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Schlegel A, Kron P, Dutkowski P. Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application. Curr Transplant Rep. 2015;2(1):52-62doi: 10.1007/s40472-014-0046-1.
Schlegel, A., Kron, P., & Dutkowski, P. (2015). Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application. Current transplantation reports, 2(1), 52-62. https://doi.org/10.1007/s40472-014-0046-1
Schlegel, A, et al. "Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application." Current transplantation reports vol. 2,1 (2015): 52-62. doi: https://doi.org/10.1007/s40472-014-0046-1
Schlegel A, Kron P, Dutkowski P. Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application. Curr Transplant Rep. 2015;2(1):52-62. doi: 10.1007/s40472-014-0046-1. PMID: 26097802; PMCID: PMC4469295.
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Curr Transplant Rep. 2015;2(1):52-62. doi: 10.1007/s40472-014-0046-1.

Hypothermic Oxygenated Liver Perfusion: Basic Mechanisms and Clinical Application.

Current transplantation reports

A Schlegel, P Kron, P Dutkowski

Affiliations

  1. Department of Surgery and Transplantation, University Hospital Zürich, Raemistr. 100, 8091 Zurich, Switzerland.

PMID: 26097802 PMCID: PMC4469295 DOI: 10.1007/s40472-014-0046-1

Abstract

Dynamic preservation strategies such as hypothermic machine perfusion are increasingly discussed to improve liver graft quality before transplantation. This review summarizes current knowledge of this perfusion technique for liver preservation. We discuss optimization of perfusion conditions and current strategies to assess graft quality during cold perfusion. Next, we provide an overview of possible pathways of protection from ischemia-reperfusion injury. Finally, we report on recent clinical applications of human hypothermic machine liver perfusion.

Keywords: Hypothermic oxygenated perfusion; Ischemia-reperfusion injury; Mitochondria; ROS

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