
  2. Department of Pharmacology, University of California at San Diego, La Jolla, California 92093 ; Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093.

PMID: 26097522 PMCID: PMC4469037 DOI: 10.1007/s12551-015-0170-x

Abstract

cAMP-dependent protein kinase (PKA) was the second protein kinase to be discovered and the PKA catalytic (C) subunit serves as a prototype for the large protein kinase superfamily that contains over 500 gene products. The protein kinases regulate much of biology in eukaryotic cells and they are now also a major therapeutic target. Although PKA was discovered nearly 50 years ago and the subsequent discovery of the regulatory subunits that bind cAMP and release the catalytic activity from the holoenzyme followed quickly. Thus in PKA we see the convergence of two major signaling mechanisms - protein phosphorylation and second messenger signaling through cAMP. Crystallography provides a foundation for understanding function, and the structure of the isolated regulatory (R) and C-subunits have been extremely informative. Yet it is the R

Keywords: Allostery; Cyclic AMP (cAMP); PKA Regulatory (R) Subunit; PKA catalytic (C) subunit; cAMP-dependent protein kinase (PKA)

References

  1. Science. 2007 Oct 12;318(5848):274-9 - PubMed
  2. Brain. 2014 May;137(Pt 5):1361-73 - PubMed
  3. Nature. 1960 Feb 13;185(4711):416-22 - PubMed
  4. Proc Natl Acad Sci U S A. 1970 Sep;67(1):408-14 - PubMed
  5. J Biol Chem. 1968 Jul 10;243(13):3763-5 - PubMed
  6. Proc Natl Acad Sci U S A. 1971 Oct;68(10):2444-7 - PubMed
  7. Crit Rev Clin Lab Sci. 1999 Aug;36(4):275-328 - PubMed
  8. Elife. 2013 Nov 05;2:e01319 - PubMed
  9. Ann N Y Acad Sci. 2002 Jun;968:75-95 - PubMed
  10. Nat Rev Mol Cell Biol. 2012 Oct;13(10):646-58 - PubMed
  11. N Engl J Med. 2011 Jun 9;364(23):2218-26 - PubMed
  12. Cell. 2007 Sep 21;130(6):1032-43 - PubMed
  13. Hum Mutat. 2010 Apr;31(4):369-79 - PubMed
  14. Nat Rev Mol Cell Biol. 2004 Dec;5(12):959-70 - PubMed
  15. Structure. 2001 Jan 10;9(1):73-82 - PubMed
  16. PLoS Biol. 2007 Mar;5(3):e17 - PubMed
  17. Adv Enzyme Regul. 1975;13:173-85 - PubMed
  18. Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14231-6 - PubMed
  19. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8851-5 - PubMed
  20. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1272-7 - PubMed
  21. Cell. 1995 Dec 29;83(7):1211-22 - PubMed
  22. PLoS Comput Biol. 2008 Apr 11;4(4):e1000056 - PubMed
  23. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12443-8 - PubMed
  24. Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):45-50 - PubMed
  25. Science. 1991 Jul 26;253(5018):407-14 - PubMed
  26. J Biol Chem. 1959 Nov;234:2867-73 - PubMed
  27. J Biol Chem. 2014 Oct 24;289(43):30040-51 - PubMed
  28. J Biol Chem. 1980 Sep 10;255(17):8179-84 - PubMed
  29. J Biol Chem. 1975 Oct 10;250(19):7795-801 - PubMed
  30. Science. 2012 Feb 10;335(6069):712-6 - PubMed
  31. J Mol Biol. 2004 Apr 9;337(5):1183-94 - PubMed
  32. Science. 1995 Aug 11;269(5225):807-13 - PubMed
  33. Chem Biol. 2007 Sep;14(9):1031-42 - PubMed
  34. Nature. 1960 Feb 13;185(4711):422-7 - PubMed
  35. J Biol Chem. 2004 Feb 20;279(8):7029-36 - PubMed
  36. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2446-50 - PubMed
  37. Nature. 1996 Aug 15;382(6592):622-6 - PubMed
  38. Biochemistry. 2015 Jan 13;54(1):2-10 - PubMed
  39. J Biol Chem. 1958 Jun;232(2):1065-76 - PubMed
  40. Biochem Biophys Res Commun. 1970 May 11;39(3):335-43 - PubMed
  41. J Mol Biol. 2006 Mar 31;357(3):880-9 - PubMed
  42. Structure. 2010 Nov 10;18(11):1471-82 - PubMed
  43. Science. 2005 Feb 4;307(5710):690-6 - PubMed
  44. Curr Opin Neurobiol. 1997 Jun;7(3):397-403 - PubMed
  45. J Biol Chem. 2004 Apr 30;279(18):19084-90 - PubMed
  46. J Am Chem Soc. 2006 Jul 5;128(26):8406-7 - PubMed
  47. Protein Sci. 2009 Jul;18(7):1486-97 - PubMed
  48. Diabetes. 2001 Nov;50(11):2555-62 - PubMed
  49. Biochemistry. 1999 May 11;38(19):6352-60 - PubMed
  50. J Mol Biol. 1965 May;12:88-118 - PubMed

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