Display options
Cite
Oehme D, Goldschlager T, Ghosh P, et al. Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials. Stem Cells Int. 2015;2015:946031doi: 10.1155/2015/946031.
Oehme, D., Goldschlager, T., Ghosh, P., Rosenfeld, J. V., & Jenkin, G. (2015). Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials. Stem cells international, 2015946031. https://doi.org/10.1155/2015/946031
Oehme, David, et al. "Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials." Stem cells international vol. 2015 (2015): 946031. doi: https://doi.org/10.1155/2015/946031
Oehme D, Goldschlager T, Ghosh P, Rosenfeld JV, Jenkin G. Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials. Stem Cells Int. 2015;2015:946031. doi: 10.1155/2015/946031. Epub 2015 May 14. PMID: 26074979; PMCID: PMC4446495.
Copy Download .nbib Format: NLM
Share it on

Stem Cells Int. 2015;2015:946031. doi: 10.1155/2015/946031. Epub 2015 May 14.

Cell-Based Therapies Used to Treat Lumbar Degenerative Disc Disease: A Systematic Review of Animal Studies and Human Clinical Trials.

Stem cells international

David Oehme, Tony Goldschlager, Peter Ghosh, Jeffrey V Rosenfeld, Graham Jenkin

Affiliations

  1. The Ritchie Centre, Monash Institute of Medical Research (MIMR-PHI), Monash University, Clayton Branch, P.O. Box 6178, South Yarra, VIC 3141, Australia.
  2. Departments of Surgery and The Ritchie Centre, Monash Institute of Medical Research (MIMR-PHI), Monash University, Clayton Branch, 27-31 Wright Street, Clayton, VIC 3168, Australia.
  3. Proteobioactives Research Laboratories, P.O. Box 35, Brookvale, NSW 2100, Australia ; Mesoblast Ltd, Melbourne, VIC 3000, Australia.
  4. Department of Surgery, Monash University, Clayton, VIC 3168, Australia ; Department of Neurosurgery, Alfred Hospital, Level 5, The Alfred Centre, Commercial Road, Prahran, Melbourne, VIC 3168, Australia.
  5. The Ritchie Centre, Monash Institute of Medical Research (MIMR-PHI), Monash University, Clayton Branch, 27-31 Wright Street, Clayton, VIC 3168, Australia.

PMID: 26074979 PMCID: PMC4446495 DOI: 10.1155/2015/946031

Abstract

Low back pain and degenerative disc disease are a significant cause of pain and disability worldwide. Advances in regenerative medicine and cell-based therapies, particularly the transplantation of mesenchymal stem cells and intervertebral disc chondrocytes, have led to the publication of numerous studies and clinical trials utilising these biological therapies to treat degenerative spinal conditions, often reporting favourable outcomes. Stem cell mediated disc regeneration may bridge the gap between the two current alternatives for patients with low back pain, often inadequate pain management at one end and invasive surgery at the other. Through cartilage formation and disc regeneration or via modification of pain pathways stem cells are well suited to enhance spinal surgery practice. This paper will systematically review the current status of basic science studies, preclinical and clinical trials utilising cell-based therapies to repair the degenerate intervertebral disc. The mechanism of action of transplanted cells, as well as the limitations of published studies, will be discussed.

