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Mahmud S, Akhter S, Rahman MA, et al. Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models. Evid Based Complement Alternat Med. 2015;2015:782742doi: 10.1155/2015/782742.
Mahmud, S., Akhter, S., Rahman, M. A., Aklima, J., Akhter, S., Merry, S. R., Jubair, S. M., Dash, R., & Emran, T. B. (2015). Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models. Evidence-based complementary and alternative medicine : eCAM, 2015782742. https://doi.org/10.1155/2015/782742
Mahmud, Sakib, et al. "Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 782742. doi: https://doi.org/10.1155/2015/782742
Mahmud S, Akhter S, Rahman MA, Aklima J, Akhter S, Merry SR, Jubair SM, Dash R, Emran TB. Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models. Evid Based Complement Alternat Med. 2015;2015:782742. doi: 10.1155/2015/782742. Epub 2015 May 17. PMID: 26075001; PMCID: PMC4449917.
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Evid Based Complement Alternat Med. 2015;2015:782742. doi: 10.1155/2015/782742. Epub 2015 May 17.

Antithrombotic Effects of Five Organic Extracts of Bangladeshi Plants In Vitro and Mechanisms in In Silico Models.

Evidence-based complementary and alternative medicine : eCAM

Sakib Mahmud, Samina Akhter, Md Atiar Rahman, Jannatul Aklima, Shaheen Akhter, Syeeda Rayhana Merry, S M Rakibul Jubair, Raju Dash, Talha Bin Emran

Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh.
  2. Bangladesh Forest Research Institute, Chittagong 4000, Bangladesh.
  3. Department of Pharmacy, BGC Trust University, Chittagong 4000, Bangladesh.

PMID: 26075001 PMCID: PMC4449917 DOI: 10.1155/2015/782742

Abstract

This research was carried out to investigate the thrombolytic effects of the methanolic extracts of five Bangladeshi plants. Phytochemical metabolites of those plants have been identified to elucidate whether the plant-derived metabolites are linked with the thrombolytic effects. Potential computer aided models were adopted in this study to find out a structure-function correlation between the phytochemical constituents and thrombolytic effects using the secondary metabolites as ligands and tissue plasminogen activator (t-PA) as receptor for the best fit ligand-receptor interaction.

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