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Biazzo A, De Paolis M, Righi A, et al. Osteosarcoma in identical twins: A case report. J Clin Orthop Trauma. 2014;5(4):257-60doi: 10.1016/j.jcot.2014.09.007.
Biazzo, A., De Paolis, M., Righi, A., Lana, D., & Donati, D. M. (2014). Osteosarcoma in identical twins: A case report. Journal of clinical orthopaedics and trauma, 5(4), 257-60. https://doi.org/10.1016/j.jcot.2014.09.007
Biazzo, Alessio, et al. "Osteosarcoma in identical twins: A case report." Journal of clinical orthopaedics and trauma vol. 5,4 (2014): 257-60. doi: https://doi.org/10.1016/j.jcot.2014.09.007
Biazzo A, De Paolis M, Righi A, Lana D, Donati DM. Osteosarcoma in identical twins: A case report. J Clin Orthop Trauma. 2014 Dec;5(4):257-60. doi: 10.1016/j.jcot.2014.09.007. Epub 2014 Oct 24. PMID: 25983508; PMCID: PMC4263994.
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J Clin Orthop Trauma. 2014 Dec;5(4):257-60. doi: 10.1016/j.jcot.2014.09.007. Epub 2014 Oct 24.

Osteosarcoma in identical twins: A case report.

Journal of clinical orthopaedics and trauma

Alessio Biazzo, Massimiliano De Paolis, Alberto Righi, Debora Lana, Davide Maria Donati

Affiliations

  1. Oncologic Department, Rizzoli Orthopaedic Institute, via Pupilli 1, Bologna 40136, Italy.
  2. Pathology Department, Rizzoli Orthopaedic Institute, via Di Barbiano 1, Bologna 40136, Italy.

PMID: 25983508 PMCID: PMC4263994 DOI: 10.1016/j.jcot.2014.09.007

Abstract

Osteosarcoma (OS) is the most frequent primary malignant bone tumor, if we exclude myeloma, a hematologic systemic disease. OS is relatively uncommon, with an estimated incidence of 600 cases per year in the United States. Among siblings is an even rarer phenomenon, with scattered reports throughout the English literature(1). We report the incidence of OS in identical twins. The first case is a low-grade OS arisen in the proximal tibia of a 25-year-old man, treated with en-bloc resection and reconstruction with allograft. The second one is a high-grade OS of the distal tibia of the 33-year-old twin, developed in a previous non-ossifying fibroma (NOF) followed over the time. The patient was treated with neo-adjuvant chemotherapy, en-bloc resection and reconstruction with allograft. Our literature review did not find any case of OS in identical twins, while 26 reports of OS in siblings are described.

Keywords: Familial osteosarcoma; Osteosarcoma; Twins

References

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