References

  1. Lancet. 2012 Dec 15;380(9859):2163-96 - PubMed
  2. J Vasc Interv Radiol. 2012 Aug;23 (8):1084-1088.e6 - PubMed
  3. Arthritis Rheum. 2005 Aug;52(8):2521-9 - PubMed
  4. Spine (Phila Pa 1976). 2003 Dec 1;28(23 ):2609-20 - PubMed
  5. Mol Biol Cell. 2002 Dec;13(12):4279-95 - PubMed
  6. Haematologica. 2007 Dec;92(12):1707-8 - PubMed
  7. Cytotechnology. 2009 Jan;59(1):55-64 - PubMed
  8. Clin Orthop Relat Res. 2005 Jan;(430):219-26 - PubMed
  9. Spine (Phila Pa 1976). 2005 Nov 1;30(21):2379-87 - PubMed
  10. Biomaterials. 2006 Jan;27(3):335-45 - PubMed
  11. Spine J. 2010 Dec;10(12):1089-97 - PubMed
  12. Transplantation. 2003 Oct 27;76(8):1208-13 - PubMed
  13. J Orthop Res. 2000 Nov;18(6):988-97 - PubMed
  14. Spine (Phila Pa 1976). 2009 May 20;34(12 ):1301-6 - PubMed
  15. Transplantation. 2011 Oct 15;92(7):822-8 - PubMed
  16. J Orthop Res. 2010 Oct;28(10 ):1267-75 - PubMed
  17. Eur Spine J. 2008 Jan;17(1):2-19 - PubMed
  18. Spine (Phila Pa 1976). 2000 Feb 15;25(4):487-92 - PubMed
  19. Spine (Phila Pa 1976). 2003 Mar 15;28(6):548-53 - PubMed
  20. Acta Neurochir (Wien). 2010 Oct;152(10):1771-7 - PubMed
  21. Gerontology. 1977;23(2):99-109 - PubMed
  22. J Neurosurg Spine. 2011 Mar;14(3):322-9 - PubMed
  23. Stem Cells Dev. 2009 Nov;18(9):1253-62 - PubMed
  24. Cancer Res. 2007 Oct 1;67(19):9142-9 - PubMed
  25. Spine (Phila Pa 1976). 2006 May 15;31(11):1177-86 - PubMed
  26. Spine (Phila Pa 1976). 2007 Feb 1;32(3):328-33 - PubMed
  27. Curr Stem Cell Res Ther. 2010 Dec;5(4):345-55 - PubMed
  28. J Orthop Res. 2008 May;26(5):589-600 - PubMed
  29. Connect Tissue Res. 2008;49(1):15-21 - PubMed
  30. Vet Pathol. 1976;13(6):414-27 - PubMed
  31. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1185-92 - PubMed
  32. Eur Spine J. 2006 Aug;15 Suppl 3:S433-8 - PubMed
  33. Eur Spine J. 2010 Apr;19(4):601-12 - PubMed
  34. Spine (Phila Pa 1976). 1998 Apr 1;23(7):751-7 - PubMed
  35. Curr Stem Cell Res Ther. 2013 Sep;8(5):381-93 - PubMed
  36. Spine (Phila Pa 1976). 2009 Jan 15;34(2):141-8 - PubMed
  37. Mol Ther. 2009 Nov;17(11):1959-66 - PubMed
  38. J Mater Sci Mater Med. 2007 Feb;18(2):303-8 - PubMed
  39. Spine J. 2009 Jul;9(7):585-94 - PubMed
  40. J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:68-71 - PubMed
  41. Spine (Phila Pa 1976). 2011 Dec 15;36(26):2252-9 - PubMed
  42. J Anat. 1995 Feb;186 ( Pt 1):43-53 - PubMed
  43. Tissue Eng Part A. 2011 Dec;17(23-24):3045-55 - PubMed
  44. Lancet. 1999 Aug 14;354(9178):581-5 - PubMed
  45. J Neurosurg Spine. 2012 May;16(5):479-88 - PubMed
  46. Spine J. 2005 Nov-Dec;5(6 Suppl):267S-279S - PubMed
  47. Arthritis Res Ther. 2010;12(6):R206 - PubMed
  48. Biomol Eng. 2007 Feb;24(1):5-21 - PubMed
  49. Lancet. 2008 May 10;371(9624):1579-86 - PubMed
  50. Spine J. 2010 Jun;10(6):514-29 - PubMed
  51. Eur Spine J. 2007 Apr;16(4):447-68 - PubMed
  52. Stem Cells Dev. 2006 Feb;15(1):136-7 - PubMed
  53. J Neurosurg Spine. 2011 Feb;14(2):273-80 - PubMed
  54. J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:15-20 - PubMed
  55. Spine (Phila Pa 1976). 1998 Jul 15;23(14):1531-8; discussion 1539 - PubMed
  56. Biomaterials. 2003 Sep;24(20):3531-41 - PubMed
  57. Eur Spine J. 2006 Aug;15 Suppl 3:S397-405 - PubMed
  58. Stem Cells Dev. 2007 Dec;16(6):953-63 - PubMed
  59. Eur Spine J. 2008 Sep;17(9):1131-48 - PubMed
  60. J Orthop Sci. 1999;4(4):286-92 - PubMed
  61. J Neurosurg Spine. 2009 Mar;10(3):265-72 - PubMed
  62. Cell Mol Biol Lett. 2004;9(2):363-73 - PubMed
  63. J Tissue Eng Regen Med. 2012 May;6(5):348-55 - PubMed
  64. Clin Orthop Relat Res. 2001 Aug;(389):94-101 - PubMed
  65. Spine J. 2010 Sep;10(9):802-10 - PubMed
  66. J Bone Miner Res. 2003 Apr;18(4):696-704 - PubMed
  67. J Bone Joint Surg Br. 2010 May;92(5):726-36 - PubMed
  68. Spine (Phila Pa 1976). 2004 Dec 1;29(23 ):2751-6 - PubMed
  69. Ann Biomed Eng. 2004 Mar;32(3):430-4 - PubMed
  70. Spine (Phila Pa 1976). 1999 Apr 15;24(8):739-41 - PubMed
  71. Eur Spine J. 2008 Dec;17 Suppl 4:492-503 - PubMed
  72. Spine (Phila Pa 1976). 1997 Feb 15;22(4):427-34 - PubMed
  73. Arthritis Res Ther. 2010;12(1):R28 - PubMed
  74. Spine (Phila Pa 1976). 2003 May 1;28(9):864-9; discussion 870 - PubMed
  75. Spine (Phila Pa 1976). 2011 Dec 1;36(25):2180-9 - PubMed
  76. Neurosurg Rev. 2015 Jul;38(3):429-45 - PubMed
  77. Tissue Eng Part A. 2010 Jul;16(7):2381-9 - PubMed
  78. Spine (Phila Pa 1976). 2006 Jan 1;31(1):4-9 - PubMed
  79. Spine (Phila Pa 1976). 2010 May 15;35(11):E475-80 - PubMed
  80. Spine (Phila Pa 1976). 2002 Aug 1;27(15):1626-33 - PubMed
  81. Spine (Phila Pa 1976). 2009 Oct 1;34(21):2297-304 - PubMed
  82. J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:10-4 - PubMed
  83. Joint Bone Spine. 2001 Dec;68(6):537-42 - PubMed
  84. Spine J. 2008 Nov-Dec;8(6):888-96 - PubMed
  85. Spine (Phila Pa 1976). 2010 Mar 1;35(5):531-6 - PubMed
  86. Cell Res. 2005 May;15(5):401-5 - PubMed
  87. J Orthop Res. 2009 Mar;27(3):374-9 - PubMed

Publication Types